Quantitative mass spectrometric analysis to unravel glycoproteomic signature of follicular fluid in women with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting women of reproductive age, and whose etiology is not well understood yet. In these women, the follicular growth is arrested at preantral stage leading to cyst formation, consequently resulting in anovulatory infertility in these...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0214742-e0214742
Hauptverfasser:	Patil, Krutika, Yelamanchi, Soujanya, Kumar, Manish, Hinduja, Indira, Prasad, T S Keshava, Gowda, Harsha, Mukherjee, Srabani
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Angiogenesis Bioinformatics Biology and Life Sciences Cardiovascular disease Cell adhesion & migration Chromatography Concanavalin A Criminal investigation Cysts Cytokines Diagnosis Disease control Endocrine disorders Endocrinology Etiology Etiology (Medicine) Extracellular matrix Female Fertilization in vitro Follicular cysts Follicular fluid Follicular Fluid - metabolism Gene Expression Profiling Glycoproteins Glycoproteins - metabolism Granulosa cells Health care Hospitals Human reproduction Humans Immunoblotting In vitro fertilization Infertility Insulin resistance Lectins Liquid chromatography Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Medical research Medicine and Health Sciences Mitogens Oligosaccharides Oocytes Ovarian Follicle - metabolism Peptides Polycystic ovary syndrome Polycystic Ovary Syndrome - metabolism Polymerase chain reaction Post-translation Proteins Proteomics Reagents Reproductive health Reproductive system Scientific imaging Spectroscopy Trypsin Tumor necrosis factor-TNF Type 2 diabetes Ultrasonic imaging Wheat Wheat germ Wheat germ agglutinin Women Womens health
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