Isolation, culturing and gene expression profiling of inner mass cells from stable and vulnerable carotid atherosclerotic plaques

The connective tissue components that form the atherosclerotic plaque body are produced by the plaque inner mass cells (PIMC), located inside the plaque. We report an approach to isolate and culture cells from the connective tissue of stable and vulnerable human atherosclerotic plaques based on elim...

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Veröffentlicht in:	PloS one 2019-06, Vol.14 (6), p.e0218892-e0218892
Hauptverfasser:	Novikova, Olga A, Nazarkina, Zhanna K, Cherepanova, Anna V, Laktionov, Petr P, Chelobanov, Boris P, Murashov, Ivan S, Deev, Roman V, Pokushalov, Evgeny A, Karpenko, Andrey A, Laktionov, Pavel P
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Aged Aggrecan Angiogenesis Antigens, CD - metabolism Arteriosclerosis Atherogenesis Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerotic plaque B cells Biology Biology and Life Sciences Biomarkers - metabolism Biotechnology Calcification Carotid Arteries - metabolism CD105 antigen CD14 antigen CD34 antigen Cell adhesion & migration Cell culture Cell Proliferation - genetics Connective tissues Criminal investigation Culture media Endothelial growth factors Extracellular matrix Female Fibronectin Fibronectins Gene expression Gene Expression Profiling - methods Genetic aspects Growth factors Humans Laboratories Lysis Macrophages Macrophages - metabolism Male Markers Medical research Medicine Medicine and Health Sciences Morphology Muscles Myocytes, Smooth Muscle - metabolism Neovascularization Patients Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - metabolism Plaques Proteins Research and Analysis Methods Ribonucleic acid RNA Smooth muscle Stimulants T cells Tissues Transcriptome - genetics Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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