Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis
Severe acute kidney injury (AKI) is associated with subsequent infection. Whether AKI followed by a return to baseline creatinine is associated with incident infection is unknown. We hypothesized that risk of both short and long term infection would be higher among patients with AKI and return to ba...
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| Veröffentlicht in: | PloS one 2019-06, Vol.14 (6), p.e0217935-e0217935 |
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| creator | Griffin, Benjamin R You, Zhiying Holmen, John SooHoo, Megan Gist, Katja M Colbert, James F Chonchol, Michel Faubel, Sarah Jovanovich, Anna |
| description | Severe acute kidney injury (AKI) is associated with subsequent infection. Whether AKI followed by a return to baseline creatinine is associated with incident infection is unknown.
We hypothesized that risk of both short and long term infection would be higher among patients with AKI and return to baseline creatinine than in propensity score matched peers without AKI in the year following a non-infectious hospital admission.
Retrospective, propensity score matched cohort study.
We identified 494 patients who were hospitalized between January 1, 1999 and December 31, 2009 and had AKI followed by return to baseline creatinine. These were propensity score matched to controls without AKI.
The predictor variable was AKI defined by International Classification of Diseases, Ninth Revision (ICD-9) codes and by the Kidney Disease Improving Global Outcomes definition, with return to baseline creatinine defined as a decrease in serum creatinine level to within 10% of the baseline value within 7 days of hospital discharge. The outcome variable was incident infection defined by ICD-9 code within 1 year of hospital discharge.
AKI followed by return to baseline creatinine was associated with a 4.5-fold increased odds ratio for infection (odds ratio 4.53 [95% CI, 2.43-8.45]; p |
| doi_str_mv | 10.1371/journal.pone.0217935 |
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We hypothesized that risk of both short and long term infection would be higher among patients with AKI and return to baseline creatinine than in propensity score matched peers without AKI in the year following a non-infectious hospital admission.
Retrospective, propensity score matched cohort study.
We identified 494 patients who were hospitalized between January 1, 1999 and December 31, 2009 and had AKI followed by return to baseline creatinine. These were propensity score matched to controls without AKI.
The predictor variable was AKI defined by International Classification of Diseases, Ninth Revision (ICD-9) codes and by the Kidney Disease Improving Global Outcomes definition, with return to baseline creatinine defined as a decrease in serum creatinine level to within 10% of the baseline value within 7 days of hospital discharge. The outcome variable was incident infection defined by ICD-9 code within 1 year of hospital discharge.
AKI followed by return to baseline creatinine was associated with a 4.5-fold increased odds ratio for infection (odds ratio 4.53 [95% CI, 2.43-8.45]; p<0.0001) within 30 days following discharge. The association between AKI and subsequent infection remained significant at 31-60 days and 91 to 365 days but not during 61-90 days following discharge.
Among patients from an integrated health care delivery system, non-infectious AKI followed by return to baseline creatinine was associated with an increased odds ratio for infection in the year following discharge.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0217935</identifier><identifier>PMID: 31233518</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute kidney failure ; Acute Kidney Injury - blood ; Acute Kidney Injury - complications ; Biology and Life Sciences ; Care and treatment ; Case-Control Studies ; Chronic illnesses ; Creatinine ; Creatinine - blood ; Critical care ; Economic aspects ; Epidemiology ; Female ; Health care ; Health care costs ; Health care policy ; Hemodialysis ; Hospital admission and discharge ; Hospital patients ; Hospitalization ; Hospitals ; Humans ; Hypertension ; Infection ; Infections ; Infections - blood ; Infections - complications ; Infectious diseases ; Injury analysis ; Kidney diseases ; Kidneys ; Male ; Matched-Pair Analysis ; Medicine and Health Sciences ; Middle Aged ; Morbidity ; Mortality ; Nephrology ; Patient outcomes ; Patients ; Pediatrics ; Propensity Score ; Recovery (Medical) ; Renal replacement therapy ; Sepsis ; Studies ; Surgery ; Survival Analysis</subject><ispartof>PloS one, 2019-06, Vol.14 (6), p.e0217935-e0217935</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ac592f42cc1aee15dd11f9ef3bb6325ba9a8455a09981d56e38794040dd0f9563</citedby><cites>FETCH-LOGICAL-c692t-ac592f42cc1aee15dd11f9ef3bb6325ba9a8455a09981d56e38794040dd0f9563</cites><orcidid>0000-0003-1852-5174 ; 0000-0001-9416-453X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590794/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590794/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31233518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chan, Micah</contributor><creatorcontrib>Griffin, Benjamin R</creatorcontrib><creatorcontrib>You, Zhiying</creatorcontrib><creatorcontrib>Holmen, John</creatorcontrib><creatorcontrib>SooHoo, Megan</creatorcontrib><creatorcontrib>Gist, Katja M</creatorcontrib><creatorcontrib>Colbert, James F</creatorcontrib><creatorcontrib>Chonchol, Michel</creatorcontrib><creatorcontrib>Faubel, Sarah</creatorcontrib><creatorcontrib>Jovanovich, Anna</creatorcontrib><title>Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Severe acute kidney injury (AKI) is associated with subsequent infection. Whether AKI followed by a return to baseline creatinine is associated with incident infection is unknown.
