Influence of own mother's milk and different proportions of formula on intestinal microbiota of very preterm newborns
To determine the differences in preterm infants' stool microbiota considering the use of exclusive own mother's milk and formula in different proportions in the first 28 days of life. The study included newborns with GA ≤ 32 weeks divided in 5 group according the feeding regimen: 7 exclusi...
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| creator | Zanella, Adriana Silveira, Rita C Roesch, Luiz F W Corso, Andréa L Dobbler, Priscila T Mai, Volker Procianoy, Renato S |
| description | To determine the differences in preterm infants' stool microbiota considering the use of exclusive own mother's milk and formula in different proportions in the first 28 days of life.
The study included newborns with GA ≤ 32 weeks divided in 5 group according the feeding regimen: 7 exclusive own mother's milk, 8 exclusive preterm formula, 16 mixed feeding with >70% own mother's milk, 16 mixed feeding with >70% preterm formula, and 15 mixed 50% own mother's milk and preterm formula. Exclusion criteria: congenital infections, congenital malformations and newborns of drug addicted mothers. Stools were collected weekly during the first 28 days. Microbial DNA extraction, 16S rRNA amplification and sequencing were performed.
All groups were similar in perinatal and neonatal data. There were significant differences in microbial community among treatments. Approximately 37% of the variation in distance between microbial communities was explained by use of exclusive own mother´s milk only compared to other diets. The diet composed by exclusive own mother´s milk allowed for greater microbial richness (average of 85 OTUs) while diets based on preferably formula, exclusive formula, preferably maternal milk, and mixed of formula and maternal milk presented an average of 9, 29, 23, and 25 OTUs respectively. The mean proportion of the genus Escherichia and Clostridium was always greater in those containing formula than in the those with maternal milk only.
Fecal microbiota in the neonatal period of preterm infants fed with exclusive own mother's milk presented increased richness and differences in microbial composition from those fed with different proportions of formula. |
| doi_str_mv | 10.1371/journal.pone.0217296 |
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The study included newborns with GA ≤ 32 weeks divided in 5 group according the feeding regimen: 7 exclusive own mother's milk, 8 exclusive preterm formula, 16 mixed feeding with >70% own mother's milk, 16 mixed feeding with >70% preterm formula, and 15 mixed 50% own mother's milk and preterm formula. Exclusion criteria: congenital infections, congenital malformations and newborns of drug addicted mothers. Stools were collected weekly during the first 28 days. Microbial DNA extraction, 16S rRNA amplification and sequencing were performed.
All groups were similar in perinatal and neonatal data. There were significant differences in microbial community among treatments. Approximately 37% of the variation in distance between microbial communities was explained by use of exclusive own mother´s milk only compared to other diets. The diet composed by exclusive own mother´s milk allowed for greater microbial richness (average of 85 OTUs) while diets based on preferably formula, exclusive formula, preferably maternal milk, and mixed of formula and maternal milk presented an average of 9, 29, 23, and 25 OTUs respectively. The mean proportion of the genus Escherichia and Clostridium was always greater in those containing formula than in the those with maternal milk only.
