Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant

The broadly conserved bacterial signalling molecule cyclic-di-adenosine monophosphate (c-di-AMP) controls osmoresistance via its regulation of potassium (K+) and compatible solute uptake. High levels of c-di-AMP resulting from inactivation of c-di-AMP phosphodiesterase activity leads to poor growth...

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Veröffentlicht in:	PLoS genetics 2018-08, Vol.14 (8), p.e1007574-e1007574
Hauptverfasser:	Pham, Huong Thi, Nhiep, Nguyen Thi Hanh, Vu, Thu Ngoc Minh, Huynh, TuAnh Ngoc, Zhu, Yan, Huynh, Anh Le Diep, Chakrabortti, Alolika, Marcellin, Esteban, Lo, Raquel, Howard, Christopher B, Bansal, Nidhi, Woodward, Joshua J, Liang, Zhao-Xun, Turner, Mark S
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Adenosine Monophosphate AMP Bacteria Bacterial Proteins - genetics Bacterial Proteins - physiology Betaine - metabolism Bioengineering Biology and Life Sciences Cell division Cyclic AMP - metabolism E coli Enzymes Food Funding Gene Expression Regulation, Bacterial Glycine Glycine betaine Gram-positive bacteria Intracellular Lactococcus Lactococcus lactis - genetics Lactococcus lactis - physiology Medicine and Health Sciences Multidrug resistance Mutation Nanotechnology Operon Osmolar Concentration Osmolarity Osmoprotectants Osmoregulation Phosphodiesterase Physical Sciences Physiological aspects Potassium Potassium (Nutrient) Potassium - metabolism Proteins Research and Analysis Methods Second Messenger Systems Sensors Streptococcus infections Supervision Transcription Turgor Water stress
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