Association between body mass index and 1-year outcome after acute myocardial infarction
Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as "Body Mass Index (BMI) paradox". However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomes after AMI. Among 13...
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creator | Kim, Dae-Won Her, Sung-Ho Park, Ha Wook Park, Mahn-Won Chang, Kiyuk Chung, Wook Sung Seung, Ki Bae Ahn, Tae Hoon Jeong, Myung Ho Rha, Seung-Woon Kim, Hyo-Soo Gwon, Hyeon Cheol Seong, In Whan Hwang, Kyung Kuk Chae, Shung Chull Kim, Kwon-Bae Kim, Young Jo Cha, Kwang Soo Oh, Seok Kyu Chae, Jei Keon |
description | Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as "Body Mass Index (BMI) paradox". However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomes after AMI.
Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group 1; < 22 kg/m2, 22 ≤ Group 2 < 26 kg/m2, Group 3; ≥ 26 kg/m2). The primary end point was all cause death at 1 year.
Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazard ratio [aHR], 1.537; 95% confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially, cardiac death played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p = 0.007).
Higher BMI appeared to be good prognostic factor on 1-year all cause death after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the life-quality after AMI. |
doi_str_mv | 10.1371/journal.pone.0217525 |
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Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group 1; < 22 kg/m2, 22 ≤ Group 2 < 26 kg/m2, Group 3; ≥ 26 kg/m2). The primary end point was all cause death at 1 year.
Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazard ratio [aHR], 1.537; 95% confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially, cardiac death played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p = 0.007).
Higher BMI appeared to be good prognostic factor on 1-year all cause death after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the life-quality after AMI.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0217525</identifier><identifier>PMID: 31199840</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Biology and Life Sciences ; Body mass ; Body Mass Index ; Body size ; Body weight ; Cardiology ; Cardiovascular disease ; Clinical trials ; Clopidogrel ; Collaboration ; Confidence intervals ; Coronary vessels ; Death ; Diabetes ; Disease-Free Survival ; Drug dosages ; Epidemiology ; Female ; Follow-Up Studies ; Health ; Health aspects ; Heart ; Heart attack ; Heart attacks ; Heart failure ; Hospitals ; Humans ; Intervention ; Male ; Medical equipment ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Myocardial infarction ; Myocardial Infarction - mortality ; Obesity ; Obesity - mortality ; Overweight ; Patient outcomes ; Prasugrel ; Prospective Studies ; Registries ; Republic of Korea - epidemiology ; Survival Rate ; Systematic review ; Ticagrelor</subject><ispartof>PloS one, 2019-06, Vol.14 (6), p.e0217525-e0217525</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Kim et al 2019 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-a8778457aefe0486b607d4381a3598a49414c32b3879c7f6dfbf511770e07d0e3</citedby><cites>FETCH-LOGICAL-c758t-a8778457aefe0486b607d4381a3598a49414c32b3879c7f6dfbf511770e07d0e3</cites><orcidid>0000-0002-1548-4154</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570024/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570024/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31199840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Dae-Won</creatorcontrib><creatorcontrib>Her, Sung-Ho</creatorcontrib><creatorcontrib>Park, Ha Wook</creatorcontrib><creatorcontrib>Park, Mahn-Won</creatorcontrib><creatorcontrib>Chang, Kiyuk</creatorcontrib><creatorcontrib>Chung, Wook Sung</creatorcontrib><creatorcontrib>Seung, Ki Bae</creatorcontrib><creatorcontrib>Ahn, Tae Hoon</creatorcontrib><creatorcontrib>Jeong, Myung Ho</creatorcontrib><creatorcontrib>Rha, Seung-Woon</creatorcontrib><creatorcontrib>Kim, Hyo-Soo</creatorcontrib><creatorcontrib>Gwon, Hyeon Cheol</creatorcontrib><creatorcontrib>Seong, In Whan</creatorcontrib><creatorcontrib>Hwang, Kyung Kuk</creatorcontrib><creatorcontrib>Chae, Shung Chull</creatorcontrib><creatorcontrib>Kim, Kwon-Bae</creatorcontrib><creatorcontrib>Kim, Young Jo</creatorcontrib><creatorcontrib>Cha, Kwang Soo</creatorcontrib><creatorcontrib>Oh, Seok Kyu</creatorcontrib><creatorcontrib>Chae, Jei Keon</creatorcontrib><creatorcontrib>KAMIR-NIH registry investigators</creatorcontrib><creatorcontrib>on behalf of KAMIR-NIH registry investigators</creatorcontrib><title>Association between body mass index and 1-year outcome after acute myocardial infarction</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as "Body Mass Index (BMI) paradox". However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomes after AMI.
Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group 1; < 22 kg/m2, 22 ≤ Group 2 < 26 kg/m2, Group 3; ≥ 26 kg/m2). The primary end point was all cause death at 1 year.
Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazard ratio [aHR], 1.537; 95% confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially, cardiac death played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p = 0.007).
Higher BMI appeared to be good prognostic factor on 1-year all cause death after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the life-quality after AMI.</description><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Clinical trials</subject><subject>Clopidogrel</subject><subject>Collaboration</subject><subject>Confidence intervals</subject><subject>Coronary vessels</subject><subject>Death</subject><subject>Diabetes</subject><subject>Disease-Free Survival</subject><subject>Drug dosages</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart attack</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intervention</subject><subject>Male</subject><subject>Medical equipment</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - mortality</subject><subject>Obesity</subject><subject>Obesity - mortality</subject><subject>Overweight</subject><subject>Patient outcomes</subject><subject>Prasugrel</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Republic of Korea - epidemiology</subject><subject>Survival Rate</subject><subject>Systematic review</subject><subject>Ticagrelor</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-L1DAQx4so3nn6H4gWBNGHXZMmadIXYTn8sXBw4C98C9N0utujbdYk1dv_3vS2d2zlHiQPE5LPfCczmUmS55QsKZP03ZUdXA_tcmd7XJKMSpGJB8kpLVi2yDPCHh7tT5In3l8RIpjK88fJCaO0KBQnp8nPlffWNBAa26clhj-I0dpqn3bgfdr0FV6n0FcpXewRXGqHYGyHKdQBXQpmCJh2e2vAVQ20ka_BmVHsafKohtbjs8meJd8_fvh2_nlxcflpfb66WBgpVFiAklJxIQFrJFzlZU5kxZmiwEShgBeccsOykilZGFnnVV3WglIpCUaQIDtLXh50d631eiqK11nGCSOEKBqJ9YGoLFzpnWs6cHttodE3B9ZtNLjQmBY18AxpUWPJRcmNlCUtJMdSMixUhjhGez9FG8oOK4N9cNDOROc3fbPVG_tb50ISkvEo8GYScPbXgD7orvEG2xZ6tMPNu0UuGKHju1_9g96f3URtICYQ629jXDOK6pVQBZFZIVSklvdQcVXYNSZ2UN3E85nD25lDZAJehw0M3uv11y__z17-mLOvj9gtQhu23rbD2DJ-DvIDaJz13mF9V2RK9DgAt9XQ4wDoaQCi24vjD7pzuu149hezgP-7</recordid><startdate>20190614</startdate><enddate>20190614</enddate><creator>Kim, 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between body mass index and 1-year outcome after acute myocardial infarction</title><author>Kim, Dae-Won ; Her, Sung-Ho ; Park, Ha Wook ; Park, Mahn-Won ; Chang, Kiyuk ; Chung, Wook Sung ; Seung, Ki Bae ; Ahn, Tae Hoon ; Jeong, Myung Ho ; Rha, Seung-Woon ; Kim, Hyo-Soo ; Gwon, Hyeon Cheol ; Seong, In Whan ; Hwang, Kyung Kuk ; Chae, Shung Chull ; Kim, Kwon-Bae ; Kim, Young Jo ; Cha, Kwang Soo ; Oh, Seok Kyu ; Chae, Jei Keon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-a8778457aefe0486b607d4381a3598a49414c32b3879c7f6dfbf511770e07d0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Clinical trials</topic><topic>Clopidogrel</topic><topic>Collaboration</topic><topic>Confidence intervals</topic><topic>Coronary vessels</topic><topic>Death</topic><topic>Diabetes</topic><topic>Disease-Free Survival</topic><topic>Drug dosages</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health</topic><topic>Health aspects</topic><topic>Heart</topic><topic>Heart attack</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Intervention</topic><topic>Male</topic><topic>Medical equipment</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - mortality</topic><topic>Obesity</topic><topic>Obesity - mortality</topic><topic>Overweight</topic><topic>Patient outcomes</topic><topic>Prasugrel</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Republic of Korea - epidemiology</topic><topic>Survival Rate</topic><topic>Systematic review</topic><topic>Ticagrelor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Dae-Won</creatorcontrib><creatorcontrib>Her, Sung-Ho</creatorcontrib><creatorcontrib>Park, Ha Wook</creatorcontrib><creatorcontrib>Park, Mahn-Won</creatorcontrib><creatorcontrib>Chang, Kiyuk</creatorcontrib><creatorcontrib>Chung, Wook