Candida albicans biofilm-induced vesicles confer drug resistance through matrix biogenesis

Cells from all kingdoms of life produce extracellular vesicles (EVs). Their cargo is protected from the environment by the surrounding lipid bilayer. EVs from many organisms have been shown to function in cell-cell communication, relaying signals that impact metazoan development, microbial quorum se...

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Veröffentlicht in:	PLoS biology 2018-10, Vol.16 (10), p.e2006872-e2006872
Hauptverfasser:	Zarnowski, Robert, Sanchez, Hiram, Covelli, Antonio S, Dominguez, Eddie, Jaromin, Anna, Bernhardt, Jörg, Mitchell, Kaitlin F, Heiss, Christian, Azadi, Parastoo, Mitchell, Aaron, Andes, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial agents BASIC BIOLOGICAL SCIENCES biochemistry & molecular biology Biofilms Biofilms - drug effects Biofilms - growth & development Biology and Life Sciences Biosynthesis Candida albicans Candida albicans - drug effects Candida albicans - pathogenicity Candida albicans - physiology Cell interactions Chemical communication Communities Cryoelectron Microscopy Diabetes Drug resistance Drug Resistance, Fungal Endosomal Sorting Complexes Required for Transport - genetics Endosomal Sorting Complexes Required for Transport - physiology Eukaryotes Evolution Extracellular matrix Extracellular Polymeric Substance Matrix - drug effects Extracellular Polymeric Substance Matrix - physiology Extracellular Polymeric Substance Matrix - ultrastructure Extracellular Vesicles - drug effects Extracellular Vesicles - physiology Extracellular Vesicles - ultrastructure Flow cytometry Fluconazole Fourier transforms Fungal Proteins - metabolism Fungicides Gene expression Humans Hypersensitivity Immunology Infectious diseases life sciences & biomedicine Lipid bilayers Lipid Metabolism Lipids Mass spectrometry Medical equipment Medicine Medicine and Health Sciences Microbial Interactions - drug effects Microbial Interactions - physiology Microorganisms Microscopy, Electron, Scanning Models, Biological Mutants Mutation Planktonic cells Polysaccharides Proteins Proteome - metabolism Quorum sensing Relaying Research and Analysis Methods Scientific imaging Short Reports Vesicles
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