Anopheles gambiae TEP1 forms a complex with the coiled-coil domain of LRIM1/APL1C following a conformational change in the thioester domain

The complement-like protein thioester-containing protein 1 (TEP1) is a key factor in the immune response of the malaria vector Anopheles gambiae to pathogens. Multiple allelic variants of TEP1 have been identified in laboratory strains and in the field, and are correlated with distinct immunophenoty...

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Veröffentlicht in:	PloS one 2019-06, Vol.14 (6), p.e0218203-e0218203
Hauptverfasser:	Williams, Marni, Contet, Alicia, Hou, Chun-Feng David, Levashina, Elena A, Baxter, Richard H G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Animals Anopheles Anopheles - metabolism Anopheles gambiae Biochemistry Biology Biology and Life Sciences Biophysics Bonds (Securities) Disulfide bonds Disulfides - metabolism Domains Esters - metabolism Hydrolysis Immune response Immune system Infections Insect Proteins - chemistry Insect Proteins - metabolism Laboratories Leucine Malaria Medical research Medicine and Health Sciences Molecular structure Mosquitoes Parasites Pathogenic microorganisms Physical Sciences Precipitates Proteases Protein Binding Protein Domains Protein Stability Proteins Stability analysis Sulfhydryl Compounds - metabolism Temperature Variation Vector-borne diseases
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