The N-terminus of Sec61p plays key roles in ER protein import and ERAD

Sec61p is the channel-forming subunit of the heterotrimeric Sec61 complex that mediates co-translational protein import into the endoplasmic reticulum (ER). In yeast, proteins can also be post-translationally translocated by the hetero-heptameric Sec complex, composed of the Sec61 and the Sec63 comp...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0215950-e0215950
Hauptverfasser:	Elia, Francesco, Yadhanapudi, Lalitha, Tretter, Thomas, Römisch, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Amino acids Biodegradation Cytosol Defects Deoxyribonucleic acid Dislocations DNA EDTA Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress Endoplasmic Reticulum-Associated Degradation G proteins Imports Kinases Microbial Viability Microsomes - metabolism Mutation Mutation - genetics N-Terminus Plasmids Post-translation Protein folding Protein Stability Protein Structure, Secondary Protein Transport Proteins Saccharomyces cerevisiae - metabolism SEC Translocation Channels - chemistry SEC Translocation Channels - metabolism Translation Yeast Yeasts
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