Fecal microbiota in the neonatal period of preterm infants fed with exclusive own mother's milk presented increased richness and differences in microbial composition from those fed with different proportions of formula.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0217296</identifier><identifier>PMID: 31107919</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Antibiotics ; Babies ; Biology and Life Sciences ; Birth defects ; Birth weight ; Breast milk ; Breastfeeding & lactation ; Comparative analysis ; Congenital defects ; Deoxyribonucleic acid ; Diet ; DNA ; DNA sequencing ; Drug abusers ; Fecal microflora ; Feeding ; Female ; Food and nutrition ; Gastrointestinal Microbiome - genetics ; Gene sequencing ; Genetic testing ; Health aspects ; Hospitals ; Humans ; Infant Formula ; Infant formulas ; Infant Nutritional Physiological Phenomena ; Infant, Extremely Premature ; Infant, Newborn ; Infants ; Infection ; Influence ; Intestinal microflora ; Intestine ; Medicine and Health Sciences ; Microbial activity ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Milk ; Milk, Human ; Mothers ; Neonates ; Neonatology ; Newborn babies ; Newborn infants ; Pathogens ; People and Places ; Physiological aspects ; Pregnancy ; Premature infants ; RNA ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Systematic review</subject><ispartof>PloS one, 2019-05, Vol.14 (5), p.e0217296-e0217296</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Zanella et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Zanella et al 2019 Zanella et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a42dd21a2f1b2b1f4a53748a7bf9662f3d07018fbf0d7849b979799bb52874ae3</citedby><cites>FETCH-LOGICAL-c692t-a42dd21a2f1b2b1f4a53748a7bf9662f3d07018fbf0d7849b979799bb52874ae3</cites><orcidid>0000-0001-8297-4164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527203/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527203/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31107919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Jensen, Paul</contributor><creatorcontrib>Zanella, Adriana</creatorcontrib><creatorcontrib>Silveira, Rita C</creatorcontrib><creatorcontrib>Roesch, Luiz F W</creatorcontrib><creatorcontrib>Corso, Andréa L</creatorcontrib><creatorcontrib>Dobbler, Priscila T</creatorcontrib><creatorcontrib>Mai, Volker</creatorcontrib><creatorcontrib>Procianoy, Renato S</creatorcontrib><title>Influence of own mother's milk and different proportions of formula on intestinal microbiota of very preterm newborns</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine the differences in preterm infants' stool microbiota considering the use of exclusive own mother's milk and formula in different proportions in the first 28 days of life.
The study included newborns with GA ≤ 32 weeks divided in 5 group according the feeding regimen: 7 exclusive own mother's milk, 8 exclusive preterm formula, 16 mixed feeding with >70% own mother's milk, 16 mixed feeding with >70% preterm formula, and 15 mixed 50% own mother's milk and preterm formula. Exclusion criteria: congenital infections, congenital malformations and newborns of drug addicted mothers. Stools were collected weekly during the first 28 days. Microbial DNA extraction, 16S rRNA amplification and sequencing were performed.
All groups were similar in perinatal and neonatal data. There were significant differences in microbial community among treatments. Approximately 37% of the variation in distance between microbial communities was explained by use of exclusive own mother´s milk only compared to other diets. The diet composed by exclusive own mother´s milk allowed for greater microbial richness (average of 85 OTUs) while diets based on preferably formula, exclusive formula, preferably maternal milk, and mixed of formula and maternal milk presented an average of 9, 29, 23, and 25 OTUs respectively. The mean proportion of the genus Escherichia and Clostridium was always greater in those containing formula than in the those with maternal milk only.
Fecal microbiota in the neonatal period of preterm infants fed with exclusive own mother's milk presented increased richness and differences in microbial composition from those fed with different proportions of formula.</description><subject>Age</subject><subject>Antibiotics</subject><subject>Babies</subject><subject>Biology and Life Sciences</subject><subject>Birth defects</subject><subject>Birth weight</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Comparative analysis</subject><subject>Congenital defects</subject><subject>Deoxyribonucleic acid</subject><subject>Diet</subject><subject>DNA</subject><subject>DNA sequencing</subject><subject>Drug abusers</subject><subject>Fecal microflora</subject><subject>Feeding</subject><subject>Female</subject><subject>Food and nutrition</subject><subject>Gastrointestinal Microbiome - genetics</subject><subject>Gene sequencing</subject><subject>Genetic testing</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant Formula</subject><subject>Infant formulas</subject><subject>Infant Nutritional Physiological Phenomena</subject><subject>Infant, Extremely Premature</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infection</subject><subject>Influence</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Medicine and Health Sciences</subject><subject>Microbial activity</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microorganisms</subject><subject>Milk</subject><subject>Milk, Human</subject><subject>Mothers</subject><subject>Neonates</subject><subject>Neonatology</subject><subject>Newborn babies</subject><subject>Newborn infants</subject><subject>Pathogens</subject><subject>People and Places</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>Premature infants</subject><subject>RNA</subject><subject>RNA, Ribosomal, 16S - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zanella, Adriana</au><au>Silveira, Rita C</au><au>Roesch, Luiz F W</au><au>Corso, Andréa L</au><au>Dobbler, Priscila T</au><au>Mai, Volker</au><au>Procianoy, Renato S</au><au>Jensen, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of own mother's milk and different proportions of formula on intestinal microbiota of very preterm newborns</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-05-20</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>e0217296</spage><epage>e0217296</epage><pages>e0217296-e0217296</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine the differences in preterm infants' stool microbiota considering the use of exclusive own mother's milk and formula in different proportions in the first 28 days of life.
