Differences in plasma levels of long chain and very long chain ceramides between African Americans and whites: An observational study
Population-wide reductions in cardiovascular disease (CVD) have not been equally shared in the African American community due to a higher burden of CVD risk factors such as metabolic disorders and obesity. Differential concentrations of sphingolipids such as ceramide, sphingosine, and sphingosine 1-...
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| Veröffentlicht in: | PloS one 2019-05, Vol.14 (5), p.e0216213 |
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| creator | Buie, Joy N Jones Hammad, Samar M Nietert, Paul J Magwood, Gayenell Adams, Robert J Bonilha, Leonardo Sims-Robinson, Catrina |
| description | Population-wide reductions in cardiovascular disease (CVD) have not been equally shared in the African American community due to a higher burden of CVD risk factors such as metabolic disorders and obesity. Differential concentrations of sphingolipids such as ceramide, sphingosine, and sphingosine 1-phosphate (S1P) has been associated with the development of CVD, metabolic disorders (MetD), and obesity. Whether African Americans have disparate expression levels of sphingolipids that explain higher burdens of CVD remains unknown.
A cross sectional analysis of plasma concentrations of ceramides, sphingosine, and S1P were measured from 8 whites and 7 African Americans without metabolic disorders and 7 whites and 8 African Americans with metabolic disorders using high performance liquid chromatography/tandem mass spectrometry methodology (HPLC/MS-MS). Subjects were stratified by both race and metabolic status. Subjects with one or more of the following physician confirmed diagnosis: diabetes, hypertension, hypercholesterolemia, or dyslipidemia were classified as having metabolic disease (MetD). Data was analyzed using a Two-Way ANOVA and Tukey's post hoc test.
Total ceramide levels were increased in African Americans compared to African Americans with MetD. Ceramide C16 levels were higher in whites with MetD compared to African Americans with MetD (p |
| doi_str_mv | 10.1371/journal.pone.0216213 |
| format | Article |
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A cross sectional analysis of plasma concentrations of ceramides, sphingosine, and S1P were measured from 8 whites and 7 African Americans without metabolic disorders and 7 whites and 8 African Americans with metabolic disorders using high performance liquid chromatography/tandem mass spectrometry methodology (HPLC/MS-MS). Subjects were stratified by both race and metabolic status. Subjects with one or more of the following physician confirmed diagnosis: diabetes, hypertension, hypercholesterolemia, or dyslipidemia were classified as having metabolic disease (MetD). Data was analyzed using a Two-Way ANOVA and Tukey's post hoc test.
Total ceramide levels were increased in African Americans compared to African Americans with MetD. Ceramide C16 levels were higher in whites with MetD compared to African Americans with MetD (p<0.05). Ceramide C20 levels were higher in whites with MetD compared to whites. Ceramide C20 levels were higher in African Americans compared to African Americans with MetD. Furthermore, whites with MetD had higher levels of C20 compared to African Americans with MetD (p<0.0001). Ceramide C24:0 and C24:1 in African Americans was higher compared to African Americans with MetD (p<0.05). The plasma concentration of Sph-1P ceramide was higher in African Americans vs whites (p = 0.01). Lastly, ceramide C20 negatively correlated with hemoglobin A1c (HbA1c) levels in our study cohort.
Plasma ceramide concentration patterns are distinct in African Americans with MetD. Further research with larger samples sizes are needed to confirm these findings and to understand whether racial disparities in sphingolipid concentrations have potential therapeutic implications for CVD-related health outcomes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0216213</identifier><identifier>PMID: 31067249</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; African Americans ; Aged ; Biology and Life Sciences ; Black or African American - statistics & numerical data ; Cardiovascular disease ; Cardiovascular diseases ; Ceramide ; Ceramides ; Ceramides - blood ; Chains ; Chromatography ; Chromatography, High Pressure Liquid ; Comparative analysis ; Coronary vessels ; Cross-Sectional Studies ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - blood ; Disorders ; Dyslipidemia ; Dyslipidemias - blood ; Fasting ; Female ; Gas Chromatography-Mass Spectrometry ; Health aspects ; Health risk assessment ; Heart ; Hemoglobin ; High performance liquid chromatography ; Humans ; Hypercholesterolemia ; Hypercholesterolemia - blood ; Hypertension ; Hypertension - blood ; Insulin resistance ; Liquid chromatography ; Lysophospholipids - blood ; Male ; Mass spectrometry ; Mass spectroscopy ; Medicine and Health Sciences ; Metabolic disorders ; Metabolism ; Middle Aged ; Minority & ethnic groups ; Neurology ; Obesity ; Observational studies ; People and places ; Plasma levels ; Population studies ; Risk analysis ; Risk Factors ; Sphingolipids ; Sphingosine - analogs & derivatives ; Sphingosine - blood ; Sphingosine 1-phosphate ; Stroke ; Studies ; Variance analysis ; White People - statistics & numerical data ; Whites</subject><ispartof>PloS one, 2019-05, Vol.14 (5), p.e0216213</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Buie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Buie et al 2019 Buie et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c2f5e6bbdc11560dc910431b2ca1920253c50eab113a7a0d0a000c7372c0bff43</citedby><cites>FETCH-LOGICAL-c692t-c2f5e6bbdc11560dc910431b2ca1920253c50eab113a7a0d0a000c7372c0bff43</cites><orcidid>0000-0003-4776-5839</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505935/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505935/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31067249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Brown, Lindsay</contributor><creatorcontrib>Buie, Joy N Jones</creatorcontrib><creatorcontrib>Hammad, Samar M</creatorcontrib><creatorcontrib>Nietert, Paul J</creatorcontrib><creatorcontrib>Magwood, Gayenell</creatorcontrib><creatorcontrib>Adams, Robert J</creatorcontrib><creatorcontrib>Bonilha, Leonardo</creatorcontrib><creatorcontrib>Sims-Robinson, Catrina</creatorcontrib><title>Differences in plasma levels of long chain and very long chain ceramides between African Americans and whites: An observational study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Population-wide reductions in cardiovascular disease (CVD) have not been equally shared in the African American community due to a higher burden of CVD risk factors such as metabolic disorders and obesity. Differential concentrations of sphingolipids such as ceramide, sphingosine, and sphingosine 1-phosphate (S1P) has been associated with the development of CVD, metabolic disorders (MetD), and obesity. Whether African Americans have disparate expression levels of sphingolipids that explain higher burdens of CVD remains unknown.
