Plasma protein thiolation index (PTI) as a potential biomarker for left ventricular hypertrophy in humans
Left ventricular hypertrophy (LVH) has been associated with oxidative stress, although not with the protein thiolation index (PTI). This study explored the potential use of PTI as a biomarker of oxidative stress in patients with LVH. We recruited 70 consecutive patients (n = 35 LVH and n = 35 non-LV...
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| Veröffentlicht in: | PloS one 2019-05, Vol.14 (5), p.e0216359-e0216359 |
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| creator | Quintana-Villamandos, Begoña González Del Pozo, Irene Pazó-Sayós, Laia Bellón, Jose María Pedraz-Prieto, Álvaro Pinto, Ángel G Delgado-Baeza, Emilio |
| description | Left ventricular hypertrophy (LVH) has been associated with oxidative stress, although not with the protein thiolation index (PTI). This study explored the potential use of PTI as a biomarker of oxidative stress in patients with LVH.
We recruited 70 consecutive patients (n = 35 LVH and n = 35 non-LVH) based on an echocardiography study in our institution (left ventricular mass indexed to body surface area). Plasma levels of both S-thiolated protein and total thiols were measured as biomarkers of oxidative stress by spectrophotometry, and PTI was calculated as the molar ratio between S-thiolated proteins and the total thiol concentration.
Values for plasma S-thiolated proteins were higher in patients with LVH than in the control group (P = 0.01). There were no differences in total thiols between the LVH group and the control group. Finally, PTI was higher in patients with LVH than in the control group (P = 0.001). The area under the ROC curve was 0.75 (95% CI, 0.63-0.86; P |
| doi_str_mv | 10.1371/journal.pone.0216359 |
| format | Article |
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We recruited 70 consecutive patients (n = 35 LVH and n = 35 non-LVH) based on an echocardiography study in our institution (left ventricular mass indexed to body surface area). Plasma levels of both S-thiolated protein and total thiols were measured as biomarkers of oxidative stress by spectrophotometry, and PTI was calculated as the molar ratio between S-thiolated proteins and the total thiol concentration.
Values for plasma S-thiolated proteins were higher in patients with LVH than in the control group (P = 0.01). There were no differences in total thiols between the LVH group and the control group. Finally, PTI was higher in patients with LVH than in the control group (P = 0.001). The area under the ROC curve was 0.75 (95% CI, 0.63-0.86; P<0.001), sensitivity was 70.6%, and specificity was 68.6%, thus suggesting that PTI could be used to screen for LVH. A multivariable logistic regression model showed a positive association (P = 0.02) between PTI and LVH (OR = 1.24 [95% CI, 1.03-1.49]) independently of gender (OR = 3.39 [95% CI, 0.60-18.91]), age (OR = 1.03 [95% CI, 0.96-1.10]), smoking (OR = 5.15 [95% CI, 0.51-51.44]), glucose (OR = 0.99 [95% CI, 0.97-1.01]), systolic arterial pressure (OR = 1.10 [CI 1.03-1.17]), diastolic arterial pressure (OR = 0.94 [CI 0.87-1.02]), dyslipidemia (OR = 1.46 [95% CI, 0.25-8.55]), estimated glomerular filtration rate (OR = 0.98 [95% CI, 0.96-1.01]), body mass index (OR = 1.03 [95% CI, 0.90-1.10]), and valvular and/or coronary disease (OR = 5.27 [95% CI, 1.02-27.21]).
