Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves
Pneumonia is one of the most economically important respiratory diseases of calves and knowledge of the impact of clinical disease on pharmacokinetics (PK) in young calves is limited. This study was undertaken to investigate the efficacy and PK of two antibiotics, tulathromycin and danofloxacin, in...
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| description | Pneumonia is one of the most economically important respiratory diseases of calves and knowledge of the impact of clinical disease on pharmacokinetics (PK) in young calves is limited. This study was undertaken to investigate the efficacy and PK of two antibiotics, tulathromycin and danofloxacin, in two age groups of calves experimentally infected with Pasteurella multocida. Both danofloxacin, a fluoroquinolone antibiotic, and tulathromycin, a macrolide antibiotic is approved for the treatment of bovine respiratory disease (BRD). To evaluate potential influences of age and disease on drug distribution and elimination in calves, plasma, interstitial fluid (ISF), and pulmonary epithelial lining fluid (PELF) were analyzed for drug concentrations. Concentrations for both drugs in the PELF were estimated by a urea dilution assay of the collected bronchoalveolar lavage fluids. Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters. For calves administered danofloxacin, the area under the curve (AUC) in the plasma was lower in 6-month old calves (18.9 ± 12.6 hr* μg/mL) vs. 3-week old calves (32.0 ± 8.2 hr* μg/mL). Clearance (CL/F) of danofloxacin was higher in 6-month old calves. In contrast, tulathromycin plasma concentrations were higher in 6 month old calves and CL/F was higher in 3-week old calves. Age did not significantly influence the ISF concentrations of danofloxacin or tulathromycin in calves with respiratory disease, unlike previous studies which reported higher ISF concentrations of danofloxacin and tulathromycin in 6-month old calves when compared to younger calves. PELF concentrations were higher than plasma and ISF for both danofloxacin and tulathromycin, but did not differ between age groups. Potential reasons for age-related differences on plasma concentration-time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored. |
| doi_str_mv | 10.1371/journal.pone.0218864 |
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This study was undertaken to investigate the efficacy and PK of two antibiotics, tulathromycin and danofloxacin, in two age groups of calves experimentally infected with Pasteurella multocida. Both danofloxacin, a fluoroquinolone antibiotic, and tulathromycin, a macrolide antibiotic is approved for the treatment of bovine respiratory disease (BRD). To evaluate potential influences of age and disease on drug distribution and elimination in calves, plasma, interstitial fluid (ISF), and pulmonary epithelial lining fluid (PELF) were analyzed for drug concentrations. Concentrations for both drugs in the PELF were estimated by a urea dilution assay of the collected bronchoalveolar lavage fluids. Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters. For calves administered danofloxacin, the area under the curve (AUC) in the plasma was lower in 6-month old calves (18.9 ± 12.6 hr* μg/mL) vs. 3-week old calves (32.0 ± 8.2 hr* μg/mL). Clearance (CL/F) of danofloxacin was higher in 6-month old calves. In contrast, tulathromycin plasma concentrations were higher in 6 month old calves and CL/F was higher in 3-week old calves. Age did not significantly influence the ISF concentrations of danofloxacin or tulathromycin in calves with respiratory disease, unlike previous studies which reported higher ISF concentrations of danofloxacin and tulathromycin in 6-month old calves when compared to younger calves. PELF concentrations were higher than plasma and ISF for both danofloxacin and tulathromycin, but did not differ between age groups. Potential reasons for age-related differences on plasma concentration-time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0218864</identifier><identifier>PMID: 31233558</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Age Factors ; Alveoli ; Analysis ; Animals ; Antibacterial agents ; Antibiotics ; Area Under Curve ; Bacteria ; Bacterial infections ; Beef cattle ; Biology and Life Sciences ; Bronchoalveolar Lavage Fluid - chemistry ; Bronchus ; Calves ; Cattle ; Cattle Diseases - drug therapy ; Chronology ; Dilution ; Disaccharides - administration & dosage ; Disaccharides - pharmacokinetics ; Disease ; Disease control ; Drug dosages ; Enzymes ; Extracellular Fluid - chemistry ; Female ; Fluoroquinolones - administration & dosage ; Fluoroquinolones - pharmacokinetics ; Gram-negative bacteria ; Heterocyclic Compounds - administration & dosage ; Heterocyclic Compounds - pharmacokinetics ; Impact analysis ; Infections ; Lung diseases ; Lungs ; Medical research ; Medical treatment ; Medicine and Health Sciences ; Metabolism ; Pasteurella Infections - drug therapy ; Pasteurella Infections - veterinary ; Pasteurella multocida - pathogenicity ; Pharmacokinetics ; Pharmacology ; Plasma ; Pneumonia ; Population ; Prevalence studies (Epidemiology) ; Respiration Disorders - drug therapy ; Respiration Disorders - veterinary ; Respiratory diseases ; Urea ; Veterinary colleges ; Veterinary medicine</subject><ispartof>PloS one, 2019-06, Vol.14 (6), p.e0218864</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3f5e0e46d8d534ecadddaa80333b9a15043e5a5b0914b84354e564dc24538ad43</citedby><cites>FETCH-LOGICAL-c692t-3f5e0e46d8d534ecadddaa80333b9a15043e5a5b0914b84354e564dc24538ad43</cites><orcidid>0000-0001-5700-8810 ; 0000-0002-9834-2089</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590872/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590872/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31233558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gladue, Douglas</contributor><creatorcontrib>Mzyk, Danielle A</creatorcontrib><creatorcontrib>Bublitz, Claire M</creatorcontrib><creatorcontrib>Martinez, Marilyn N</creatorcontrib><creatorcontrib>Davis, Jennifer L</creatorcontrib><creatorcontrib>Baynes, Ronald E</creatorcontrib><creatorcontrib>Smith, Geof W</creatorcontrib><title>Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Pneumonia is one of the most economically important respiratory diseases of calves and knowledge of the impact of clinical disease on pharmacokinetics (PK) in young calves is limited. This study was undertaken to investigate the efficacy and PK of two antibiotics, tulathromycin and danofloxacin, in two age groups of calves experimentally infected with Pasteurella multocida. Both danofloxacin, a fluoroquinolone antibiotic, and tulathromycin, a macrolide antibiotic is approved for the treatment of bovine respiratory disease (BRD). To evaluate potential influences of age and disease on drug distribution and elimination in calves, plasma, interstitial fluid (ISF), and pulmonary epithelial lining fluid (PELF) were analyzed for drug concentrations. Concentrations for both drugs in the PELF were estimated by a urea dilution assay of the collected bronchoalveolar lavage fluids. Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters. For calves administered danofloxacin, the area under the curve (AUC) in the plasma was lower in 6-month old calves (18.9 ± 12.6 hr* μg/mL) vs. 3-week old calves (32.0 ± 8.2 hr* μg/mL). Clearance (CL/F) of danofloxacin was higher in 6-month old calves. In contrast, tulathromycin plasma concentrations were higher in 6 month old calves and CL/F was higher in 3-week old calves. Age did not significantly influence the ISF concentrations of danofloxacin or tulathromycin in calves with respiratory disease, unlike previous studies which reported higher ISF concentrations of danofloxacin and tulathromycin in 6-month old calves when compared to younger calves. PELF concentrations were higher than plasma and ISF for both danofloxacin and tulathromycin, but did not differ between age groups. Potential reasons for age-related differences on plasma concentration-time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored.</description><subject>Age</subject><subject>Age Factors</subject><subject>Alveoli</subject><subject>Analysis</subject><subject>Animals</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Area Under Curve</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Beef cattle</subject><subject>Biology and Life Sciences</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchus</subject><subject>Calves</subject><subject>Cattle</subject><subject>Cattle Diseases - drug therapy</subject><subject>Chronology</subject><subject>Dilution</subject><subject>Disaccharides - administration & dosage</subject><subject>Disaccharides - pharmacokinetics</subject><subject>Disease</subject><subject>Disease control</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Extracellular Fluid - chemistry</subject><subject>Female</subject><subject>Fluoroquinolones - administration & dosage</subject><subject>Fluoroquinolones - pharmacokinetics</subject><subject>Gram-negative bacteria</subject><subject>Heterocyclic Compounds - administration & dosage</subject><subject>Heterocyclic Compounds - pharmacokinetics</subject><subject>Impact analysis</subject><subject>Infections</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Medical research</subject><subject>Medical treatment</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Pasteurella Infections - drug therapy</subject><subject>Pasteurella Infections - veterinary</subject><subject>Pasteurella multocida - pathogenicity</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Plasma</subject><subject>Pneumonia</subject><subject>Population</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Respiration Disorders - drug therapy</subject><subject>Respiration Disorders - 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This study was undertaken to investigate the efficacy and PK of two antibiotics, tulathromycin and danofloxacin, in two age groups of calves experimentally infected with Pasteurella multocida. Both danofloxacin, a fluoroquinolone antibiotic, and tulathromycin, a macrolide antibiotic is approved for the treatment of bovine respiratory disease (BRD). To evaluate potential influences of age and disease on drug distribution and elimination in calves, plasma, interstitial fluid (ISF), and pulmonary epithelial lining fluid (PELF) were analyzed for drug concentrations. Concentrations for both drugs in the PELF were estimated by a urea dilution assay of the collected bronchoalveolar lavage fluids. Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters. For calves administered danofloxacin, the area under the curve (AUC) in the plasma was lower in 6-month old calves (18.9 ± 12.6 hr* μg/mL) vs. 3-week old calves (32.0 ± 8.2 hr* μg/mL). Clearance (CL/F) of danofloxacin was higher in 6-month old calves. In contrast, tulathromycin plasma concentrations were higher in 6 month old calves and CL/F was higher in 3-week old calves. Age did not significantly influence the ISF concentrations of danofloxacin or tulathromycin in calves with respiratory disease, unlike previous studies which reported higher ISF concentrations of danofloxacin and tulathromycin in 6-month old calves when compared to younger calves. PELF concentrations were higher than plasma and ISF for both danofloxacin and tulathromycin, but did not differ between age groups. Potential reasons for age-related differences on plasma concentration-time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31233558</pmid><doi>10.1371/journal.pone.0218864</doi><tpages>e0218864</tpages><orcidid>https://orcid.org/0000-0001-5700-8810</orcidid><orcidid>https://orcid.org/0000-0002-9834-2089</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-06, Vol.14 (6), p.e0218864 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2246222685 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Age Factors Alveoli Analysis Animals Antibacterial agents Antibiotics Area Under Curve Bacteria Bacterial infections Beef cattle Biology and Life Sciences Bronchoalveolar Lavage Fluid - chemistry Bronchus Calves Cattle Cattle Diseases - drug therapy Chronology Dilution Disaccharides - administration & dosage Disaccharides - pharmacokinetics Disease Disease control Drug dosages Enzymes Extracellular Fluid - chemistry Female Fluoroquinolones - administration & dosage Fluoroquinolones - pharmacokinetics Gram-negative bacteria Heterocyclic Compounds - administration & dosage Heterocyclic Compounds - pharmacokinetics Impact analysis Infections Lung diseases Lungs Medical research Medical treatment Medicine and Health Sciences Metabolism Pasteurella Infections - drug therapy Pasteurella Infections - veterinary Pasteurella multocida - pathogenicity Pharmacokinetics Pharmacology Plasma Pneumonia Population Prevalence studies (Epidemiology) Respiration Disorders - drug therapy Respiration Disorders - veterinary Respiratory diseases Urea Veterinary colleges Veterinary medicine |
| title | Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves |
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