Factors affecting mortality during the waiting time for kidney transplantation: A nationwide population-based cohort study using the Korean Network for Organ Sharing (KONOS) database
Long waiting time for deceased donor kidney transplant is inevitable due to the scarcity of donor, resulting in highlighting the importance of waiting time care. We analyzed the Korean Network for Organ Sharing (KONOS) database to assess the impact of waiting time on post-transplant survival outcome...
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| creator | Lee, Sunhwa Yoo, Kyung Don An, Jung Nam Oh, Yun Kyu Lim, Chun Soo Kim, Yon Su Lee, Jung Pyo |
| description | Long waiting time for deceased donor kidney transplant is inevitable due to the scarcity of donor, resulting in highlighting the importance of waiting time care. We analyzed the Korean Network for Organ Sharing (KONOS) database to assess the impact of waiting time on post-transplant survival outcomes and investigate risk factors for mortality by waiting time based on a complete enumeration survey in Korea.
We analyzed all persons aged over 18 years in deceased donor kidney transplant cases enrolled in the Korean Network for Organ Sharing (KONOS) database from January 2000 to January 2015. The primary end point was all-cause mortality after enrollment.
Of the 24,296 wait-listed subjects on dialysis, 5,255 patients received kidney transplants from deceased donors, with a median waiting time of 4.5 years. Longer waiting times had distinct deleterious effects on overall survival after transplantation. While waiting for a transplant, patients with diabetes were more likely to die before transplantation (HR 1.515, 95% CI 1.388-1.653, p |
| doi_str_mv | 10.1371/journal.pone.0212748 |
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We analyzed all persons aged over 18 years in deceased donor kidney transplant cases enrolled in the Korean Network for Organ Sharing (KONOS) database from January 2000 to January 2015. The primary end point was all-cause mortality after enrollment.
Of the 24,296 wait-listed subjects on dialysis, 5,255 patients received kidney transplants from deceased donors, with a median waiting time of 4.5 years. Longer waiting times had distinct deleterious effects on overall survival after transplantation. While waiting for a transplant, patients with diabetes were more likely to die before transplantation (HR 1.515, 95% CI 1.388-1.653, p<0.001). Age was another significant risk factor for mortality. Only 56% of people aged 65 years survived after 10 years of waiting, whereas 86% of people aged 35 years survived after 10 years. Moreover, women on the waiting list were more likely to live longer than men on the list.
More attention should be focused on patients with a higher risk of mortality while waiting for a deceased donor kidney transplant, such as patients with diabetes, those of advanced age, and those who are male.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0212748</identifier><identifier>PMID: 30978204</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Biology and Life Sciences ; Blood & organ donations ; Blood groups ; Cohort analysis ; Cohort Studies ; Data Management ; Databases, Factual ; Death ; Diabetes ; Diabetes mellitus ; Diabetics ; Dialysis ; Disease control ; Enumeration ; Female ; Gender ; Hemodialysis ; Hospital waiting lists ; Humans ; Internal medicine ; Kidney - physiopathology ; Kidney diseases ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Kidney transplants ; Kidneys ; Living Donors ; Male ; Medical research ; Medical waiting lists ; Medicine ; Medicine and Health Sciences ; Men ; Middle Aged ; Mortality ; Mortality risk ; Organ transplantation ; Patient outcomes ; Patients ; Population ; Population studies ; Population-based studies ; Quality of life ; Renal Dialysis ; Renal Insufficiency, Chronic - mortality ; Renal Insufficiency, Chronic - physiopathology ; Renal Insufficiency, Chronic - therapy ; Renal replacement therapy ; Republic of Korea ; Risk analysis ; Risk Factors ; Surgery ; Survival ; Transplantation ; Transplants ; Transplants & implants ; Waiting Lists</subject><ispartof>PloS one, 2019-04, Vol.14 (4), p.e0212748-e0212748</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Lee et al 2019 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-4e263dfc901d123e9063fbaae8ba1f9f82df0045ccf6a74b1997181057c4e6d93</citedby><cites>FETCH-LOGICAL-c593t-4e263dfc901d123e9063fbaae8ba1f9f82df0045ccf6a74b1997181057c4e6d93</cites><orcidid>0000-0002-4714-1260 ; 0000-0001-6545-6517</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461220/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461220/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30978204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sunhwa</creatorcontrib><creatorcontrib>Yoo, Kyung Don</creatorcontrib><creatorcontrib>An, Jung Nam</creatorcontrib><creatorcontrib>Oh, Yun Kyu</creatorcontrib><creatorcontrib>Lim, Chun Soo</creatorcontrib><creatorcontrib>Kim, Yon Su</creatorcontrib><creatorcontrib>Lee, Jung Pyo</creatorcontrib><title>Factors affecting mortality during the waiting time for kidney transplantation: A nationwide population-based cohort study using the Korean Network for Organ Sharing (KONOS) database</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Long waiting time for deceased donor kidney transplant is inevitable due to the scarcity of donor, resulting in highlighting the importance of waiting time care. We analyzed the Korean Network for Organ Sharing (KONOS) database to assess the impact of waiting time on post-transplant survival outcomes and investigate risk factors for mortality by waiting time based on a complete enumeration survey in Korea.
