Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats
Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was util...
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| description | Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was utilized in which pregnant rat dams were fed a low protein diet during both the gestation and lactation period. We subsequently analyzed lung mechanics using a FlexiVent ventilator in male and female pups at postnatal day 7 and 21. Lung lavage material was obtained at postnatal day 1, 7 and 21, and was used for analysis of the surfactant system which included measurement of the pool size of surfactant and its subfraction as well as the surface tension reducing ability of the surfactant. The main result of the study was a significantly lower lung compliance and higher tissue elastance which was observed in FGR female offspring at day 21 compared to control offspring. In addition, female LP offspring exhibited lower surfactant pool sizes at postnatal day 1compared to controls. These changes were not observed in the male offspring. It is concluded that FGR has a different impact on pulmonary function and on surfactant in female, as compared to male, offspring. |
| doi_str_mv | 10.1371/journal.pone.0215611 |
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This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was utilized in which pregnant rat dams were fed a low protein diet during both the gestation and lactation period. We subsequently analyzed lung mechanics using a FlexiVent ventilator in male and female pups at postnatal day 7 and 21. Lung lavage material was obtained at postnatal day 1, 7 and 21, and was used for analysis of the surfactant system which included measurement of the pool size of surfactant and its subfraction as well as the surface tension reducing ability of the surfactant. The main result of the study was a significantly lower lung compliance and higher tissue elastance which was observed in FGR female offspring at day 21 compared to control offspring. In addition, female LP offspring exhibited lower surfactant pool sizes at postnatal day 1compared to controls. These changes were not observed in the male offspring. It is concluded that FGR has a different impact on pulmonary function and on surfactant in female, as compared to male, offspring.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0215611</identifier><identifier>PMID: 31002676</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Air pollution ; Analysis ; Animal Nutritional Physiological Phenomena - physiology ; Animals ; Animals, Newborn ; Asthma ; Deflation (Economics) ; Development and progression ; Diet, Protein-Restricted - adverse effects ; Dwarfism ; Female ; Females ; Fetal development ; Fetal growth retardation ; Fetal Growth Retardation - etiology ; Fetal Growth Retardation - physiopathology ; Fetuses ; Gender differences ; Gestation ; Growth rate ; Health risk assessment ; Hypoxia ; Lactation ; Low protein diet ; Lung - growth & development ; Lung - metabolism ; Lung - physiopathology ; Lungs ; Male ; Males ; Mechanics (physics) ; Medical research ; Neonates ; Nutrient deficiency ; Offspring ; Pharmacology ; Physiology ; Pregnancy ; Proteins ; Pulmonary functions ; Pulmonary Surfactants - metabolism ; Rats, Wistar ; Respiratory function ; Respiratory Mechanics - physiology ; Risk factors ; Rodents ; Sex Factors ; Studies ; Surface active agents ; Surface tension ; Surfactants ; Women</subject><ispartof>PloS one, 2019-04, Vol.14 (4), p.e0215611-e0215611</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Khazaee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khazaee, Reza</au><au>McCaig, Lynda A</au><au>Yamashita, Cory</au><au>Hardy, Daniel B</au><au>Veldhuizen, Ruud A W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-04-19</date><risdate>2019</risdate><volume>14</volume><issue>4</issue><spage>e0215611</spage><epage>e0215611</epage><pages>e0215611-e0215611</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was utilized in which pregnant rat dams were fed a low protein diet during both the gestation and lactation period. We subsequently analyzed lung mechanics using a FlexiVent ventilator in male and female pups at postnatal day 7 and 21. Lung lavage material was obtained at postnatal day 1, 7 and 21, and was used for analysis of the surfactant system which included measurement of the pool size of surfactant and its subfraction as well as the surface tension reducing ability of the surfactant. The main result of the study was a significantly lower lung compliance and higher tissue elastance which was observed in FGR female offspring at day 21 compared to control offspring. In addition, female LP offspring exhibited lower surfactant pool sizes at postnatal day 1compared to controls. These changes were not observed in the male offspring. It is concluded that FGR has a different impact on pulmonary function and on surfactant in female, as compared to male, offspring.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31002676</pmid><doi>10.1371/journal.pone.0215611</doi><tpages>e0215611</tpages><orcidid>https://orcid.org/0000-0002-8802-1580</orcidid><orcidid>https://orcid.org/0000-0002-9681-023X</orcidid><orcidid>https://orcid.org/0000-0001-5445-273X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Air pollution Analysis Animal Nutritional Physiological Phenomena - physiology Animals Animals, Newborn Asthma Deflation (Economics) Development and progression Diet, Protein-Restricted - adverse effects Dwarfism Female Females Fetal development Fetal growth retardation Fetal Growth Retardation - etiology Fetal Growth Retardation - physiopathology Fetuses Gender differences Gestation Growth rate Health risk assessment Hypoxia Lactation Low protein diet Lung - growth & development Lung - metabolism Lung - physiopathology Lungs Male Males Mechanics (physics) Medical research Neonates Nutrient deficiency Offspring Pharmacology Physiology Pregnancy Proteins Pulmonary functions Pulmonary Surfactants - metabolism Rats, Wistar Respiratory function Respiratory Mechanics - physiology Risk factors Rodents Sex Factors Studies Surface active agents Surface tension Surfactants Women |
| title | Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats |
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