Effect of cyclic deformation on xenogeneic heart valve biomaterials
Glutaraldehyde-fixed bovine pericardium is currently the most popular biomaterial utilized in the creation of bioprosthetic heart valves. However, recent studies indicate that glutaraldehyde fixation results in calcification and structural valve deterioration, limiting the longevity of bioprosthetic...
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| description | Glutaraldehyde-fixed bovine pericardium is currently the most popular biomaterial utilized in the creation of bioprosthetic heart valves. However, recent studies indicate that glutaraldehyde fixation results in calcification and structural valve deterioration, limiting the longevity of bioprosthetic heart valves. Additionally, glutaraldehyde fixation renders the tissue incompatible with constructive recipient cellular repopulation, remodeling and growth. Use of unfixed xenogeneic biomaterials devoid of antigenic burden has potential to overcome the limitations of current glutaraldehyde-fixed biomaterials. Heart valves undergo billion cycles of opening and closing throughout the patient's lifetime. Therefore, understanding the response of unfixed tissues to cyclic loading is crucial to these in a heart valve leaflet configuration. In this manuscript we quantify the effect of cyclic deformation on cycle dependent strain, structural, compositional and mechanical properties of fixed and unfixed tissues. Glutaraldehyde-fixed bovine pericardium underwent marked cyclic dependent strain, resulting from significant changes in structure, composition and mechanical function of the material. Conversely, unfixed bovine pericardium underwent minimal strain and maintained its structure, composition and mechanical integrity. This manuscript demonstrates that unfixed bovine pericardium can withstand cyclic deformations equivalent to 6 months of in vivo heart valve leaflet performance. |
| doi_str_mv | 10.1371/journal.pone.0214656 |
| format | Article |
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However, recent studies indicate that glutaraldehyde fixation results in calcification and structural valve deterioration, limiting the longevity of bioprosthetic heart valves. Additionally, glutaraldehyde fixation renders the tissue incompatible with constructive recipient cellular repopulation, remodeling and growth. Use of unfixed xenogeneic biomaterials devoid of antigenic burden has potential to overcome the limitations of current glutaraldehyde-fixed biomaterials. Heart valves undergo billion cycles of opening and closing throughout the patient's lifetime. Therefore, understanding the response of unfixed tissues to cyclic loading is crucial to these in a heart valve leaflet configuration. In this manuscript we quantify the effect of cyclic deformation on cycle dependent strain, structural, compositional and mechanical properties of fixed and unfixed tissues. Glutaraldehyde-fixed bovine pericardium underwent marked cyclic dependent strain, resulting from significant changes in structure, composition and mechanical function of the material. Conversely, unfixed bovine pericardium underwent minimal strain and maintained its structure, composition and mechanical integrity. This manuscript demonstrates that unfixed bovine pericardium can withstand cyclic deformations equivalent to 6 months of in vivo heart valve leaflet performance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0214656</identifier><identifier>PMID: 31194770</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antigens ; Artificial heart valves ; Beef cattle ; Biological products ; Biology and Life Sciences ; Biomaterials ; Biomechanical Phenomena - drug effects ; Biomedical materials ; Bioprosthesis ; Calcification ; Calcification (ectopic) ; Calcification (Physiology) ; Care and treatment ; Catheters ; Cattle ; Collagen ; Composition ; Cyclic loads ; Deformation ; Deformation effects ; Engineering and Technology ; Extracellular matrix ; Finite Element Analysis ; Fixation ; Glutaral - pharmacology ; Glutaraldehyde ; Health aspects ; Heart ; Heart valve diseases ; Heart Valve Prosthesis ; Heart valves ; Heart Valves - drug effects ; Heart Valves - physiology ; Laboratory animals ; Materials ; Mechanical properties ; Medicine and Health Sciences ; Organ Preservation - veterinary ; Patient outcomes ; Pericardium ; Physical Sciences ; Polymer crosslinking ; Repopulation ; Swine ; Tissue engineering ; Tissue Fixation ; Viscoelasticity</subject><ispartof>PloS one, 2019-06, Vol.14 (6), p.e0214656-e0214656</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Dalgliesh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Dalgliesh et al 2019 Dalgliesh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f70ff493d82c5da1e3499f0df59fe33403aa3a055a942f2b352e0294d506bca73</citedby><cites>FETCH-LOGICAL-c692t-f70ff493d82c5da1e3499f0df59fe33403aa3a055a942f2b352e0294d506bca73</cites><orcidid>0000-0001-6147-5972</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563958/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563958/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31194770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pelacho, Beatriz</contributor><creatorcontrib>Dalgliesh, Ailsa J</creatorcontrib><creatorcontrib>Parvizi, Mojtaba</creatorcontrib><creatorcontrib>Noble, Christopher</creatorcontrib><creatorcontrib>Griffiths, Leigh G</creatorcontrib><title>Effect of cyclic deformation on xenogeneic heart valve biomaterials</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Glutaraldehyde-fixed bovine pericardium is currently the most popular biomaterial utilized in the creation of bioprosthetic heart valves. However, recent studies indicate that glutaraldehyde fixation results in calcification and structural valve deterioration, limiting the longevity of bioprosthetic heart valves. Additionally, glutaraldehyde fixation renders the tissue incompatible with constructive recipient cellular repopulation, remodeling and growth. Use of unfixed xenogeneic biomaterials devoid of antigenic burden has potential to overcome the limitations of current glutaraldehyde-fixed biomaterials. Heart valves undergo billion cycles of opening and closing throughout the patient's lifetime. Therefore, understanding the response of unfixed tissues to cyclic loading is crucial to these in a heart valve leaflet configuration. In this manuscript we quantify the effect of cyclic deformation on cycle dependent strain, structural, compositional and mechanical properties of fixed and unfixed tissues. Glutaraldehyde-fixed bovine pericardium underwent marked cyclic dependent strain, resulting from significant changes in structure, composition and mechanical function of the material. Conversely, unfixed bovine pericardium underwent minimal strain and maintained its structure, composition and mechanical integrity. This manuscript demonstrates that unfixed bovine pericardium can withstand cyclic deformations equivalent to 6 months of in vivo heart valve leaflet performance.</description><subject>Animals</subject><subject>Antigens</subject><subject>Artificial heart valves</subject><subject>Beef cattle</subject><subject>Biological products</subject><subject>Biology and Life Sciences</subject><subject>Biomaterials</subject><subject>Biomechanical Phenomena - drug effects</subject><subject>Biomedical materials</subject><subject>Bioprosthesis</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Calcification (Physiology)</subject><subject>Care and treatment</subject><subject>Catheters</subject><subject>Cattle</subject><subject>Collagen</subject><subject>Composition</subject><subject>Cyclic loads</subject><subject>Deformation</subject><subject>Deformation effects</subject><subject>Engineering and Technology</subject><subject>Extracellular matrix</subject><subject>Finite Element Analysis</subject><subject>Fixation</subject><subject>Glutaral - pharmacology</subject><subject>Glutaraldehyde</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart valve diseases</subject><subject>Heart Valve Prosthesis</subject><subject>Heart valves</subject><subject>Heart Valves - drug effects</subject><subject>Heart Valves - physiology</subject><subject>Laboratory animals</subject><subject>Materials</subject><subject>Mechanical properties</subject><subject>Medicine and Health Sciences</subject><subject>Organ Preservation - veterinary</subject><subject>Patient outcomes</subject><subject>Pericardium</subject><subject>Physical Sciences</subject><subject>Polymer crosslinking</subject><subject>Repopulation</subject><subject>Swine</subject><subject>Tissue engineering</subject><subject>Tissue