Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis
Delayed wound healing and reduced barrier function with an increased risk of cancer are characteristics of aged skin and one possible mechanism is misregulation or dysfunction of epidermal stem cells during aging. Recent studies have identified heterogeneous stem cell populations within the mouse in...
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| creator | Changarathil, Gopakumar Ramirez, Karina Isoda, Hiroko Sada, Aiko Yanagisawa, Hiromi |
| description | Delayed wound healing and reduced barrier function with an increased risk of cancer are characteristics of aged skin and one possible mechanism is misregulation or dysfunction of epidermal stem cells during aging. Recent studies have identified heterogeneous stem cell populations within the mouse interfollicular epidermis that are defined by territorial distribution and cell division frequency; however, it is unknown whether the individual stem cell populations undergo distinct aging processes. Here we provide comprehensive characterization of age-related changes in the mouse epidermis within the specific territories of slow-cycling and fast-dividing stem cells using old wild-type, senescence-accelerated mouse prone 1 (SAMP1) and SAMP8 mice. During aging, the epidermis exhibits structural changes such as irregular micro-undulations and overall thinning of the tissue. We also find that, in the old epidermis, proliferation is preferentially decreased in the region where fast-dividing stem cells reside whereas the lineage differentiation marker appears to be more affected in the slow-cycling stem cell region. Furthermore, SAMP8, but not SAMP1, exhibits precocious aging similar to that of aged wild-type mice, suggesting a potential use of this model for aging study of the epidermis and its stem cells. Taken together, our study reveals distinct aging processes governing the two epidermal stem cell populations and suggests a potential mechanism in differential responses of compartmentalized stem cells and their niches to aging. |
| doi_str_mv | 10.1371/journal.pone.0215908 |
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Recent studies have identified heterogeneous stem cell populations within the mouse interfollicular epidermis that are defined by territorial distribution and cell division frequency; however, it is unknown whether the individual stem cell populations undergo distinct aging processes. Here we provide comprehensive characterization of age-related changes in the mouse epidermis within the specific territories of slow-cycling and fast-dividing stem cells using old wild-type, senescence-accelerated mouse prone 1 (SAMP1) and SAMP8 mice. During aging, the epidermis exhibits structural changes such as irregular micro-undulations and overall thinning of the tissue. We also find that, in the old epidermis, proliferation is preferentially decreased in the region where fast-dividing stem cells reside whereas the lineage differentiation marker appears to be more affected in the slow-cycling stem cell region. Furthermore, SAMP8, but not SAMP1, exhibits precocious aging similar to that of aged wild-type mice, suggesting a potential use of this model for aging study of the epidermis and its stem cells. Taken together, our study reveals distinct aging processes governing the two epidermal stem cell populations and suggests a potential mechanism in differential responses of compartmentalized stem cells and their niches to aging.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0215908</identifier><identifier>PMID: 31091266</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aging ; Aging (Biology) ; Animals ; Apoptosis ; Biology and Life Sciences ; Cancer prevention ; Cell Differentiation ; Cell Division ; Cell Proliferation ; Cellular Senescence ; Cycles ; Epidermis ; Epidermis - metabolism ; Fibroblasts ; Gene expression ; Genetic aspects ; Genomics ; Health aspects ; Health risks ; Laboratory animals ; Life sciences ; Medicine and Health Sciences ; Melatonin ; Methods ; Mice ; Morphology ; Mutation ; Physiological aspects ; Populations ; Research and Analysis Methods ; Senescence ; Skin ; Skin care ; Species Specificity ; Stem cell transplantation ; Stem cells ; Stem Cells - cytology ; Studies ; Wound care ; Wound healing</subject><ispartof>PloS one, 2019-05, Vol.14 (5), p.e0215908-e0215908</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Changarathil et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Changarathil et al 2019 Changarathil et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c802t-2369e4c916026990f76f637eec255be38c19414c34a2796d3e0a897b3c6ec1113</citedby><cites>FETCH-LOGICAL-c802t-2369e4c916026990f76f637eec255be38c19414c34a2796d3e0a897b3c6ec1113</cites><orcidid>0000-0002-0984-4280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519801/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519801/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31091266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kanungo, Jyotshna</contributor><creatorcontrib>Changarathil, Gopakumar</creatorcontrib><creatorcontrib>Ramirez, Karina</creatorcontrib><creatorcontrib>Isoda, Hiroko</creatorcontrib><creatorcontrib>Sada, Aiko</creatorcontrib><creatorcontrib>Yanagisawa, Hiromi</creatorcontrib><title>Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Delayed