The contralateral kidney presents with impaired mitochondrial functions and disrupted redox homeostasis after 14 days of unilateral ureteral obstruction in mice

In unilateral ureteral obstruction (UUO), both oxidative stress and mitochondrial dysfunction are related to cell death. The aim of this study has been to characterize profiles of enzyme antioxidant activities and mitochondrial functioning of the contralateral (CL) compared to UUO and Sham (false-op...

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Veröffentlicht in:	PloS one 2019-06, Vol.14 (6), p.e0218986-e0218986
Hauptverfasser:	Bianco, Mario, Lopes, Jarlene A, Beiral, Hellen J V, Filho, João D D, Frankenfeld, Stephan P, Fortunato, Rodrigo S, Gattass, Cerli R, Vieyra, Adalberto, Takiya, Christina M
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Adenosine diphosphate Analysis Animals Antioxidants Antioxidants (Nutrients) Apoptosis Biochemistry Biology and Life Sciences Biophysics Brain Calcium Calcium ions Calcium Signaling Care and treatment Catalase Catalase - metabolism Cell death Cytochrome Cytochrome c Cytochrome oxidase Cytochrome-c oxidase Cytochromes Cytosol Diabetes Disease Models, Animal EDTA Electron transfer Electron transport chain Enzymes Glutathione Glutathione peroxidase Glutathione Peroxidase - metabolism Health aspects Heme Heme oxygenase (decyclizing) Homeostasis Kidney - cytology Kidney - metabolism Kidney - surgery Kidneys Kinases Laboratory rats Malate Male Medical research Medicine and Health Sciences Membrane potential Mice Mitochondria Mitochondria - metabolism Oxidases Oxidation-Reduction Oxidative stress Oxygen Oxygen consumption Oxygenase Pathogenesis Peroxidase Phosphorylation Physiology Proteins Pyruvic acid Reactive oxygen species Reactive Oxygen Species - metabolism Research and Analysis Methods Respiration Substrates Surgery Transcription factors Up-Regulation Ureteral obstruction Ureteral Obstruction - etiology Ureteral Obstruction - metabolism Ureteral Obstruction - surgery
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