The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants of the best...

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Veröffentlicht in:	PloS one 2019-05, Vol.14 (5), p.e0215696
Hauptverfasser:	Ahmed, Syed Moiz, Ramani, Priya Dharshana, Wong, Stephen Qi Rong, Zhao, Xiaodan, Ivanyi-Nagy, Roland, Leong, Tang Choong, Chua, Clarinda, Li, Zhizhong, Hentze, Hannes, Tan, Iain BeeHuat, Yan, Jie, DasGupta, Ramanuj, Dröge, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic agents Bioinformatics Cancer Cancer cells Cancer genetics Cancer prevention Cancer treatment Cell cycle Cell Line, Tumor Chemotherapy Chromatin Chromatin - metabolism Chromosomal proteins Chromosomes Colorectal cancer Control stability Coordination compounds Cytotoxicity Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage DNA Replication - genetics DNA topoisomerase DNA Topoisomerases, Type I - metabolism Drug interactions Enzymes Female Gene Expression Regulation, Neoplastic Genomes Genomics Genotoxicity HMGA2 Protein - genetics HMGA2 Protein - metabolism Humans Hydroxyurea Irinotecan Laboratories Male Patient outcomes Physiological aspects Poisoning Poisons Properties Protein structure Proteins Replication Replication forks Substrates Supercoiling Telomerase Telomere - genetics Telomeres Topology Translocation Xenografts Xenotransplantation
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