Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity
Psoriasis vulgaris is a systemic disorder with an underlying immune dysregulation that predisposes to inflammatory skin lesions. Meanwhile, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against the deleterious effects of uncontrolled inflammation...
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| description | Psoriasis vulgaris is a systemic disorder with an underlying immune dysregulation that predisposes to inflammatory skin lesions. Meanwhile, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against the deleterious effects of uncontrolled inflammation. In this study, we compared the expression levels of TNFAIP3 in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. Additionally, the levels of TNFAIP3 protein in psoriatic skin biopsies were compared to those in normal individuals. Thirty psoriatic patients and 30 healthy participants (control group) were enrolled. The expression levels of TNFAIP3 in blood and skin were measured by quantitative reverse transcription PCR, while the skin levels of TNFAIP3 protein were measured by western blot. Psoriatic patients showed significantly lower expression levels of TNFAIP3 in psoriatic skin and blood (P< 0.001) as well as of TNFAIP3 protein in psoriatic skin (P< 0.001) compared to controls. A significant lower expression of TNFAIP3 and TNFAIP3 protein in psoriatic skin was detected in moderate/severe cases compared to mild cases (P = 0.004 and 0.003 respectively). Moreover, a significant negative correlation was found between TNFAIP3 mRNA in psoriatic tissue and psoriasis area severity index values (rs = -0.382, P-value = 0.037). In conclusion, TNFAIP3 may serve as a predictive and prognostic biomarker in psoriatic patients. Enhancing the expression and/or function of TNFAIP3 in the affected cell type may be a promising therapeutic strategy. |
| doi_str_mv | 10.1371/journal.pone.0217352 |
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Meanwhile, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against the deleterious effects of uncontrolled inflammation. In this study, we compared the expression levels of TNFAIP3 in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. Additionally, the levels of TNFAIP3 protein in psoriatic skin biopsies were compared to those in normal individuals. Thirty psoriatic patients and 30 healthy participants (control group) were enrolled. The expression levels of TNFAIP3 in blood and skin were measured by quantitative reverse transcription PCR, while the skin levels of TNFAIP3 protein were measured by western blot. Psoriatic patients showed significantly lower expression levels of TNFAIP3 in psoriatic skin and blood (P< 0.001) as well as of TNFAIP3 protein in psoriatic skin (P< 0.001) compared to controls. A significant lower expression of TNFAIP3 and TNFAIP3 protein in psoriatic skin was detected in moderate/severe cases compared to mild cases (P = 0.004 and 0.003 respectively). Moreover, a significant negative correlation was found between TNFAIP3 mRNA in psoriatic tissue and psoriasis area severity index values (rs = -0.382, P-value = 0.037). In conclusion, TNFAIP3 may serve as a predictive and prognostic biomarker in psoriatic patients. Enhancing the expression and/or function of TNFAIP3 in the affected cell type may be a promising therapeutic strategy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0217352</identifier><identifier>PMID: 31120955</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; B cells ; Bioindicators ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Biomarkers - metabolism ; Blood ; Care and treatment ; Case-Control Studies ; Cytokines ; Disease ; Disease Susceptibility ; EDTA ; Female ; Gene expression ; Genes ; Genetic aspects ; Genomes ; Humans ; Immunology ; Inflammation ; Lesions ; Leukemia ; Lymphocytes ; Male ; Medicine ; Medicine and Health Sciences ; Messenger RNA ; MicroRNAs ; Middle Aged ; Necrosis ; Pathogenesis ; Polymerase chain reaction ; Proteins ; Psoriasis ; Psoriasis - genetics ; Psoriasis - metabolism ; Psoriasis - pathology ; Psoriasis vulgaris ; Reverse Transcriptase Polymerase Chain Reaction ; Reverse transcription ; RNA ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Skin ; Skin - metabolism ; Skin - pathology ; Skin diseases ; Tumor necrosis factor ; Tumor