Treatment of chronic HCV infection with DAAs in Rio de Janeiro/Brazil: SVR rates and baseline resistance analyses in NS5A and NS5B genes

The selection of viral strains with resistance-associated substitutions at hepatitis C virus (HCV) NS5A and NS5B genes is considered one of the limiting factors for achieving sustained virologic response (SVR) to combination of direct-acting antivirals daclatasvir (DCV) and sofosbuvir (SOF). Since 2...

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Veröffentlicht in:	PloS one 2019-05, Vol.14 (5), p.e0216327-e0216327
Hauptverfasser:	Costa, Vanessa D, Brandão-Mello, Carlos E, Nunes, Estevão P, Dos Santos Silva, Pedro Guilherme Corôa, de Souza Rodrigues, Lia Laura Lewis Ximenez, Lampe, Elisabeth, do Amaral Mello, Francisco Campello
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amino acids Antiviral agents Antiviral drugs Biodiversity Biological products industry Biological response modifiers Biology and Life Sciences Boceprevir Brazil Carbamates Chronic infection Clinical trials Comorbidity Disease resistance Drug Resistance, Viral - drug effects Drug Resistance, Viral - genetics Drug therapy Failure Female Gene sequencing Genes Genetic aspects Genetic diversity Genetic Variation Genotype Genotype & phenotype Genotypes Health aspects Hepacivirus - genetics Hepatitis Hepatitis C Hepatitis C - drug therapy Hepatitis C - genetics Hepatitis C virus Hepatology HIV Human immunodeficiency virus Humans Imidazoles - administration & dosage Infections Interferon Limiting factors Male Medical research Medicine and health sciences Middle Aged Mutation Patients People and places Phosphoproteins Physical Sciences Pyrrolidines Research and Analysis Methods RNA, Viral - genetics Sequence Analysis, RNA Sofosbuvir - administration & dosage Strains (organisms) Telaprevir Therapy Valine - analogs & derivatives Viral Nonstructural Proteins - genetics Virology Viruses
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