wound healing and reduced barrier function with an increased risk of cancer are characteristics of aged skin and one possible mechanism is misregulation or dysfunction of epidermal stem cells during aging. Recent studies have identified heterogeneous stem cell populations within the mouse interfollicular epidermis that are defined by territorial distribution and cell division frequency; however, it is unknown whether the individual stem cell populations undergo distinct aging processes. Here we provide comprehensive characterization of age-related changes in the mouse epidermis within the specific territories of slow-cycling and fast-dividing stem cells using old wild-type, senescence-accelerated mouse prone 1 (SAMP1) and SAMP8 mice. During aging, the epidermis exhibits structural changes such as irregular micro-undulations and overall thinning of the tissue. We also find that, in the old epidermis, proliferation is preferentially decreased in the region where fast-dividing stem cells reside whereas the lineage differentiation marker appears to be more affected in the slow-cycling stem cell region. Furthermore, SAMP8, but not SAMP1, exhibits precocious aging similar to that of aged wild-type mice, suggesting a potential use of this model for aging study of the epidermis and its stem cells. Taken together, our study reveals distinct aging processes governing the two epidermal stem cell populations and suggests a potential mechanism in differential responses of compartmentalized stem cells and their niches to aging.</description><subject>Age</subject><subject>Aging</subject><subject>Aging (Biology)</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biology and Life Sciences</subject><subject>Cancer prevention</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cell Proliferation</subject><subject>Cellular Senescence</subject><subject>Cycles</subject><subject>Epidermis</subject><subject>Epidermis - metabolism</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Laboratory animals</subject><subject>Life sciences</subject><subject>Medicine and Health Sciences</subject><subject>Melatonin</subject><subject>Methods</subject><subject>Mice</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Physiological aspects</subject><subject>Populations</subject><subject>Research and Analysis Methods</subject><subject>Senescence</subject><subject>Skin</subject><subject>Skin care</subject><subject>Species Specificity</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stem Cells - 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Recent studies have identified heterogeneous stem cell populations within the mouse interfollicular epidermis that are defined by territorial distribution and cell division frequency; however, it is unknown whether the individual stem cell populations undergo distinct aging processes. Here we provide comprehensive characterization of age-related changes in the mouse epidermis within the specific territories of slow-cycling and fast-dividing stem cells using old wild-type, senescence-accelerated mouse prone 1 (SAMP1) and SAMP8 mice. During aging, the epidermis exhibits structural changes such as irregular micro-undulations and overall thinning of the tissue. We also find that, in the old epidermis, proliferation is preferentially decreased in the region where fast-dividing stem cells reside whereas the lineage differentiation marker appears to be more affected in the slow-cycling stem cell region. Furthermore, SAMP8, but not SAMP1, exhibits precocious aging similar to that of aged wild-type mice, suggesting a potential use of this model for aging study of the epidermis and its stem cells. Taken together, our study reveals distinct aging processes governing the two epidermal stem cell populations and suggests a potential mechanism in differential responses of compartmentalized stem cells and their niches to aging.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31091266</pmid><doi>10.1371/journal.pone.0215908</doi><tpages>e0215908</tpages><orcidid>https://orcid.org/0000-0002-0984-4280</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Aging Aging (Biology) Animals Apoptosis Biology and Life Sciences Cancer prevention Cell Differentiation Cell Division Cell Proliferation Cellular Senescence Cycles Epidermis Epidermis - metabolism Fibroblasts Gene expression Genetic aspects Genomics Health aspects Health risks Laboratory animals Life sciences Medicine and Health Sciences Melatonin Methods Mice Morphology Mutation Physiological aspects Populations Research and Analysis Methods Senescence Skin Skin care Species Specificity Stem cell transplantation Stem cells Stem Cells - cytology Studies Wound care Wound healing |
| title | Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis |
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