Simulated human digestion of N1-aryl-2-arylthioacetamidobenzimidazoles and their activity against Herpes-simplex virus 1 in vitro

Drug performance in the gastrointestinal tract (GIT) plays a crucial role in determining release and absorption. In the present work, we assessed the in vitro digestion of two synthetic N1-aryl-2-arylthioacetamidobenzimidazoles (NAABs), NAAB-496 and NAAB-503, using bio-relevant models of the human s...

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Veröffentlicht in:	PloS one 2019-05, Vol.14 (5), p.e0216384-e0216384
Hauptverfasser:	Mandalari, Giuseppina, Bisignano, Carlo, Smeriglio, Antonella, Denaro, Marcella, Musarra-Pizzo, Maria, Pennisi, Rosamaria, Mancuso, Francesca, Ferro, Stefania, Trombetta, Domenico, Monforte, Anna Maria, Sciortino, Maria Teresa, De Luca, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antiviral activity Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Aromatic compounds Benzimidazoles Biodegradation Biology and Life Sciences Chemistry Chromatography Computer simulation Diagnostic imaging Digestion Dosage and administration Engineering and Technology Environmental science Enzymes Formulations Future predictions Gastric Juice - metabolism Gastric Juice - virology Gastrointestinal system Gastrointestinal tract Health aspects Herpes simplex Herpes simplex virus Herpes viruses Herpesvirus 1, Human - growth & development Herpesvirus infections HIV Human immunodeficiency virus Humans Intestinal Secretions - metabolism Intestinal Secretions - virology Intestine, Small - metabolism Intestine, Small - virology Kinases Magnetic resonance Medicine and Health Sciences Models, Biological NMR Nuclear magnetic resonance Pepsin Pharmaceutical sciences Research and Analysis Methods Small intestine Stomach Stomach - virology Virtual environments Virus Inactivation - drug effects Virus replication Viruses
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