High resolution continuous arterial spin labeling of human cerebral perfusion using a separate neck tagging RF coil
For standard clinical applications, ASL images are typically acquired with 4-8 mm thick slices and 3-4 mm in-plane resolution. However, in this paper we demonstrate that high-resolution continuous arterial spin labeling (CASL) perfusion images can be acquired in a clinically relevant scan time using...
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| creator | Mora Álvarez, María Guadalupe Stobbe, Robert Wayne Beaulieu, Christian |
| description | For standard clinical applications, ASL images are typically acquired with 4-8 mm thick slices and 3-4 mm in-plane resolution. However, in this paper we demonstrate that high-resolution continuous arterial spin labeling (CASL) perfusion images can be acquired in a clinically relevant scan time using current MRI technology. CASL was implemented with a separate neck coil for labeling the arterial blood on a 4.7T MRI using standard axial 2D GE-EPI. Typical-resolution to high-resolution (voxels of 95, 60, 45, 27, or 7 mm3) images were compared for qualitative and quantitative cerebral blood flow analysis (CBF) in nine healthy volunteers (ages: 24-32 years). The highest resolution (1.5x1.5x3 = 7 mm3) CASL implementation yielded perfusion images with improved cortex depiction and increased cortical CBF measurements (53 ± 8 ml/100g/min), consistent with reduced partial volume averaging. The 7 mm3 voxel images were acquired with 6 cm brain coverage in a clinically relevant scan of 6 minutes. Improved spatial resolution facilitates CBF measurement with reduced partial volume averaging and may be valuable for the detection of perfusion deficits in small lesions and perfusion measurement in small brain regions. |
| doi_str_mv | 10.1371/journal.pone.0215998 |
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Improved spatial resolution facilitates CBF measurement with reduced partial volume averaging and may be valuable for the detection of perfusion deficits in small lesions and perfusion measurement in small brain regions.</description><subject>Adult</subject><subject>Arteries - diagnostic imaging</subject><subject>Arteries - physiology</subject><subject>Biomedical engineering</subject><subject>Blood</subject><subject>Blood flow</subject><subject>Brain</subject><subject>Brain damage</subject><subject>Brain research</subject><subject>Carotid arteries</subject><subject>Cerebral blood flow</subject><subject>Cerebral circulation</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cortex</subject><subject>Dentistry</subject><subject>Diagnostic imaging</subject><subject>Female</subject><subject>Gray Matter - diagnostic imaging</subject><subject>High resolution</subject><subject>Humans</subject><subject>Image acquisition</subject><subject>Image Processing, Computer-Assisted</subject><subject>Internet</subject><subject>Labeling</subject><subject>Labelling</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - 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Improved spatial resolution facilitates CBF measurement with reduced partial volume averaging and may be valuable for the detection of perfusion deficits in small lesions and perfusion measurement in small brain regions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31022257</pmid><doi>10.1371/journal.pone.0215998</doi><tpages>e0215998</tpages><orcidid>https://orcid.org/0000-0002-2342-3298</orcidid><orcidid>https://orcid.org/0000-0002-2165-6063</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Arteries - diagnostic imaging Arteries - physiology Biomedical engineering Blood Blood flow Brain Brain damage Brain research Carotid arteries Cerebral blood flow Cerebral circulation Cerebrovascular Circulation - physiology Cortex Dentistry Diagnostic imaging Female Gray Matter - diagnostic imaging High resolution Humans Image acquisition Image Processing, Computer-Assisted Internet Labeling Labelling Lesions Magnetic resonance imaging Magnetic Resonance Imaging - instrumentation Male Medical imaging Methods Neck Neck - diagnostic imaging Neuroimaging Perfusion Perfusion (Physiology) Qualitative analysis Spatial discrimination Spatial resolution Spin labeling Spin Labels Stroke Technology Therapeutic applications White Matter - diagnostic imaging Young Adult |
| title | High resolution continuous arterial spin labeling of human cerebral perfusion using a separate neck tagging RF coil |
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