Somatic mosaic truncating mutations of PPM1D in blood can result from expansion of a mutant clone under selective pressure of chemotherapy

PPM1D (Protein phosphatase magnesium-dependent 1δ) is known as a damage response regulator, a part of the p53 negative feedback loop. Truncating mutations of PPM1D, resulting in overexpression, are frequently found in the blood of patients with breast or ovarian cancer. To identify whether the PPM1D...

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Veröffentlicht in:	PloS one 2019-06, Vol.14 (6), p.e0217521-e0217521
Hauptverfasser:	Kim, Borahm, Won, Dongju, Lee, Seung-Tae, Choi, Jong Rak
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biology and Life Sciences Blood Blood pressure Breast cancer Breast Neoplasms, Male - blood Breast Neoplasms, Male - drug therapy Breast Neoplasms, Male - genetics Cancer Cancer therapies Cancer treatment Care and treatment Cell cycle Chemotherapy Cisplatin Cisplatin - administration & dosage Cloning Deoxyribonucleic acid DNA DNA damage DNA repair Feedback loops Female Gene mutation Genetic testing Genetics Genomics Humans Laboratories Magnesium Male Medical research Medical tests Medicine Medicine and Health Sciences Middle Aged Mosaicism Mutation Negative feedback Neoplasm Proteins - blood Neoplasm Proteins - genetics Neoplastic Syndromes, Hereditary - blood Neoplastic Syndromes, Hereditary - drug therapy Neoplastic Syndromes, Hereditary - genetics Next-generation sequencing Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - blood Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics p53 Protein Phosphatase Phosphatases Protein phosphatase Protein Phosphatase 2C - blood Protein Phosphatase 2C - genetics Tumor proteins Tumors
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