Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents

The development of novel therapeutics is urgently required for diseases where existing treatments are failing due to the emergence of resistance. This is particularly pertinent for parasitic infections of the tropics and sub-tropics, referred to collectively as neglected tropical diseases, where the...

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Veröffentlicht in:	PLoS computational biology 2018-10, Vol.14 (10), p.e1006515-e1006515
Hauptverfasser:	Giuliani, Sandra, Silva, Arthur C, Borba, Joyce V V B, Ramos, Pablo I P, Paveley, Ross A, Muratov, Eugene N, Andrade, Carolina Horta, Furnham, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Algorithms Animals Binding sites Bioinformatics Biological activity Biology and Life Sciences Cdc2 protein CHK1 protein Chronic infection Computational Biology - methods Computer applications Databases, Protein Disease Drug development Drug Repositioning - methods Drug resistance Drugs Evolution Flavopiridol Gene expression Genomes Hygiene Imatinib Incentives Inhibitors Kinases Laboratories Ligands Medical treatment Medicine and Health Sciences Methods Molecular biology Parasitic diseases Pathogens Pharmaceutical industry Praziquantel Protein kinase Protein Kinase Inhibitors - pharmacology Proteins R&D Reproducibility of Results Research & development Schistosoma Schistosoma - drug effects Schistosomiasis Schistosomicides - pharmacology Software Species Target recognition Tropical diseases Tropical environments
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