Effects of lifestyle-related factors on ischemic heart disease according to body mass index and fasting blood glucose levels in Korean adults

To investigate the effects of lifestyle-related factors on ischemic heart disease (IHD) according to body mass index (BMI) and fasting blood glucose (FBG) levels among Korean adults. A total of 119,929 men and 89,669 women (from National Sample Cohort version 2.0, National Health Insurance Service)...

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Veröffentlicht in:PloS one 2019-05, Vol.14 (5), p.e0216534-e0216534
Hauptverfasser: Shin, Jiae, Ham, Dongwoo, Shin, Sangah, Choi, Seul Ki, Paik, Hee-Young, Joung, Hyojee
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creator Shin, Jiae
Ham, Dongwoo
Shin, Sangah
Choi, Seul Ki
Paik, Hee-Young
Joung, Hyojee
description To investigate the effects of lifestyle-related factors on ischemic heart disease (IHD) according to body mass index (BMI) and fasting blood glucose (FBG) levels among Korean adults. A total of 119,929 men and 89,669 women (from National Sample Cohort version 2.0, National Health Insurance Service) aged ≥20 years who were examined during 2003-2006 and had no preexisting type 2 diabetes or circulatory diseases were followed until December 2015 to confirm IHD incident cases. Data on lifestyle-related factors (BMI, FBG, diet, smoking, alcohol consumption, and physical activity) were collected at baseline. Lifestyle-related risk factors were defined as mainly vegetable/mainly meat diet, former/current smoking, alcohol consumption ≥3 times/week, and no physical activity. Associations between these factors and IHD were examined using Cox proportional hazards regression models. High BMI (≥25 kg/m2), high FBG (≥100 mg/dL), mainly meat diet, and former/current smoking were associated with increased risk for IHD. Alcohol consumption ≤twice/week and physical activity ≤twice/week were associated with lower risk of IHD. With increased lifestyle-related risk factors, the risk of IHD also increased in women (hazard ratio [HR] = 3.21, 95% confidence interval [CI] 2.18-4.73) and men (HR = 1.66, 95% CI 1.48-1.85). This increase was larger in women, with a significant sex interaction (p = 0.0001). Significant interactions between BMI and alcohol consumption (p = 0.0002) and between BMI and physical activity (p = 0.0063) were observed. Interactions were seen between FBG level and meal type in both BMI
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A total of 119,929 men and 89,669 women (from National Sample Cohort version 2.0, National Health Insurance Service) aged ≥20 years who were examined during 2003-2006 and had no preexisting type 2 diabetes or circulatory diseases were followed until December 2015 to confirm IHD incident cases. Data on lifestyle-related factors (BMI, FBG, diet, smoking, alcohol consumption, and physical activity) were collected at baseline. Lifestyle-related risk factors were defined as mainly vegetable/mainly meat diet, former/current smoking, alcohol consumption ≥3 times/week, and no physical activity. Associations between these factors and IHD were examined using Cox proportional hazards regression models. High BMI (≥25 kg/m2), high FBG (≥100 mg/dL), mainly meat diet, and former/current smoking were associated with increased risk for IHD. Alcohol consumption ≤twice/week and physical activity ≤twice/week were associated with lower risk of IHD. With increased lifestyle-related risk factors, the risk of IHD also increased in women (hazard ratio [HR] = 3.21, 95% confidence interval [CI] 2.18-4.73) and men (HR = 1.66, 95% CI 1.48-1.85). This increase was larger in women, with a significant sex interaction (p = 0.0001). Significant interactions between BMI and alcohol consumption (p = 0.0002) and between BMI and physical activity (p = 0.0063) were observed. Interactions were seen between FBG level and meal type in both BMI&lt;25 kg/m2 (p = 0.0106) and BMI≥25 kg/m2 (p = 0.0281) and between FBG level and alcohol consumption in BMI ≥25 kg/m2 (p = 0.0118). The impact of lifestyle-related factors on IHD was more pronounced in women than in men and may be modified by BMI and FBG level among Korean adults. This might be taken into account when planning individual interventions to reduce IHD risk.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0216534</identifier><identifier>PMID: 31091295</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Age Distribution ; Alcohol use ; Alcoholic beverages ; Analysis ; Biology and Life Sciences ; Blood ; Blood glucose ; Blood Glucose - analysis ; Body mass ; Body Mass Index ; Body size ; Cardiovascular disease ; Cardiovascular diseases ; Confidence intervals ; Consumption ; Coronary artery disease ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diet ; Drinking (Alcoholic beverages) ; Exercise ; Fasting ; Female ; Glucose ; Hazards ; Health aspects ; Health risk assessment ; Health risks ; Healthy Lifestyle ; Heart diseases ; Humans ; Incidence ; Insurance ; Ischemia ; Levels ; Lifestyles ; Male ; Meat ; Medicine and Health Sciences ; Men ; Middle Aged ; Mortality ; Myocardial ischemia ; Myocardial Ischemia - epidemiology ; National health insurance ; Patient outcomes ; Physical activity ; Physical fitness ; Regression analysis ; Regression models ; Republic of Korea ; Risk analysis ; Risk Assessment ; Risk factors ; Smoking ; Statistical analysis ; Systematic review ; Type 2 diabetes ; Women ; Young Adult</subject><ispartof>PloS one, 2019-05, Vol.14 (5), p.e0216534-e0216534</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Shin et al. 