Fixation</subject><subject>Viscoelasticity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2LEzEUhgdR3LX6D0QHBNGL1nzP5EZYyqqFhQW_bkOanLQp00k3mSm7_97Uzi4d2QtJICF5znvOSd6ieI3RDNMKf9qEPra6me1CCzNEMBNcPCnOsaRkKgiiT0_2Z8WLlDYIcVoL8bw4oxhLVlXovJhfOgemK4MrzZ1pvCktuBC3uvOhLfO8hTasoIV8swYdu3Kvmz2USx8yA9HrJr0snrm8wKthnRS_vlz-nH-bXl1_XcwvrqZGSNJNXYWcY5LamhhuNQbKpHTIOi4dUMoQ1ZpqxLmWjDiypJwAIpJZjsTS6IpOirdH3V0Tkhr6T4oQKoWgVUUzsTgSNuiN2kW_1fFOBe3V34MQVyq34E0DCllSW8ahtnXNsGXaICpcTbjNpdS5kknxecjWL7dgDbRd1M1IdHzT-rVahb3K_0Alr7PAh0EghpseUqe2PhloGt1C6A91My44EURk9N0_6OPdDdRK5wZ860LOaw6i6oLXtSQMc5Sp2SNUHha23mSzOJ_PRwEfRwGZ6eC2W-k-JbX48f3_2evfY_b9CZvN03TrFJr-4Kw0BtkRNDGkFME9PDJG6uD1-9dQB6-rwes57M3pBz0E3Zub_gHIAPgs</recordid><startdate>20190613</startdate><enddate>20190613</enddate><creator>Dalgliesh, Ailsa J</creator><creator>Parvizi, Mojtaba</creator><creator>Noble, Christopher</creator><creator>Griffiths, Leigh G</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6147-5972</orcidid></search><sort><creationdate>20190613</creationdate><title>Effect of cyclic deformation on xenogeneic heart valve biomaterials</title><author>Dalgliesh, Ailsa J ; Parvizi, Mojtaba ; Noble, Christopher ; Griffiths, Leigh G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-f70ff493d82c5da1e3499f0df59fe33403aa3a055a942f2b352e0294d506bca73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Artificial heart valves</topic><topic>Beef cattle</topic><topic>Biological products</topic><topic>Biology and Life Sciences</topic><topic>Biomaterials</topic><topic>Biomechanical Phenomena - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalgliesh, Ailsa J</au><au>Parvizi, Mojtaba</au><au>Noble, Christopher</au><au>Griffiths, Leigh G</au><au>Pelacho, Beatriz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of cyclic deformation on xenogeneic heart valve biomaterials</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-06-13</date><risdate>2019</risdate><volume>14</volume><issue>6</issue><spage>e0214656</spage><epage>e0214656</epage><pages>e0214656-e0214656</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Glutaraldehyde-fixed bovine pericardium is currently the most popular biomaterial utilized in the creation of bioprosthetic heart valves. However, recent studies indicate that glutaraldehyde fixation results in calcification and structural valve deterioration, limiting the longevity of bioprosthetic heart valves. Additionally, glutaraldehyde fixation renders the tissue incompatible with constructive recipient cellular repopulation, remodeling and growth. Use of unfixed xenogeneic biomaterials devoid of antigenic burden has potential to overcome the limitations of current glutaraldehyde-fixed biomaterials. Heart valves undergo billion cycles of opening and closing throughout the patient's lifetime. Therefore, understanding the response of unfixed tissues to cyclic loading is crucial to these in a heart valve leaflet configuration. In this manuscript we quantify the effect of cyclic deformation on cycle dependent strain, structural, compositional and mechanical properties of fixed and unfixed tissues. Glutaraldehyde-fixed bovine pericardium underwent marked cyclic dependent strain, resulting from significant changes in structure, composition and mechanical function of the material. Conversely, unfixed bovine pericardium underwent minimal strain and maintained its structure, composition and mechanical integrity. This manuscript demonstrates that unfixed bovine pericardium can withstand cyclic deformations equivalent to 6 months of in vivo heart valve leaflet performance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31194770</pmid><doi>10.1371/journal.pone.0214656</doi><tpages>e0214656</tpages><orcidid>https://orcid.org/0000-0001-6147-5972</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Antigens Artificial heart valves Beef cattle Biological products Biology and Life Sciences Biomaterials Biomechanical Phenomena - drug effects Biomedical materials Bioprosthesis Calcification Calcification (ectopic) Calcification (Physiology) Care and treatment Catheters Cattle Collagen Composition Cyclic loads Deformation Deformation effects Engineering and Technology Extracellular matrix Finite Element Analysis Fixation Glutaral - pharmacology Glutaraldehyde Health aspects Heart Heart valve diseases Heart Valve Prosthesis Heart valves Heart Valves - drug effects Heart Valves - physiology Laboratory animals Materials Mechanical properties Medicine and Health Sciences Organ Preservation - veterinary Patient outcomes Pericardium Physical Sciences Polymer crosslinking Repopulation Swine Tissue engineering Tissue Fixation Viscoelasticity |
| title | Effect of cyclic deformation on xenogeneic heart valve biomaterials |
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