A novel nonosteocytic regulatory mechanism of bone modeling

Osteocytes, cells forming an elaborate network within the bones of most vertebrate taxa, are thought to be the master regulators of bone modeling, a process of coordinated, local bone-tissue deposition and removal that keeps bone strains at safe levels throughout life. Neoteleost fish, however, lack...

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Veröffentlicht in:	PLoS biology 2019-02, Vol.17 (2), p.e3000140
Hauptverfasser:	Ofer, Lior, Dean, Mason N, Zaslansky, Paul, Kult, Shiri, Shwartz, Yulia, Zaretsky, Janna, Griess-Fishheimer, Shelley, Monsonego-Ornan, Efrat, Zelzer, Elazar, Shahar, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biocompatibility Biology Biology and Life Sciences Biomechanical Phenomena Biomedical materials Bone and Bones - cytology Bone and Bones - metabolism Bone cells Bone remodeling Bone Remodeling - genetics Bones Chondrocytes - cytology Chondrocytes - metabolism Collagen Type I - genetics Collagen Type I - metabolism Deposition Environmental science Feedback, Physiological Fish Fish Proteins - genetics Fish Proteins - metabolism Fishes Food Gene expression Gene Expression Regulation Glycoproteins - genetics Glycoproteins - metabolism Humans Laboratories Loading Mammals Mechanical loading Mechanotransduction, Cellular - genetics Medicine and Health Sciences Modelling Nutrition Observations Oryzias - genetics Oryzias - metabolism Osteoblasts - cytology Osteoblasts - metabolism Osteocytes Osteogenesis - genetics Osteoporosis Physical Sciences Physiological aspects Protein Isoforms - genetics Protein Isoforms - metabolism Publishing Regulators Regulatory mechanisms (biology) Research and Analysis Methods SOST protein Species Specificity Swimming Swimming - physiology Tomography Vertebra Vertebrae Vertebrates Veterinary colleges Veterinary medicine Zebrafish Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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