We hypothesized that risk of both short and long term infection would be higher among patients with AKI and return to baseline creatinine than in propensity score matched peers without AKI in the year following a non-infectious hospital admission.
Retrospective, propensity score matched cohort study.
We identified 494 patients who were hospitalized between January 1, 1999 and December 31, 2009 and had AKI followed by return to baseline creatinine. These were propensity score matched to controls without AKI.
The predictor variable was AKI defined by International Classification of Diseases, Ninth Revision (ICD-9) codes and by the Kidney Disease Improving Global Outcomes definition, with return to baseline creatinine defined as a decrease in serum creatinine level to within 10% of the baseline value within 7 days of hospital discharge. The outcome variable was incident infection defined by ICD-9 code within 1 year of hospital discharge.
AKI followed by return to baseline creatinine was associated with a 4.5-fold increased odds ratio for infection (odds ratio 4.53 [95% CI, 2.43-8.45]; p<0.0001) within 30 days following discharge. The association between AKI and subsequent infection remained significant at 31-60 days and 91 to 365 days but not during 61-90 days following discharge.
Among patients from an integrated health care delivery system, non-infectious AKI followed by return to baseline creatinine was associated with an increased odds ratio for infection in the year following discharge.</description><subject>Acute kidney failure</subject><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - complications</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Chronic illnesses</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Critical care</subject><subject>Economic aspects</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health care</subject><subject>Health care costs</subject><subject>Health care policy</subject><subject>Hemodialysis</subject><subject>Hospital admission and discharge</subject><subject>Hospital patients</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infection</subject><subject>Infections</subject><subject>Infections - blood</subject><subject>Infections - complications</subject><subject>Infectious diseases</subject><subject>Injury analysis</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Propensity Score</subject><subject>Recovery (Medical)</subject><subject>Renal replacement therapy</subject><subject>Sepsis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Survival Analysis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkJw0eKPOIm5QKomPipNmsTXreXaJ61Lahfb2Si_HpdmU4N2QXIR23ne9xwf-xTFU4KnhNXkzdr3waluuvUOppiSWjB-rzglgtFJRTG7fzQ-KR7FuMaYs6aqHhYnjFDGOGlOi99zp60Bl5B1LehkvUOt7zp_bd0SKd0nQD-scbDLwLoPO3Rt0woF0P4K8ix5tFAROusA6QAqWZeHb9EMbYPfgos27VDUPgDaqKRXYJDKWe-ijY-LB63qIjwZvmfFtw_vv55_mlxcfpyfzy4muhI0TZTmgrYl1ZooAMKNIaQV0LLFomKUL5RQTcm5wkI0xPAKWFOLEpfYGNwKXrGz4vnBd9v5KIeyRUlpWdH8sDIT8wNhvFrLbbAbFXbSKyv_LviwlCokqzuQnAtW17iiC1WVWaxIw0xTN4xwZSjn2evdEK1fbMDoXNqgupHp-I-zK7n0V7LiAufEs8GrwSD4nz3EJDc2aug65cD3h7wFZkLUGX3xD3r37gZqqfIG8jH7HFfvTeUsx-Q1reiemt5B5dfAxup8x1qb10eC1yNBZhL8SkvVxyjnXz7_P3v5fcy-PGJXoLq0ir7r91czjsHyAOrgYwzQ3haZYLlvkZtqyH2LyKFFsuzZ8QHdim56gv0BwEYMdw</recordid><startdate>20190624</startdate><enddate>20190624</enddate><creator>Griffin, Benjamin R</creator><creator>You, Zhiying</creator><creator>Holmen, John</creator><creator>SooHoo, Megan</creator><creator>Gist, Katja M</creator><creator>Colbert, James F</creator><creator>Chonchol, Michel</creator><creator>Faubel, Sarah</creator><creator>Jovanovich, Anna</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1852-5174</orcidid><orcidid>https://orcid.org/0000-0001-9416-453X</orcidid></search><sort><creationdate>20190624</creationdate><title>Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis</title><author>Griffin, Benjamin R ; You, Zhiying ; Holmen, John ; SooHoo, Megan ; Gist, Katja M ; Colbert, James F ; Chonchol, Michel ; Faubel, Sarah ; Jovanovich, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ac592f42cc1aee15dd11f9ef3bb6325ba9a8455a09981d56e38794040dd0f9563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute kidney