A cross sectional analysis of plasma concentrations of ceramides, sphingosine, and S1P were measured from 8 whites and 7 African Americans without metabolic disorders and 7 whites and 8 African Americans with metabolic disorders using high performance liquid chromatography/tandem mass spectrometry methodology (HPLC/MS-MS). Subjects were stratified by both race and metabolic status. Subjects with one or more of the following physician confirmed diagnosis: diabetes, hypertension, hypercholesterolemia, or dyslipidemia were classified as having metabolic disease (MetD). Data was analyzed using a Two-Way ANOVA and Tukey's post hoc test.
Total ceramide levels were increased in African Americans compared to African Americans with MetD. Ceramide C16 levels were higher in whites with MetD compared to African Americans with MetD (p<0.05). Ceramide C20 levels were higher in whites with MetD compared to whites. Ceramide C20 levels were higher in African Americans compared to African Americans with MetD. Furthermore, whites with MetD had higher levels of C20 compared to African Americans with MetD (p<0.0001). Ceramide C24:0 and C24:1 in African Americans was higher compared to African Americans with MetD (p<0.05). The plasma concentration of Sph-1P ceramide was higher in African Americans vs whites (p = 0.01). Lastly, ceramide C20 negatively correlated with hemoglobin A1c (HbA1c) levels in our study cohort.
Plasma ceramide concentration patterns are distinct in African Americans with MetD. Further research with larger samples sizes are needed to confirm these findings and to understand whether racial disparities in sphingolipid concentrations have potential therapeutic implications for CVD-related health outcomes.</description><subject>Adult</subject><subject>African Americans</subject><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Black or African American - statistics & numerical data</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Ceramide</subject><subject>Ceramides</subject><subject>Ceramides - blood</subject><subject>Chains</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Comparative analysis</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Disorders</subject><subject>Dyslipidemia</subject><subject>Dyslipidemias - blood</subject><subject>Fasting</subject><subject>Female</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Hemoglobin</subject><subject>High performance liquid chromatography</subject><subject>Humans</subject><subject>Hypercholesterolemia</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Insulin resistance</subject><subject>Liquid chromatography</subject><subject>Lysophospholipids - blood</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Neurology</subject><subject>Obesity</subject><subject>Observational studies</subject><subject>People and places</subject><subject>Plasma levels</subject><subject>Population studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Sphingolipids</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - blood</subject><subject>Sphingosine 1-phosphate</subject><subject>Stroke</subject><subject>Studies</subject><subject>Variance analysis</subject><subject>White People - statistics & numerical data</subject><subject>Whites</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padK0b1BaQ6G0F7vVwcdeFJb0tBAI9HQrxvJoV0G2NpK96T5A37vyrhPWJRdFFxKj7_9HGmmi6Dklc8pz-u7K9q4FM9_YFueE0YxR_iA6pSVns4wR_vBofRI98f6KkJQXWfY4OuGUZDlLytPoz0etFDpsJfpYt_HGgG8gNrhF42OrYmPbVSzXEPagreMtut1xTKKDRtdBXGF3g9jGC-W0hDA3uF_4ve5mrTv07-NFG9vKo9tCp204fuy7vt49jR4pMB6fjfNZ9PPzpx_nX2cXl1-W54uLmcxK1s0kUylmVVVLStOM1LKkJOG0YhJoyQhLuUwJQkUphxxITYAQInOeM0kqpRJ-Fr08-G6M9WKsoBeMMVpwnuYDsTwQtYUrsXG6AbcTFrTYB6xbCXCdlgYF1LxQStUVKaokz3NgKq9IzUlOs1JhEbw-jNn6qsFaYts5MBPT6U6r12JltyJLSVryNBi8GQ2cve7Rd6LRXqIx0KLth3NzWpRllpGAvvoHvf92I7WCcAHdKhvyysFULNIiKQjhe6_5PVQYNTZahu-mdIhPBG8ngsB0-LtbQe-9WH7_9v_s5a8p-_qIXSOYbu2t6Yev46dgcgCls947VHdFpkQM3XJbDTF0ixi7JcheHD_Qnei2PfhfSiAQYQ</recordid><startdate>20190508</startdate><enddate>20190508</enddate><creator>Buie, Joy N Jones</creator><creator>Hammad, Samar M</creator><creator>Nietert, Paul J</creator><creator>Magwood, Gayenell</creator><creator>Adams, Robert J</creator><creator>Bonilha, Leonardo</creator><creator>Sims-Robinson, Catrina</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4776-5839</orcidid></search><sort><creationdate>20190508</creationdate><title>Differences in plasma levels of long chain and very long chain ceramides between African Americans and whites: An observational study</title><author>Buie, Joy N Jones ; Hammad, Samar M ; Nietert, Paul J ; Magwood, Gayenell ; Adams, Robert J ; Bonilha, Leonardo ; Sims-Robinson, Catrina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-c2f5e6bbdc11560dc910431b2ca1920253c50eab113a7a0d0a000c7372c0bff43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Black