miRNAs, target genes expression and morphological analysis on the heart in gestational protein-restricted offspring

Gestational protein restriction was associated with low birth weight, hypertension and higher prevalence of cardiac disorders in adults. Several mechanisms, including epigenetics, could be related with the cardiovascular phenotype on protein-restricted offspring. Thus, we investigated the morphologi...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0210454-e0210454
Hauptverfasser:	Assalin, Heloisa Balan, Gontijo, José Antonio Rocha, Boer, Patrícia Aline
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Age Analysis Animals Animals, Newborn Aprotinin Biochemistry Birth weight Birth Weight - physiology Blood pressure Blood Pressure - physiology Body weight Body weight gain Cardiomyocytes Cardiovascular disease Childbirth & labor Collagen Diet Diet, Protein-Restricted - adverse effects Dietary restrictions DNA methylation EDTA Epidemiology Epigenetic inheritance Epigenetics Fatty acids Female Food Food intake Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental Gene regulation Genes Genetic crosses Heart Heart Ventricles - cytology Heart Ventricles - growth & development Heart Ventricles - physiopathology Homeostasis Hypertension Inositol polyphosphate 5-phosphatase Insulin Internal medicine Laboratory animals Low birth weight Low protein diet Male Maternal Exposure - adverse effects Medicine Metabolism Methyltransferases MicroRNA MicroRNAs - metabolism miRNA Morphology Myocytes Nutrient deficiency Offspring Phenotypes Physiology Pregnancy Pregnant women Prenatal Exposure Delayed Effects - genetics Prenatal Exposure Delayed Effects - physiopathology Proteins Rats Rats, Wistar Ribonucleic acid RNA Ventricle
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