Computational modeling of pancreatic cancer patients receiving FOLFIRINOX and gemcitabine-based therapies identifies optimum intervention strategies

Pancreatic ductal adenocarcinoma (PDAC) exhibits a variety of phenotypes with regard to disease progression and treatment response. This variability complicates clinical decision-making despite the improvement of survival due to the recent introduction of FOLFIRINOX (FFX) and nab-paclitaxel. Questio...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0215409
Hauptverfasser:	Yamamoto, Kimiyo N, Nakamura, Akira, Liu, Lin L, Stein, Shayna, Tramontano, Angela C, Kartoun, Uri, Shimizu, Tetsunosuke, Inoue, Yoshihiro, Asakuma, Mitsuhiro, Haeno, Hiroshi, Kong, Chung Yin, Uchiyama, Kazuhisa, Gonen, Mithat, Hur, Chin, Michor, Franziska
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adjuvant chemotherapy Aged Albumins - therapeutic use Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biology Biology and Life Sciences Breast cancer Cancer metastasis Cancer patients Cancer therapies Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Cell death Chemoradiotherapy - methods Chemotherapy Clinical Decision-Making Clinical medicine Computation Computer applications Computer Simulation Decision making Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Departments Development and progression Disease Progression Disease-Free Survival Drug Administration Schedule Drug therapy Feasibility Studies Female Fluorouracil - therapeutic use Gemcitabine Growth models Hospitals Humans Irinotecan - therapeutic use Kaplan-Meier Estimate Leucovorin - therapeutic use Male Mathematical models Medical diagnosis Medical schools Medical treatment Medicine and Health Sciences Metastases Metastasis Methods Middle Aged Models, Biological Neoadjuvant Therapy - methods Oncology Oxaliplatin - therapeutic use Paclitaxel Paclitaxel - therapeutic use Pancreas - pathology Pancreas - surgery Pancreatectomy Pancreatic cancer Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Parameter estimation Patients Phenotypes Public health Radiation Radiation (Physics) Radiation therapy Radiotherapy Remission Induction - methods Stem cells Surgery Survival Systematic review Therapeutics Tumor Burden Tumors
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