More diversity in epithelial cell polarity: A fruit flies' gut feeling
Multicellular animals face the principle challenge to deal with two distinct compartments: the internal organismal compartment and the external environment. This challenge is met by the differentiation of cell sheets into epithelia, which provide a dynamic barrier in tissues, organs, and organisms....
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| Veröffentlicht in: | PLoS biology 2018-12, Vol.16 (12), p.e3000082 |
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| description | Multicellular animals face the principle challenge to deal with two distinct compartments: the internal organismal compartment and the external environment. This challenge is met by the differentiation of cell sheets into epithelia, which provide a dynamic barrier in tissues, organs, and organisms. Cell polarity is key to all functions of epithelia, and compromising polarity causes many severe diseases. Within the past 20 years, research on Drosophila melanogaster discovered a conserved molecular machinery that controls epithelial polarity. Recent findings suggest that the textbook Drosophila-based paradigm of the control of epithelial polarity may not be as universal as previously assumed. |
| doi_str_mv | 10.1371/journal.pbio.3000082 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Public Library of Science (PLoS) |
| subjects | Animals Biology and Life Sciences Cell growth Cell Polarity Cysts Diptera Drosophila Drosophila melanogaster Drosophila Proteins Epithelial Cells Fruit flies Insects Kinases Mammals Medicine and Health Sciences Molecular machines Morphogenesis Organs Physiological aspects Polarity Primer Proteins Regulation Research and Analysis Methods |
| title | More diversity in epithelial cell polarity: A fruit flies' gut feeling |
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