DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS)

Whole-genome bisulfite sequencing (WGBS) and reduced representation bisulfite sequencing (RRBS) are widely used for measuring DNA methylation levels on a genome-wide scale. Both methods have limitations: WGBS is expensive and prohibitive for most large-scale projects; RRBS only interrogates 6-12% of...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0214368-e0214368
Hauptverfasser:	Bonora, Giancarlo, Rubbi, Liudmilla, Morselli, Marco, Ma, Feiyang, Chronis, Constantinos, Plath, Kathrin, Pellegrini, Matteo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioinformatics Biology and life sciences Bisulfite Cell Line Cellular Reprogramming Chromatin - metabolism Conversion CpG islands CpG Islands - genetics Deoxyribonucleic acid Developmental biology DNA DNA methylation DNA Methylation - genetics DNA Restriction Enzymes - metabolism DNA sequencing Enzymes Gene sequencing Genome Genomes Genomics Human genome Medical research Medicine Methods Methylation Mice Molecular biology Multiple regression models Physical Sciences Protocol Research and analysis methods Sequence Analysis, DNA - methods Stem cells Sulfites Sulfites - chemistry
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