Sung</creatorcontrib><creatorcontrib>Seung, Ki Bae</creatorcontrib><creatorcontrib>Ahn, Tae Hoon</creatorcontrib><creatorcontrib>Jeong, Myung Ho</creatorcontrib><creatorcontrib>Rha, Seung-Woon</creatorcontrib><creatorcontrib>Kim, Hyo-Soo</creatorcontrib><creatorcontrib>Gwon, Hyeon Cheol</creatorcontrib><creatorcontrib>Seong, In Whan</creatorcontrib><creatorcontrib>Hwang, Kyung Kuk</creatorcontrib><creatorcontrib>Chae, Shung Chull</creatorcontrib><creatorcontrib>Kim, 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Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Dae-Won</au><au>Her, Sung-Ho</au><au>Park, Ha Wook</au><au>Park, Mahn-Won</au><au>Chang, Kiyuk</au><au>Chung, Wook Sung</au><au>Seung, Ki Bae</au><au>Ahn, Tae Hoon</au><au>Jeong, Myung Ho</au><au>Rha, Seung-Woon</au><au>Kim, Hyo-Soo</au><au>Gwon, Hyeon Cheol</au><au>Seong, In Whan</au><au>Hwang, Kyung Kuk</au><au>Chae, Shung Chull</au><au>Kim, Kwon-Bae</au><au>Kim, Young Jo</au><au>Cha, Kwang Soo</au><au>Oh, Seok Kyu</au><au>Chae, Jei Keon</au><aucorp>KAMIR-NIH registry investigators</aucorp><aucorp>on behalf of KAMIR-NIH registry investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between body mass index and 1-year outcome after acute myocardial infarction</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-06-14</date><risdate>2019</risdate><volume>14</volume><issue>6</issue><spage>e0217525</spage><epage>e0217525</epage><pages>e0217525-e0217525</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as "Body Mass Index (BMI) paradox". However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomes after AMI.
Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group 1; < 22 kg/m2, 22 ≤ Group 2 < 26 kg/m2, Group 3; ≥ 26 kg/m2). The primary end point was all cause death at 1 year.
Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazard ratio [aHR], 1.537; 95% confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially, cardiac death played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p = 0.007).
Higher BMI appeared to be good prognostic factor on 1-year all cause death after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the life-quality after AMI.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31199840</pmid><doi>10.1371/journal.pone.0217525</doi><tpages>e0217525</tpages><orcidid>https://orcid.org/0000-0002-1548-4154</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2019-06, Vol.14 (6), p.e0217525-e0217525 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_2240300081 |
source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
subjects | Aged Biology and Life Sciences Body mass Body Mass Index Body size Body weight Cardiology Cardiovascular disease Clinical trials Clopidogrel Collaboration Confidence intervals Coronary vessels Death Diabetes Disease-Free Survival Drug dosages Epidemiology Female Follow-Up Studies Health Health aspects Heart Heart attack Heart attacks Heart failure Hospitals Humans Intervention Male Medical equipment Medical research Medicine and Health Sciences Middle Aged Mortality Myocardial infarction Myocardial Infarction - mortality Obesity Obesity - mortality Overweight Patient outcomes Prasugrel Prospective Studies Registries Republic of Korea - epidemiology Survival Rate Systematic review Ticagrelor |
title | Association between body mass index and 1-year outcome after acute myocardial infarction |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A20%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20body%20mass%20index%20and%201-year%20outcome%20after%20acute%20myocardial%20infarction&rft.jtitle=PloS%20one&rft.au=Kim,%20Dae-Won&rft.aucorp=KAMIR-NIH%20registry%20investigators&rft.date=2019-06-14&rft.volume=14&rft.issue=6&rft.spage=e0217525&rft.epage=e0217525&rft.pages=e0217525-e0217525&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0217525&rft_dat=%3Cgale_plos_%3EA589072958%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2240300081&rft_id=info:pmid/31199840&rft_galeid=A589072958&rft_doaj_id=oai_doaj_org_article_a42e19feb45b4c77b1974eb73e982eee&rfr_iscdi=true |