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A total of 119,929 men and 89,669 women (from National Sample Cohort version 2.0, National Health Insurance Service) aged ≥20 years who were examined during 2003-2006 and had no preexisting type 2 diabetes or circulatory diseases were followed until December 2015 to confirm IHD incident cases. Data on lifestyle-related factors (BMI, FBG, diet, smoking, alcohol consumption, and physical activity) were collected at baseline. Lifestyle-related risk factors were defined as mainly vegetable/mainly meat diet, former/current smoking, alcohol consumption ≥3 times/week, and no physical activity. Associations between these factors and IHD were examined using Cox proportional hazards regression models. High BMI (≥25 kg/m2), high FBG (≥100 mg/dL), mainly meat diet, and former/current smoking were associated with increased risk for IHD. Alcohol consumption ≤twice/week and physical activity ≤twice/week were associated with lower risk of IHD. 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This might be taken into account when planning individual interventions to reduce IHD risk.</description><subject>Adult</subject><subject>Adults</subject><subject>Age Distribution</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Blood Glucose - analysis</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Confidence intervals</subject><subject>Consumption</subject><subject>Coronary artery disease</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diet</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Exercise</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose</subject><subject>Hazards</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Healthy Lifestyle</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Insurance</subject><subject>Ischemia</subject><subject>Levels</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Meat</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial ischemia</subject><subject>Myocardial Ischemia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Jiae</au><au>Ham, Dongwoo</au><au>Shin, Sangah</au><au>Choi, Seul Ki</au><au>Paik, Hee-Young</au><au>Joung, Hyojee</au><au>Fürnsinn, Clemens</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of lifestyle-related factors on ischemic heart disease according to body mass index and fasting blood glucose levels in Korean adults</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-05-15</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>e0216534</spage><epage>e0216534</epage><pages>e0216534-e0216534</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To investigate the effects of lifestyle-related factors on ischemic heart disease (IHD) according to body mass index (BMI) and fasting blood glucose (FBG) levels among Korean adults. A total of 119,929 men and 89,669 women (from National Sample Cohort version 2.0, National Health Insurance Service) aged ≥20 years who were examined during 2003-2006 and had no preexisting type 2 diabetes or circulatory diseases were followed until December 2015 to confirm IHD incident cases. Data on lifestyle-related factors (BMI, FBG, diet, smoking, alcohol consumption, and physical activity) were collected at baseline. Lifestyle-related risk factors were defined as mainly vegetable/mainly meat diet, former/current smoking, alcohol consumption ≥3 times/week, and no physical activity. Associations between these factors and IHD were examined using Cox proportional hazards regression models. High BMI (≥25 kg/m2), high FBG (≥100 mg/dL), mainly meat diet, and former/current smoking were associated with increased risk for IHD. Alcohol consumption ≤twice/week and physical activity ≤twice/week were associated with lower risk of IHD. With increased lifestyle-related risk factors, the risk of IHD also increased in women (hazard ratio [HR] = 3.21, 95% confidence interval [CI] 2.18-4.73) and men (HR = 1.66, 95% CI 1.48-1.85). This increase was larger in women, with a significant sex interaction (p = 0.0001). Significant interactions between BMI and alcohol consumption (p = 0.0002) and between BMI and physical activity (p = 0.0063) were observed. Interactions were seen between FBG level and meal type in both BMI&lt;25 kg/m2 (p = 0.0106) and BMI≥25 kg/m2 (p = 0.0281) and between FBG level and alcohol consumption in BMI ≥25 kg/m2 (p = 0.0118). The impact of lifestyle-related factors on IHD was more pronounced in women than in men and may be modified by BMI and FBG level among Korean adults. This might be taken into account when planning individual interventions to reduce IHD risk.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31091295</pmid><doi>10.1371/journal.pone.0216534</doi><tpages>e0216534</tpages><orcidid>https://orcid.org/0000-0003-2433-2280</orcidid><orcidid>https://orcid.org/0000-0003-1182-7786</orcidid><orcidid>https://orcid.org/0000-0001-6693-0268</orcidid><oa>free_for_read</oa></addata></record>
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source MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry
subjects Adult
Adults
Age Distribution
Alcohol use
Alcoholic beverages
Analysis
Biology and Life Sciences
Blood
Blood glucose
Blood Glucose - analysis
Body mass
Body Mass Index
Body size
Cardiovascular disease
Cardiovascular diseases
Confidence intervals
Consumption
Coronary artery disease
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diet
Drinking (Alcoholic beverages)
Exercise
Fasting
Female
Glucose
Hazards
Health aspects
Health risk assessment
Health risks
Healthy Lifestyle
Heart diseases
Humans
Incidence
Insurance
Ischemia
Levels
Lifestyles
Male
Meat
Medicine and Health Sciences
Men
Middle Aged
Mortality
Myocardial ischemia
Myocardial Ischemia - epidemiology
National health insurance
Patient outcomes
Physical activity
Physical fitness
Regression analysis
Regression models
Republic of Korea
Risk analysis
Risk Assessment
Risk factors
Smoking
Statistical analysis
Systematic review
Type 2 diabetes
Women
Young Adult
title Effects of lifestyle-related factors on ischemic heart disease according to body mass index and fasting blood glucose levels in Korean adults
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