Overexpression of PODXL/ITGB1 and BCL7B/ITGB1 accurately predicts unfavorable prognosis compared to the TNM staging system in postoperative pancreatic cancer patients

We previously reported that overexpression of PODXL, BCL7B, and ARHGEF4 in pancreatic cancer tissue is correlated with pancreatic cancer-related survival. The aim of this study was to investigate the use of PODXL, BCL7B, ARHGEF4, and the integrin family member ITGB1 as useful markers for the prognos...

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Veröffentlicht in:	PloS one 2019-06, Vol.14 (6), p.e0217920-e0217920
Hauptverfasser:	Taniuchi, Keisuke, Furihata, Mutsuo, Naganuma, Seiji, Sakaguchi, Masahiko, Saibara, Toshiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies Biological markers Biology and Life Sciences Cancer Cancer metastasis Cancer patients Cancer research Cancer staging Cancer therapies Cell adhesion & migration Chemotherapy Confidence intervals Endoscopy Female Gastroenterology Genetic aspects Hazards Health hazards Hepatology Humans Immunohistochemistry Integrin beta1 - metabolism Integrins Kaplan-Meier Estimate Male Medical prognosis Medical schools Medicine and Health Sciences Metastases Metastasis Middle Aged Motility Multivariate Analysis Neoplasm Staging Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Patients Postoperative Period Prognosis Proportional Hazards Models Proteins Proteins - metabolism Regression analysis Research and Analysis Methods Rho Guanine Nucleotide Exchange Factors - metabolism Sialoglycoproteins - metabolism Statistical analysis Survival Systematic review Treatment Outcome Tumor Burden Tumors
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