Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins

Most of the Parkinson's disease (PD) cases are sporadic, although several genes are directly related to PD. Several pathways are central in PD pathogenesis: protein aggregation linked to proteasomal impairments, mitochondrial dysfunctions and impairment in dopamine (DA) release. Here we studied...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0215277
Hauptverfasser:	Callizot, Noëlle, Combes, Maud, Henriques, Alexandre, Poindron, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - toxicity Agglomeration alpha-Synuclein - metabolism Animal models Animals Apoptosis Apoptosis - drug effects Autophagy Biochemistry Caspase Cell death Cells, Cultured Development and progression Dopamine Dopamine receptors Dopaminergic mechanisms Dopaminergic Neurons - cytology Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Embryo, Mammalian Energy Metabolism - drug effects Female Genes Health aspects Humans Inclusions Laboratory animals Lewy bodies Mesencephalon - cytology Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mortality Movement disorders MPP Mutation Necroptosis Necroptosis - drug effects Necrosis Necrosis - chemically induced Neurodegeneration Neurodegenerative diseases Neurons Neurotoxins Neurotoxins - toxicity Oxidative stress Oxidative Stress - drug effects Oxidopamine - toxicity Parkinson disease Parkinson Disease - etiology Parkinson Disease - pathology Parkinson's disease Pathogenesis Pathways Pharmacology Phenols (Class of compounds) Primary Cell Culture Proteasomes Protein Aggregation, Pathological - etiology Protein Aggregation, Pathological - pathology Protein interaction Proteins Rats Rotenone Rotenone - toxicity Synuclein Toxins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!