High SRC-1 and Twist1 expression predicts poor prognosis and promotes migration and invasion by inducing epithelial-mesenchymal transition in human nasopharyngeal carcinoma

Steroid receptor coactivator 1 (Src-1) and Twist1 are aberrantly upregulated in a variety of tumors and play an important role in tumor progression. However, the exact role of Src-1 and Twist1 in nasopharyngeal carcinoma (NPC) is uncertain. In this study, we investigated the possible prognostic valu...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0215299-e0215299
Hauptverfasser:	Zhou, Jingchun, Zhang, Jingjing, Xu, Ming, Ke, Zhaoyang, Zhang, Wei, Mai, Jiahao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Animals Apoptosis Assaying Biological effects Biological markers Biology and Life Sciences Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Cancer Cancer metastasis Cancer therapies Carcinoma Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement Colonies Development and progression E-cadherin Epithelial-Mesenchymal Transition - genetics Female Gastric cancer Gene expression Genetic aspects Genetic susceptibility Heterografts Humans Kaplan-Meier Estimate Kinases Liver cancer Male Medical prognosis Medical research Medicine and Health Sciences Melanoma Mesenchyme Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Middle Aged Multivariate analysis Nasopharyngeal cancer Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - genetics Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Receptor Coactivator 1 - genetics Nuclear Receptor Coactivator 1 - metabolism Otolaryngology Patients Prognosis Prostate cancer Radiation therapy Regression analysis Regression models Research and Analysis Methods Retrospective Studies RNA, Messenger - genetics RNA, Messenger - metabolism Stem cells Steroid receptor coactivator 1 Steroids Stomach cancer Survival Survival analysis Throat cancer Transcription factors Tumors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Up-Regulation Vimentin Wound care Wound healing Xenografts Xenotransplantation
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