We analyzed all persons aged over 18 years in deceased donor kidney transplant cases enrolled in the Korean Network for Organ Sharing (KONOS) database from January 2000 to January 2015. The primary end point was all-cause mortality after enrollment.
Of the 24,296 wait-listed subjects on dialysis, 5,255 patients received kidney transplants from deceased donors, with a median waiting time of 4.5 years. Longer waiting times had distinct deleterious effects on overall survival after transplantation. While waiting for a transplant, patients with diabetes were more likely to die before transplantation (HR 1.515, 95% CI 1.388-1.653, p<0.001). Age was another significant risk factor for mortality. Only 56% of people aged 65 years survived after 10 years of waiting, whereas 86% of people aged 35 years survived after 10 years. Moreover, women on the waiting list were more likely to live longer than men on the list.
More attention should be focused on patients with a higher risk of mortality while waiting for a deceased donor kidney transplant, such as patients with diabetes, those of advanced age, and those who are male.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Blood & organ donations</subject><subject>Blood groups</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Data Management</subject><subject>Databases, Factual</subject><subject>Death</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetics</subject><subject>Dialysis</subject><subject>Disease control</subject><subject>Enumeration</subject><subject>Female</subject><subject>Gender</subject><subject>Hemodialysis</subject><subject>Hospital waiting lists</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical waiting lists</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mortality risk</subject><subject>Organ transplantation</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Quality of life</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - mortality</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Renal replacement therapy</subject><subject>Republic of Korea</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Survival</subject><subject>Transplantation</subject><subject>Transplants</subject><subject>Transplants & implants</subject><subject>Waiting 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affecting mortality during the waiting time for kidney transplantation: A nationwide population-based cohort study using the Korean Network for Organ Sharing (KONOS) database</title><author>Lee, Sunhwa ; Yoo, Kyung Don ; An, Jung Nam ; Oh, Yun Kyu ; Lim, Chun Soo ; Kim, Yon Su ; Lee, Jung Pyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-4e263dfc901d123e9063fbaae8ba1f9f82df0045ccf6a74b1997181057c4e6d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Blood & organ donations</topic><topic>Blood groups</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Data Management</topic><topic>Databases, Factual</topic><topic>Death</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetics</topic><topic>Dialysis</topic><topic>Disease 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mortality</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Renal replacement therapy</topic><topic>Republic of Korea</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Survival</topic><topic>Transplantation</topic><topic>Transplants</topic><topic>Transplants & implants</topic><topic>Waiting Lists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sunhwa</creatorcontrib><creatorcontrib>Yoo, Kyung Don</creatorcontrib><creatorcontrib>An, Jung Nam</creatorcontrib><creatorcontrib>Oh, Yun Kyu</creatorcontrib><creatorcontrib>Lim, Chun Soo</creatorcontrib><creatorcontrib>Kim, Yon Su</creatorcontrib><creatorcontrib>Lee, Jung Pyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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One</addtitle><date>2019-04-12</date><risdate>2019</risdate><volume>14</volume><issue>4</issue><spage>e0212748</spage><epage>e0212748</epage><pages>e0212748-e0212748</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Long waiting time for deceased donor kidney transplant is inevitable due to the scarcity of donor, resulting in highlighting the importance of waiting time care. We analyzed the Korean Network for Organ Sharing (KONOS) database to assess the impact of waiting time on post-transplant survival outcomes and investigate risk factors for mortality by waiting time based on a complete enumeration survey in Korea.
