Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

The urinary metabolites "prostaglandin E2 metabolite" (PGE-M) and (Z)-7-[1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid (8-iso-PGF2α) are biomarkers of inflammation and oxidative damage, respectively, and are elevated in cigarette smokers. Relatively...

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Veröffentlicht in:	PloS one 2019-06, Vol.14 (6), p.e0218386-e0218386
Hauptverfasser:	McElroy, Joseph P, Carmella, Steven G, Heskin, Alisa K, Tang, Mei Kuen, Murphy, Sharon E, Reisinger, Sarah A, Jensen, Joni A, Hatsukami, Dorothy K, Hecht, Stephen S, Shields, Peter G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological markers Biology and Life Sciences Biomarkers Cancer Cardiovascular disease Chromatography Cigarette smoking Cigarette Smoking - adverse effects Cigarettes Cotinine Creatinine Damage Drug addiction Eicosanoids - metabolism Family medical history Female Health aspects Humans Inflammation Inflammation - etiology Inflammation - metabolism Inflammation Mediators - chemistry Inflammation Mediators - metabolism Liquid chromatography Male Mass spectrometry Mass spectroscopy Medical research Medicine and Health Sciences Mental disorders Mental health Metabolites Middle Aged Nicotine Oxidative Stress Prostaglandin E2 Prostaglandins Prostaglandins E - metabolism Risk factors Smoke Smokers Smoking Smoking Cessation Social Sciences Spectroscopy Tobacco Urine Varenicline
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