KSHV lytic proteins K-RTA and K8 bind to cellular and viral chromatin to modulate gene expression

The oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) has two distinct life cycles with lifelong latent/non-productive and a sporadic lytic-reactivating/productive phases in the infected immune compromised human hosts. The virus reactivates from latency in response to various chemical or...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0215394-e0215394
Hauptverfasser:	Kaul, Rajeev, Purushothaman, Pravinkumar, Uppal, Timsy, Verma, Subhash C
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Artificial chromosomes Assaying Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Binding proteins Binding sites Biology and Life Sciences Cell cycle Chromatin Chromatin - genetics Chromatin - metabolism Chromatin - virology Cloning Deoxyribonucleic acid Disease susceptibility DNA DNA biosynthesis DNA replication EDTA Electrophoretic mobility Environmental effects Gene expression Gene Expression Regulation, Viral - physiology Gene sequencing Genes Genomes Genomics HEK293 Cells Herpesvirus 8, Human - physiology Herpesviruses Humans Immunology Immunoprecipitation Infections Latency Life cycles Medicine Messenger RNA Next-generation sequencing Novels Nucleotide sequence Organic chemistry Penicillin Promoter Regions, Genetic Protein binding Proteins Quantitation Replication Repressor Proteins - genetics Repressor Proteins - metabolism Research and Analysis Methods RNA Sarcoma Tetracyclines Transcription Transcription (Genetics) Viral proteins Viral Proteins - genetics Viral Proteins - metabolism Virology Virus Activation - physiology Viruses
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