Necrosis Factor alpha-Induced Protein 3 - blood ; Tumor Necrosis Factor alpha-Induced Protein 3 - genetics ; Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Tumors ; Ustekinumab ; Young Adult</subject><ispartof>PloS one, 2019-05, Vol.14 (5), p.e0217352-e0217352</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Sahlol et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Sahlol et al 2019 Sahlol et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-a7591face239cd8e7e3d8a658bf6f0c23857f7f2d35228b61f8ae623abb980c03</citedby><cites>FETCH-LOGICAL-c758t-a7591face239cd8e7e3d8a658bf6f0c23857f7f2d35228b61f8ae623abb980c03</cites><orcidid>0000-0002-8906-8938 ; 0000-0002-7849-3904</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532901/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532901/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31120955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rich, Benjamin Edward</contributor><creatorcontrib>Sahlol, Nahla Yassin</creatorcontrib><creatorcontrib>Mostafa, Marwa Salah</creatorcontrib><creatorcontrib>Madkour, Lamiaa Abd El-Fattah</creatorcontrib><creatorcontrib>Salama, Dina Metwally</creatorcontrib><title>Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Psoriasis vulgaris is a systemic disorder with an underlying immune dysregulation that predisposes to inflammatory skin lesions. Meanwhile, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against the deleterious effects of uncontrolled inflammation. In this study, we compared the expression levels of TNFAIP3 in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. Additionally, the levels of TNFAIP3 protein in psoriatic skin biopsies were compared to those in normal individuals. Thirty psoriatic patients and 30 healthy participants (control group) were enrolled. The expression levels of TNFAIP3 in blood and skin were measured by quantitative reverse transcription PCR, while the skin levels of TNFAIP3 protein were measured by western blot. Psoriatic patients showed significantly lower expression levels of TNFAIP3 in psoriatic skin and blood (P< 0.001) as well as of TNFAIP3 protein in psoriatic skin (P< 0.001) compared to controls. A significant lower expression of TNFAIP3 and TNFAIP3 protein in psoriatic skin was detected in moderate/severe cases compared to mild cases (P = 0.004 and 0.003 respectively). Moreover, a significant negative correlation was found between TNFAIP3 mRNA in psoriatic tissue and psoriasis area severity index values (rs = -0.382, P-value = 0.037). In conclusion, TNFAIP3 may serve as a predictive and prognostic biomarker in psoriatic patients. 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genetics</subject><subject>Psoriasis - metabolism</subject><subject>Psoriasis - pathology</subject><subject>Psoriasis vulgaris</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Reverse transcription</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Skin</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin diseases</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor alpha-Induced Protein 3 - blood</subject><subject>Tumor Necrosis Factor alpha-Induced Protein 3 - genetics</subject><subject>Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Tumors</subject><subject>Ustekinumab</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl9v0zAUxSMEYmPwDRBEQkLw0OI_sZ28IFUTg0oVQ7DxajnJdeuSxpntjO3b49BsatAekB9iO7977HN9kuQlRnNMBf6wtb1rVTPvbAtzRLCgjDxKjnFByYwTRB8fzI-SZ95vEWI05_xpckQxJqhg7Di5XNnf6cXXs8XyG03hpnPgvbFtatq089YZFUyV-l_D0tmdDeDT2nhQHlLf-wq6YErTmHCbqrZOPVyDi4vnyROtGg8vxu9Jcnn26eL0y2x1_nl5uljNKsHyMFOCFVirCggtqjoHAbTOFWd5qblGFaE5E1poUkdrJC851rkCTqgqyyJHFaInyeu9btdYL8eOeEkIKTilBSKRWO6J2qqt7JzZKXcrrTLy74Z1a6lc9NiAxJBprIEKQVVWZCQXolaCc8yIoqwQUevjeFpf7qCuoA1ONRPR6Z_WbOTaXkvOKCkQjgLvRgFnr3rwQe5M7GHTqBZsP9ybkvgwCA_O3vyDPuxupNYqGjCttvHcahCVC5bzjNCMD_eeP0DFUcPOVDE-2sT9ScH7SUFkAtyEteq9l8sf3_-fPf85Zd8esBtQTdh42_QhJs5PwWwPVs5670DfNxkjOaT_rhtySL8c0x_LXh0-0H3RXdzpHzKE_qc</recordid><startdate>20190523</startdate><enddate>20190523</enddate><creator>Sahlol, Nahla Yassin</creator><creator>Mostafa, Marwa Salah</creator><creator>Madkour, Lamiaa Abd El-Fattah</creator><creator>Salama, Dina Metwally</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8906-8938</orcidid><orcidid>https://orcid.org/0000-0002-7849-3904</orcidid></search><sort><creationdate>20190523</creationdate><title>Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity</title><author>Sahlol, Nahla