We analyzed all persons aged over 18 years in deceased donor kidney transplant cases enrolled in the Korean Network for Organ Sharing (KONOS) database from January 2000 to January 2015. The primary end point was all-cause mortality after enrollment.
Of the 24,296 wait-listed subjects on dialysis, 5,255 patients received kidney transplants from deceased donors, with a median waiting time of 4.5 years. Longer waiting times had distinct deleterious effects on overall survival after transplantation. While waiting for a transplant, patients with diabetes were more likely to die before transplantation (HR 1.515, 95% CI 1.388-1.653, p<0.001). Age was another significant risk factor for mortality. Only 56% of people aged 65 years survived after 10 years of waiting, whereas 86% of people aged 35 years survived after 10 years. Moreover, women on the waiting list were more likely to live longer than men on the list.
More attention should be focused on patients with a higher risk of mortality while waiting for a deceased donor kidney transplant, such as patients with diabetes, those of advanced age, and those who are male.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30978204</pmid><doi>10.1371/journal.pone.0212748</doi><orcidid>https://orcid.org/0000-0002-4714-1260</orcidid><orcidid>https://orcid.org/0000-0001-6545-6517</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-04, Vol.14 (4), p.e0212748-e0212748 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2209406614 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Aged Biology and Life Sciences Blood & organ donations Blood groups Cohort analysis Cohort Studies Data Management Databases, Factual Death Diabetes Diabetes mellitus Diabetics Dialysis Disease control Enumeration Female Gender Hemodialysis Hospital waiting lists Humans Internal medicine Kidney - physiopathology Kidney diseases Kidney transplantation Kidney Transplantation - adverse effects Kidney transplants Kidneys Living Donors Male Medical research Medical waiting lists Medicine Medicine and Health Sciences Men Middle Aged Mortality Mortality risk Organ transplantation Patient outcomes Patients Population Population studies Population-based studies Quality of life Renal Dialysis Renal Insufficiency, Chronic - mortality Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - therapy Renal replacement therapy Republic of Korea Risk analysis Risk Factors Surgery Survival Transplantation Transplants Transplants & implants Waiting Lists |
| title | Factors affecting mortality during the waiting time for kidney transplantation: A nationwide population-based cohort study using the Korean Network for Organ Sharing (KONOS) database |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T08%3A43%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Factors%20affecting%20mortality%20during%20the%20waiting%20time%20for%20kidney%20transplantation:%20A%20nationwide%20population-based%20cohort%20study%20using%20the%20Korean%20Network%20for%20Organ%20Sharing%20(KONOS)%20database&rft.jtitle=PloS%20one&rft.au=Lee,%20Sunhwa&rft.date=2019-04-12&rft.volume=14&rft.issue=4&rft.spage=e0212748&rft.epage=e0212748&rft.pages=e0212748-e0212748&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0212748&rft_dat=%3Cgale_plos_%3EA582174497%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2209406614&rft_id=info:pmid/30978204&rft_galeid=A582174497&rft_doaj_id=oai_doaj_org_article_b0960c28fe874779aaf253e056d360ec&rfr_iscdi=true |