Tumor M2-PK: A novel urine marker of bladder cancer

Bladder cancer is a "Warburg-like" tumor characterized by a reliance on aerobic glycolysis and expression of pyruvate kinase M2 (PKM2). PKM2 oscillates between an active tetramer and an inactive dimer. We aim to further characterize PKM2, in particular PKM2 dimer, as a urinary biomarker of...

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Veröffentlicht in:	PloS one 2019-06, Vol.14 (6), p.e0218737-e0218737
Hauptverfasser:	Liu, Weiya, Woolbright, Benjamin L, Pirani, Karim, Didde, Ryan, Abbott, Erika, Kaushik, Gaurav, Martin, Paige, Hamilton-Reeves, Jill, Taylor, 3rd, John A, Holzbeierlein, Jeffrey M, Anant, Shrikant, Lee, Eugene K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological markers Biology and Life Sciences Biomarkers Biomarkers, Tumor - chemistry Biomarkers, Tumor - urine Bladder Bladder cancer Cancer Cancer cells Care and treatment Carrier Proteins - chemistry Carrier Proteins - urine Case-Control Studies Caspase Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemotherapy Dimers Disease Drug therapy Drugs, Chinese Herbal - pharmacology EDTA Enzymes Ethylenediaminetetraacetic acids Female Gene expression Genetic aspects Glucose Glucose - metabolism Glycolysis Humans Isoforms Kinases Levels Male Medical research Medicine and Health Sciences Membrane Proteins - chemistry Membrane Proteins - urine Middle Aged Naphthoquinones - pharmacology Physical Sciences Physiology Protein Structure, Quaternary Proteins Pyruvate kinase Pyruvate Kinase - chemistry Pyruvate Kinase - urine Pyruvic acid Shikonin Statistical analysis Statistical methods Thyroid Hormone-Binding Proteins Thyroid Hormones - chemistry Thyroid Hormones - urine Tumor cell lines Tumors Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - urine Urine Urology
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