Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury

Interruption of blood supply to the heart is a leading cause of death and disability. However, the molecular events that occur during heart ischemia, and how these changes prime consequent cell death upon reperfusion, are poorly understood. Protein SUMOylation is a post-translational modification th...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0213331-e0213331
Hauptverfasser:	Rawlings, Nadiia, Lee, Laura, Nakamura, Yasuko, Wilkinson, Kevin A, Henley, Jeremy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry Biology and Life Sciences Cardiac function Cardiomyocytes Care and treatment Cell death Cell Death - genetics Cell Survival Diagnosis Endopeptidases - genetics Enzymes Gene Knockout Techniques Heart Heart attack Humans Ischemia Ischemic Preconditioning, Myocardial - methods Medicine and Health Sciences Mortality Myocardial ischemia Myocardial Ischemia - genetics Myocardial Ischemia - pathology Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - pathology Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Oxidative Stress - genetics Perfusion Post-translation Post-translational modifications Preconditioning Proteases Proteins Rats Reperfusion Reperfusion injury RNA, Small Interfering - genetics Rodents Small Ubiquitin-Related Modifier Proteins - genetics SUMO protein Sumoylation - genetics Survival
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