Voluntary wheel running activates Akt/AMPK/eNOS signaling cascades without improving profound endothelial dysfunction in mice deficient in α-galactosidase A

Fabry disease is caused by loss of activity of the lysosomal hydrolase α-galactosidase A (GLA). Premature life-threatening complications in Fabry patients arise from cardiovascular disease, including stroke and myocardial infarction. Exercise training has been shown to improve endothelial dysfunctio...

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Veröffentlicht in:	PloS one 2019-05, Vol.14 (5), p.e0217214-e0217214
Hauptverfasser:	Kang, Justin J, Treadwell, Taylour A, Bodary, Peter F, Shayman, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine AKT protein alpha-Galactosidase - physiology AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Aorta Atherosclerosis Bioavailability Biology and Life Sciences Cardiomyopathy Cardiovascular disease Cardiovascular diseases Cascades Cerebral infarction Citrate synthase Complications Coronary artery Coronary artery disease Coronary vessels Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzymes Exercise Fabry's disease Fitness training programs Food intake Galactosidase Gastrocnemius muscle Glutathione Heart Heart diseases Hydrolase Intervention Kinases Kinesiology Male Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Muscles Myocardial infarction NAD(P)H oxidase Nitric oxide Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Oxidative Stress Phosphorylation Physical Conditioning, Animal Physical fitness Physical training Physiology Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Pulmonary arteries Research and Analysis Methods Running - physiology Signal Transduction Signaling Superoxide dismutase Training Vascular Diseases - metabolism Vascular Diseases - pathology Wheel running
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