The study included newborns with GA ≤ 32 weeks divided in 5 group according the feeding regimen: 7 exclusive own mother's milk, 8 exclusive preterm formula, 16 mixed feeding with >70% own mother's milk, 16 mixed feeding with >70% preterm formula, and 15 mixed 50% own mother's milk and preterm formula. Exclusion criteria: congenital infections, congenital malformations and newborns of drug addicted mothers. Stools were collected weekly during the first 28 days. Microbial DNA extraction, 16S rRNA amplification and sequencing were performed.
All groups were similar in perinatal and neonatal data. There were significant differences in microbial community among treatments. Approximately 37% of the variation in distance between microbial communities was explained by use of exclusive own mother´s milk only compared to other diets. The diet composed by exclusive own mother´s milk allowed for greater microbial richness (average of 85 OTUs) while diets based on preferably formula, exclusive formula, preferably maternal milk, and mixed of formula and maternal milk presented an average of 9, 29, 23, and 25 OTUs respectively. The mean proportion of the genus Escherichia and Clostridium was always greater in those containing formula than in the those with maternal milk only.
Fecal microbiota in the neonatal period of preterm infants fed with exclusive own mother's milk presented increased richness and differences in microbial composition from those fed with different proportions of formula.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31107919</pmid><doi>10.1371/journal.pone.0217296</doi><tpages>e0217296</tpages><orcidid>https://orcid.org/0000-0001-8297-4164</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-05, Vol.14 (5), p.e0217296-e0217296 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2227830608 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Antibiotics Babies Biology and Life Sciences Birth defects Birth weight Breast milk Breastfeeding & lactation Comparative analysis Congenital defects Deoxyribonucleic acid Diet DNA DNA sequencing Drug abusers Fecal microflora Feeding Female Food and nutrition Gastrointestinal Microbiome - genetics Gene sequencing Genetic testing Health aspects Hospitals Humans Infant Formula Infant formulas Infant Nutritional Physiological Phenomena Infant, Extremely Premature Infant, Newborn Infants Infection Influence Intestinal microflora Intestine Medicine and Health Sciences Microbial activity Microbiota Microbiota (Symbiotic organisms) Microorganisms Milk Milk, Human Mothers Neonates Neonatology Newborn babies Newborn infants Pathogens People and Places Physiological aspects Pregnancy Premature infants RNA RNA, Ribosomal, 16S - genetics rRNA 16S Systematic review |
| title | Influence of own mother's milk and different proportions of formula on intestinal microbiota of very preterm newborns |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T01%3A13%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20own%20mother's%20milk%20and%20different%20proportions%20of%20formula%20on%20intestinal%20microbiota%20of%20very%20preterm%20newborns&rft.jtitle=PloS%20one&rft.au=Zanella,%20Adriana&rft.date=2019-05-20&rft.volume=14&rft.issue=5&rft.spage=e0217296&rft.epage=e0217296&rft.pages=e0217296-e0217296&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0217296&rft_dat=%3Cgale_plos_%3EA586083052%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2227830608&rft_id=info:pmid/31107919&rft_galeid=A586083052&rft_doaj_id=oai_doaj_org_article_acc62b6d96ef440e9923a5aa26d58813&rfr_iscdi=true |