Yassin ; Mostafa, Marwa Salah ; Madkour, Lamiaa Abd El-Fattah ; Salama, Dina Metwally</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-a7591face239cd8e7e3d8a658bf6f0c23857f7f2d35228b61f8ae623abb980c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>B cells</topic><topic>Bioindicators</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahlol, Nahla Yassin</au><au>Mostafa, Marwa Salah</au><au>Madkour, Lamiaa Abd El-Fattah</au><au>Salama, Dina Metwally</au><au>Rich, Benjamin Edward</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-05-23</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>e0217352</spage><epage>e0217352</epage><pages>e0217352-e0217352</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Psoriasis vulgaris is a systemic disorder with an underlying immune dysregulation that predisposes to inflammatory skin lesions. Meanwhile, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against the deleterious effects of uncontrolled inflammation. In this study, we compared the expression levels of TNFAIP3 in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. Additionally, the levels of TNFAIP3 protein in psoriatic skin biopsies were compared to those in normal individuals. Thirty psoriatic patients and 30 healthy participants (control group) were enrolled. The expression levels of TNFAIP3 in blood and skin were measured by quantitative reverse transcription PCR, while the skin levels of TNFAIP3 protein were measured by western blot. Psoriatic patients showed significantly lower expression levels of TNFAIP3 in psoriatic skin and blood (P< 0.001) as well as of TNFAIP3 protein in psoriatic skin (P< 0.001) compared to controls. A significant lower expression of TNFAIP3 and TNFAIP3 protein in psoriatic skin was detected in moderate/severe cases compared to mild cases (P = 0.004 and 0.003 respectively). Moreover, a significant negative correlation was found between TNFAIP3 mRNA in psoriatic tissue and psoriasis area severity index values (rs = -0.382, P-value = 0.037). In conclusion, TNFAIP3 may serve as a predictive and prognostic biomarker in psoriatic patients. Enhancing the expression and/or function of TNFAIP3 in the affected cell type may be a promising therapeutic strategy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31120955</pmid><doi>10.1371/journal.pone.0217352</doi><tpages>e0217352</tpages><orcidid>https://orcid.org/0000-0002-8906-8938</orcidid><orcidid>https://orcid.org/0000-0002-7849-3904</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2019-05, Vol.14 (5), p.e0217352-e0217352 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Aged B cells Bioindicators Biology and Life Sciences Biomarkers Biomarkers - blood Biomarkers - metabolism Blood Care and treatment Case-Control Studies Cytokines Disease Disease Susceptibility EDTA Female Gene expression Genes Genetic aspects Genomes Humans Immunology Inflammation Lesions Leukemia Lymphocytes Male Medicine Medicine and Health Sciences Messenger RNA MicroRNAs Middle Aged Necrosis Pathogenesis Polymerase chain reaction Proteins Psoriasis Psoriasis - genetics Psoriasis - metabolism Psoriasis - pathology Psoriasis vulgaris Reverse Transcriptase Polymerase Chain Reaction Reverse transcription RNA RNA, Messenger - genetics RNA, Messenger - metabolism Skin Skin - metabolism Skin - pathology Skin diseases Tumor necrosis factor Tumor Necrosis Factor alpha-Induced Protein 3 - blood Tumor Necrosis Factor alpha-Induced Protein 3 - genetics Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors Ustekinumab Young Adult |
| title | Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T19%3A34%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20TNFAIP3%20expression%20in%20psoriatic%20skin%20promotes%20disease%20susceptibility%20and%20severity&rft.jtitle=PloS%20one&rft.au=Sahlol,%20Nahla%20Yassin&rft.date=2019-05-23&rft.volume=14&rft.issue=5&rft.spage=e0217352&rft.epage=e0217352&rft.pages=e0217352-e0217352&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0217352&rft_dat=%3Cgale_plos_%3EA586423467%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2229633902&rft_id=info:pmid/31120955&rft_galeid=A586423467&rft_doaj_id=oai_doaj_org_article_1e4f1fe3773a4942877da766152a3597&rfr_iscdi=true |