The present study suggests that PTI could be a new biomarker of oxidative stress in patients with LVH.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0216359</identifier><identifier>PMID: 31067252</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Bioindicators ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Blood pressure ; Blood proteins ; Blood Proteins - metabolism ; Body mass ; Body mass index ; Body size ; Case-Control Studies ; Clinical medicine ; Coronary heart disease ; Diagnosis ; Dyslipidemia ; Echocardiography ; Electrocardiography ; Female ; Glomerular filtration rate ; Glucose ; Health aspects ; Heart ; Heart diseases ; Heart hypertrophy ; Heart surgery ; Heart valve diseases ; Humans ; Hypertension ; Hypertrophy ; Hypertrophy, Left Ventricular - diagnosis ; Hypertrophy, Left Ventricular - metabolism ; Kinases ; Male ; Measurement ; Medicine and Health Sciences ; Metabolic disorders ; Middle Aged ; Nitric oxide ; Oxidative Stress ; Patients ; Peptides ; Physical Sciences ; Physiological aspects ; Plasma levels ; Proteins ; Regression models ; Research and Analysis Methods ; Smoking ; Spectrophotometry ; Sulfhydryl Compounds - blood ; Sulfur compounds ; Thiols ; Ventricle</subject><ispartof>PloS one, 2019-05, Vol.14 (5), p.e0216359-e0216359</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Quintana-Villamandos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Quintana-Villamandos et al 2019 Quintana-Villamandos et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-d4c7b463125a062d56e2d226f1ef150fb140860dbe4074bf9cc3a6e81cb840aa3</citedby><cites>FETCH-LOGICAL-c593t-d4c7b463125a062d56e2d226f1ef150fb140860dbe4074bf9cc3a6e81cb840aa3</cites><orcidid>0000-0002-3685-2841 ; 0000-0002-8492-1565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505886/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505886/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31067252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shimosawa, Tatsuo</contributor><creatorcontrib>Quintana-Villamandos, Begoña</creatorcontrib><creatorcontrib>González Del Pozo, Irene</creatorcontrib><creatorcontrib>Pazó-Sayós, Laia</creatorcontrib><creatorcontrib>Bellón, Jose María</creatorcontrib><creatorcontrib>Pedraz-Prieto, Álvaro</creatorcontrib><creatorcontrib>Pinto, Ángel G</creatorcontrib><creatorcontrib>Delgado-Baeza, Emilio</creatorcontrib><title>Plasma protein thiolation index (PTI) as a potential biomarker for left ventricular hypertrophy in humans</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Left ventricular hypertrophy (LVH) has been associated with oxidative stress, although not with the protein thiolation index (PTI). This study explored the potential use of PTI as a biomarker of oxidative stress in patients with LVH.
We recruited 70 consecutive patients (n = 35 LVH and n = 35 non-LVH) based on an echocardiography study in our institution (left ventricular mass indexed to body surface area). Plasma levels of both S-thiolated protein and total thiols were measured as biomarkers of oxidative stress by spectrophotometry, and PTI was calculated as the molar ratio between S-thiolated proteins and the total thiol concentration.
Values for plasma S-thiolated proteins were higher in patients with LVH than in the control group (P = 0.01). There were no differences in total thiols between the LVH group and the control group. Finally, PTI was higher in patients with LVH than in the control group (P = 0.001). The area under the ROC curve was 0.75 (95% CI, 0.63-0.86; P<0.001), sensitivity was 70.6%, and specificity was 68.6%, thus suggesting that PTI could be used to screen for LVH. A multivariable logistic regression model showed a positive association (P = 0.02) between PTI and LVH (OR = 1.24 [95% CI, 1.03-1.49]) independently of gender (OR = 3.39 [95% CI, 0.60-18.91]), age (OR = 1.03 [95% CI, 0.96-1.10]), smoking (OR = 5.15 [95% CI, 0.51-51.44]), glucose (OR = 0.99 [95% CI, 0.97-1.01]), systolic arterial pressure (OR = 1.10 [CI 1.03-1.17]), diastolic arterial pressure (OR = 0.94 [CI 0.87-1.02]), dyslipidemia (OR = 1.46 [95% CI, 0.25-8.55]), estimated glomerular filtration rate (OR = 0.98 [95% CI, 0.96-1.01]), body mass index (OR = 1.03 [95% CI, 0.90-1.10]), and valvular and/or coronary disease (OR = 5.27 [95% CI, 1.02-27.21]).
