EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development

Extensive apoptosis is often seen in patterning mutants, suggesting that tissues can detect and eliminate potentially harmful mis-specified cells. Here, we show that the pattern of apoptosis in the embryonic epidermis of Drosophila is not a response to fate mis-specification but can instead be expla...

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Veröffentlicht in:	PLoS biology 2018-10, Vol.16 (10), p.e3000027-e3000027
Hauptverfasser:	Crossman, Samuel H, Streichan, Sebastian J, Vincent, Jean-Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Apoptosis Apoptosis - genetics Apoptosis - physiology Biology and Life Sciences Body Patterning - genetics Body Patterning - physiology Cell death Cell survival Cell Survival - genetics Cell Survival - physiology Crick, Francis Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Embryos Epidermal growth factor Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Epidermal growth factor receptors Epidermis Epidermis - embryology Epidermis - metabolism ErbB Receptors - genetics ErbB Receptors - metabolism Female Gene expression Genes Genes, Insect Growth factors Insects Ligands Male Medicine and Health Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mutants Mutation Neuregulin Neuregulins - genetics Neuregulins - metabolism Neuropeptides - genetics Neuropeptides - metabolism Pattern formation Patterning Receptors, Invertebrate Peptide - genetics Receptors, Invertebrate Peptide - metabolism Research and Analysis Methods Segmentation Short Reports Signal Transduction Signaling Survival Transforming growth factor
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