or African American - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buie, Joy N Jones</au><au>Hammad, Samar M</au><au>Nietert, Paul J</au><au>Magwood, Gayenell</au><au>Adams, Robert J</au><au>Bonilha, Leonardo</au><au>Sims-Robinson, Catrina</au><au>Brown, Lindsay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in plasma levels of long chain and very long chain ceramides between African Americans and whites: An observational study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-05-08</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>e0216213</spage><pages>e0216213-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Population-wide reductions in cardiovascular disease (CVD) have not been equally shared in the African American community due to a higher burden of CVD risk factors such as metabolic disorders and obesity. Differential concentrations of sphingolipids such as ceramide, sphingosine, and sphingosine 1-phosphate (S1P) has been associated with the development of CVD, metabolic disorders (MetD), and obesity. Whether African Americans have disparate expression levels of sphingolipids that explain higher burdens of CVD remains unknown.
A cross sectional analysis of plasma concentrations of ceramides, sphingosine, and S1P were measured from 8 whites and 7 African Americans without metabolic disorders and 7 whites and 8 African Americans with metabolic disorders using high performance liquid chromatography/tandem mass spectrometry methodology (HPLC/MS-MS). Subjects were stratified by both race and metabolic status. Subjects with one or more of the following physician confirmed diagnosis: diabetes, hypertension, hypercholesterolemia, or dyslipidemia were classified as having metabolic disease (MetD). Data was analyzed using a Two-Way ANOVA and Tukey's post hoc test.
Total ceramide levels were increased in African Americans compared to African Americans with MetD. Ceramide C16 levels were higher in whites with MetD compared to African Americans with MetD (p<0.05). Ceramide C20 levels were higher in whites with MetD compared to whites. Ceramide C20 levels were higher in African Americans compared to African Americans with MetD. Furthermore, whites with MetD had higher levels of C20 compared to African Americans with MetD (p<0.0001). Ceramide C24:0 and C24:1 in African Americans was higher compared to African Americans with MetD (p<0.05). The plasma concentration of Sph-1P ceramide was higher in African Americans vs whites (p = 0.01). Lastly, ceramide C20 negatively correlated with hemoglobin A1c (HbA1c) levels in our study cohort.
Plasma ceramide concentration patterns are distinct in African Americans with MetD. Further research with larger samples sizes are needed to confirm these findings and to understand whether racial disparities in sphingolipid concentrations have potential therapeutic implications for CVD-related health outcomes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31067249</pmid><doi>10.1371/journal.pone.0216213</doi><tpages>e0216213</tpages><orcidid>https://orcid.org/0000-0003-4776-5839</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-05, Vol.14 (5), p.e0216213 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2221833574 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Adult African Americans Aged Biology and Life Sciences Black or African American - statistics & numerical data Cardiovascular disease Cardiovascular diseases Ceramide Ceramides Ceramides - blood Chains Chromatography Chromatography, High Pressure Liquid Comparative analysis Coronary vessels Cross-Sectional Studies Development and progression Diabetes Diabetes mellitus Diabetes Mellitus - blood Disorders Dyslipidemia Dyslipidemias - blood Fasting Female Gas Chromatography-Mass Spectrometry Health aspects Health risk assessment Heart Hemoglobin High performance liquid chromatography Humans Hypercholesterolemia Hypercholesterolemia - blood Hypertension Hypertension - blood Insulin resistance Liquid chromatography Lysophospholipids - blood Male Mass spectrometry Mass spectroscopy Medicine and Health Sciences Metabolic disorders Metabolism Middle Aged Minority & ethnic groups Neurology Obesity Observational studies People and places Plasma levels Population studies Risk analysis Risk Factors Sphingolipids Sphingosine - analogs & derivatives Sphingosine - blood Sphingosine 1-phosphate Stroke Studies Variance analysis White People - statistics & numerical data Whites |
| title | Differences in plasma levels of long chain and very long chain ceramides between African Americans and whites: An observational study |
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