Hyaluronic acid and chondroitin sulfate, alone or in combination, efficiently counteract induced bladder cell damage and inflammation

Interstitial cystitis and/or bladder pain syndrome (IC/BPS) are characterized by discomfort, abdominal pain, and pelvic pain, and they are often associated with chronic diseases. Pathological conditions related to IC/BPS can occur due to a defect in the integrity of the bladder lining. This defect h...

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Veröffentlicht in:	PloS one 2019-06, Vol.14 (6), p.e0218475-e0218475
Hauptverfasser:	Stellavato, Antonietta, Pirozzi, Anna Virginia Adriana, Diana, Paola, Reale, Sabrina, Vassallo, Valentina, Fusco, Alessandra, Donnarumma, Giovanna, De Rosa, Mario, Schiraldi, Chiara
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Anti-inflammatory agents Antibacterial agents Biological markers Biology and Life Sciences Biomarkers Biotechnology Bladder Calcium Cattle Cell Line Chondroitin Chondroitin sulfate Chondroitin Sulfates - therapeutic use Chronic diseases Chronic illnesses Complications and side effects Cystitis Cytokines Damage assessment Enzyme-linked immunosorbent assay Epithelium Extracellular matrix Fermentation Gene Expression Regulation Glycosaminoglycans Glycosaminoglycans - metabolism Histology Humans Hyaluronic acid Hyaluronic Acid - therapeutic use Hydrodynamics Inflammation Inflammation - drug therapy Integrity Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Interleukin-8 - genetics Interleukin-8 - metabolism Interleukins Interstitial cystitis Medical devices Medical electronics Medical equipment Medical research Medicine Medicine and Health Sciences Models, Biological Molecular biology Mucopolysaccharides NF-kappa B - metabolism NF-κB protein Pain Pelvic pain Peptides Permeability Physical Sciences Polymerase chain reaction Proteoglycans Research and Analysis Methods Signal Transduction Sulfates Three dimensional models Transcription Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Urinary Bladder - pathology Urothelium Western blotting Zonula Occludens-1 Protein - metabolism
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