The present study suggests that PTI could be a new biomarker of oxidative stress in patients with LVH.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Blood proteins</subject><subject>Blood Proteins - metabolism</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Case-Control Studies</subject><subject>Clinical medicine</subject><subject>Coronary heart disease</subject><subject>Diagnosis</subject><subject>Dyslipidemia</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Glomerular filtration rate</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Heart hypertrophy</subject><subject>Heart surgery</subject><subject>Heart valve diseases</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertrophy</subject><subject>Hypertrophy, Left Ventricular - diagnosis</subject><subject>Hypertrophy, Left Ventricular - metabolism</subject><subject>Kinases</subject><subject>Male</subject><subject>Measurement</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Oxidative Stress</subject><subject>Patients</subject><subject>Peptides</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Plasma levels</subject><subject>Proteins</subject><subject>Regression models</subject><subject>Research and Analysis Methods</subject><subject>Smoking</subject><subject>Spectrophotometry</subject><subject>Sulfhydryl Compounds - blood</subject><subject>Sulfur compounds</subject><subject>Thiols</subject><subject>Ventricle</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptkstu1DAUhiMEoqXwBggssSmLGXyJHWeDVFVcRqpEF2Vtnfgy48GJBzupmLfHw6RViyovbB1_5z8X_VX1luAlYQ35tI1TGiAsd3GwS0yJYLx9Vp2SltGFoJg9f_A-qV7lvMWYMynEy-qEESwayulp5a8D5B7QLsXR-gGNGx8DjD4OyA_G_kHn1zerjwgyKkxBhtFDQJ2PPaRfNiEXEwrWjei2fCWvpwAJbfY7m8YUd5t9UUGbqYchv65eOAjZvpnvs-rn1y83l98XVz--rS4vrhaat2xcmFo3XS0YoRywoIYLSw2lwhHrCMeuIzWWApvO1ripO9dqzUBYSXQnawzAzqr3R91diFnNW8qKUkokYwzXhVgdCRNhq3bJl1n2KoJX_wIxrRWk0etgVasbIY0jHcFt3UgDHCwzhjctdA7Xumh9nqtNXW-NPmwBwiPRxz-D36h1vFWCYy6lKALns0CKvyebR9X7rG0IMNg4HfpmRLasrKKgH_5Dn55uptZQBvCDi6WuPoiqCy5riTGTuFDLJ6hyjO29LpZyvsQfJdTHBJ1izsm6-xkJVgdD3jWjDoZUsyFL2ruH-7lPunMg-wsByN5V</recordid><startdate>20190508</startdate><enddate>20190508</enddate><creator>Quintana-Villamandos, Begoña</creator><creator>González Del Pozo, Irene</creator><creator>Pazó-Sayós, Laia</creator><creator>Bellón, Jose María</creator><creator>Pedraz-Prieto, Álvaro</creator><creator>Pinto, Ángel G</creator><creator>Delgado-Baeza, Emilio</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3685-2841</orcidid><orcidid>https://orcid.org/0000-0002-8492-1565</orcidid></search><sort><creationdate>20190508</creationdate><title>Plasma protein thiolation index (PTI) as a potential biomarker for left ventricular hypertrophy in humans</title><author>Quintana-Villamandos, Begoña ; González Del Pozo, Irene ; Pazó-Sayós, Laia ; Bellón, Jose María ; Pedraz-Prieto, Álvaro ; Pinto, Ángel G ; Delgado-Baeza, Emilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-d4c7b463125a062d56e2d226f1ef150fb140860dbe4074bf9cc3a6e81cb840aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bioindicators</topic><topic>Biological markers</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quintana-Villamandos, Begoña</au><au>González Del Pozo, Irene</au><au>Pazó-Sayós, Laia</au><au>Bellón, Jose María</au><au>Pedraz-Prieto, Álvaro</au><au>Pinto, Ángel G</au><au>Delgado-Baeza, Emilio</au><au>Shimosawa, Tatsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma protein thiolation index (PTI) as a potential biomarker for left ventricular hypertrophy in humans</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-05-08</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>e0216359</spage><epage>e0216359</epage><pages>e0216359-e0216359</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Left ventricular hypertrophy (LVH) has been associated with oxidative stress, although not with the protein thiolation index (PTI). This study explored the potential use of PTI as a biomarker of oxidative stress in patients with LVH.