failure</topic><topic>Acute Kidney Injury - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Griffin, Benjamin R</au><au>You, Zhiying</au><au>Holmen, John</au><au>SooHoo, Megan</au><au>Gist, Katja M</au><au>Colbert, James F</au><au>Chonchol, Michel</au><au>Faubel, Sarah</au><au>Jovanovich, Anna</au><au>Chan, Micah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-06-24</date><risdate>2019</risdate><volume>14</volume><issue>6</issue><spage>e0217935</spage><epage>e0217935</epage><pages>e0217935-e0217935</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Severe acute kidney injury (AKI) is associated with subsequent infection. Whether AKI followed by a return to baseline creatinine is associated with incident infection is unknown.
We hypothesized that risk of both short and long term infection would be higher among patients with AKI and return to baseline creatinine than in propensity score matched peers without AKI in the year following a non-infectious hospital admission.
Retrospective, propensity score matched cohort study.
We identified 494 patients who were hospitalized between January 1, 1999 and December 31, 2009 and had AKI followed by return to baseline creatinine. These were propensity score matched to controls without AKI.
The predictor variable was AKI defined by International Classification of Diseases, Ninth Revision (ICD-9) codes and by the Kidney Disease Improving Global Outcomes definition, with return to baseline creatinine defined as a decrease in serum creatinine level to within 10% of the baseline value within 7 days of hospital discharge. The outcome variable was incident infection defined by ICD-9 code within 1 year of hospital discharge.
AKI followed by return to baseline creatinine was associated with a 4.5-fold increased odds ratio for infection (odds ratio 4.53 [95% CI, 2.43-8.45]; p<0.0001) within 30 days following discharge. The association between AKI and subsequent infection remained significant at 31-60 days and 91 to 365 days but not during 61-90 days following discharge.
Among patients from an integrated health care delivery system, non-infectious AKI followed by return to baseline creatinine was associated with an increased odds ratio for infection in the year following discharge.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31233518</pmid><doi>10.1371/journal.pone.0217935</doi><tpages>e0217935</tpages><orcidid>https://orcid.org/0000-0003-1852-5174</orcidid><orcidid>https://orcid.org/0000-0001-9416-453X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-06, Vol.14 (6), p.e0217935-e0217935 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2246222234 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acute kidney failure Acute Kidney Injury - blood Acute Kidney Injury - complications Biology and Life Sciences Care and treatment Case-Control Studies Chronic illnesses Creatinine Creatinine - blood Critical care Economic aspects Epidemiology Female Health care Health care costs Health care policy Hemodialysis Hospital admission and discharge Hospital patients Hospitalization Hospitals Humans Hypertension Infection Infections Infections - blood Infections - complications Infectious diseases Injury analysis Kidney diseases Kidneys Male Matched-Pair Analysis Medicine and Health Sciences Middle Aged Morbidity Mortality Nephrology Patient outcomes Patients Pediatrics Propensity Score Recovery (Medical) Renal replacement therapy Sepsis Studies Surgery Survival Analysis |
| title | Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T03%3A03%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incident%20infection%20following%20acute%20kidney%20injury%20with%20recovery%20to%20baseline%20creatinine:%20A%20propensity%20score%20matched%20analysis&rft.jtitle=PloS%20one&rft.au=Griffin,%20Benjamin%20R&rft.date=2019-06-24&rft.volume=14&rft.issue=6&rft.spage=e0217935&rft.epage=e0217935&rft.pages=e0217935-e0217935&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0217935&rft_dat=%3Cgale_plos_%3EA590572624%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2246222234&rft_id=info:pmid/31233518&rft_galeid=A590572624&rft_doaj_id=oai_doaj_org_article_559377062ba64223a183d878315ad255&rfr_iscdi=true |