Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer

Radium-223 is a targeted alpha-particle therapy that improves survival in men with metastatic castration resistant prostate cancer (mCRPC), particularly in men with elevated serum levels of bone alkaline phosphatase (B-ALP). We hypothesized that osteomimicry, a form of epithelial plasticity leading...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2019-05, Vol.14 (5), p.e0216934
Hauptverfasser:	Armstrong, Andrew J, Gupta, Santosh, Healy, Patrick, Kemeny, Gabor, Leith, Beth, Zalutsky, Michael R, Spritzer, Charles, Davies, Catrin, Rothwell, Colin, Ware, Kathryn, Somarelli, Jason A, Wood, Kris, Ribar, Thomas, Giannakakou, Paraskevi, Zhang, Jiaren, Gerber, Drew, Anand, Monika, Foo, Wen-Chi, Halabi, Susan, Gregory, Simon G, George, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abiraterone Aged Alkaline phosphatase Alkaline Phosphatase - blood Alkaline Phosphatase - genetics Alpha rays Biocompatibility Biology Biology and Life Sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical materials Biopsy Bone and Bones - metabolism Bone and Bones - pathology Bone and Bones - radiation effects Bone Neoplasms - genetics Bone Neoplasms - mortality Bone Neoplasms - radiotherapy Bone Neoplasms - secondary Bone tumors Cadherins Cadherins - genetics Cadherins - metabolism Cancer metastasis Cancer research Care and treatment Castration Cbfa-1 protein Cell cycle Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Denosumab Deoxyribonucleic acid Development and progression Disease Progression DNA DNA repair EDTA Enzalutamide Gene Expression Genes Genetic aspects Genomic analysis Humans Irradiation Levels Lymphocytes B Male Medicine Medicine and Health Sciences Metastases Metastasis Mimicry Molecular Targeted Therapy - methods Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Neoplastic Cells, Circulating - radiation effects Oncology Osteoblasts Osteonectin Osteonectin - genetics Osteonectin - metabolism Osteopontin Osteopontin - genetics Osteopontin - metabolism Pharmacodynamics Pharmacology Phenotypes Phenotypic plasticity Phosphatases Physiology Prostate - metabolism Prostate - pathology Prostate - radiation effects Prostate cancer Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - mortality Prostatic Neoplasms, Castration-Resistant - pathology Prostatic Neoplasms, Castration-Resistant - radiotherapy Radiation therapy Radioactivity Radiotherapy Radium Radium - blood Radium - pharmacokinetics Radium - therapeutic use Research and analysis methods Ribonucleic acid RNA Serum levels Survival Analysis Tumor Microenvironment - genetics Tumor Microenvironment - radiation effects Tumors Zoledronic acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!