We recruited 70 consecutive patients (n = 35 LVH and n = 35 non-LVH) based on an echocardiography study in our institution (left ventricular mass indexed to body surface area). Plasma levels of both S-thiolated protein and total thiols were measured as biomarkers of oxidative stress by spectrophotometry, and PTI was calculated as the molar ratio between S-thiolated proteins and the total thiol concentration.
Values for plasma S-thiolated proteins were higher in patients with LVH than in the control group (P = 0.01). There were no differences in total thiols between the LVH group and the control group. Finally, PTI was higher in patients with LVH than in the control group (P = 0.001). The area under the ROC curve was 0.75 (95% CI, 0.63-0.86; P<0.001), sensitivity was 70.6%, and specificity was 68.6%, thus suggesting that PTI could be used to screen for LVH. A multivariable logistic regression model showed a positive association (P = 0.02) between PTI and LVH (OR = 1.24 [95% CI, 1.03-1.49]) independently of gender (OR = 3.39 [95% CI, 0.60-18.91]), age (OR = 1.03 [95% CI, 0.96-1.10]), smoking (OR = 5.15 [95% CI, 0.51-51.44]), glucose (OR = 0.99 [95% CI, 0.97-1.01]), systolic arterial pressure (OR = 1.10 [CI 1.03-1.17]), diastolic arterial pressure (OR = 0.94 [CI 0.87-1.02]), dyslipidemia (OR = 1.46 [95% CI, 0.25-8.55]), estimated glomerular filtration rate (OR = 0.98 [95% CI, 0.96-1.01]), body mass index (OR = 1.03 [95% CI, 0.90-1.10]), and valvular and/or coronary disease (OR = 5.27 [95% CI, 1.02-27.21]).
The present study suggests that PTI could be a new biomarker of oxidative stress in patients with LVH.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31067252</pmid><doi>10.1371/journal.pone.0216359</doi><orcidid>https://orcid.org/0000-0002-3685-2841</orcidid><orcidid>https://orcid.org/0000-0002-8492-1565</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-05, Vol.14 (5), p.e0216359-e0216359 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2221833304 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Bioindicators Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Blood pressure Blood proteins Blood Proteins - metabolism Body mass Body mass index Body size Case-Control Studies Clinical medicine Coronary heart disease Diagnosis Dyslipidemia Echocardiography Electrocardiography Female Glomerular filtration rate Glucose Health aspects Heart Heart diseases Heart hypertrophy Heart surgery Heart valve diseases Humans Hypertension Hypertrophy Hypertrophy, Left Ventricular - diagnosis Hypertrophy, Left Ventricular - metabolism Kinases Male Measurement Medicine and Health Sciences Metabolic disorders Middle Aged Nitric oxide Oxidative Stress Patients Peptides Physical Sciences Physiological aspects Plasma levels Proteins Regression models Research and Analysis Methods Smoking Spectrophotometry Sulfhydryl Compounds - blood Sulfur compounds Thiols Ventricle |
| title | Plasma protein thiolation index (PTI) as a potential biomarker for left ventricular hypertrophy in humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T02%3A46%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20protein%20thiolation%20index%20(PTI)%20as%20a%20potential%20biomarker%20for%20left%20ventricular%20hypertrophy%20in%20humans&rft.jtitle=PloS%20one&rft.au=Quintana-Villamandos,%20Bego%C3%B1a&rft.date=2019-05-08&rft.volume=14&rft.issue=5&rft.spage=e0216359&rft.epage=e0216359&rft.pages=e0216359-e0216359&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0216359&rft_dat=%3Cgale_plos_%3EA584800380%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2221833304&rft_id=info:pmid/31067252&rft_galeid=A584800380&rft_doaj_id=oai_doaj_org_article_9c768df1b109478da5ae3dd579abf04c&rfr_iscdi=true |