Early extubation is not associated with severe intraventricular hemorrhage in preterm infants born before 29 weeks of gestation. Results of an EPIPAGE-2 cohort study
To determine whether there is an association between severe intraventricular hemorrhage and early extubation in preterm infants born before 29 weeks of gestational age and intubated at birth. This study included 1587 preterm infants from a nationwide French population cohort (EPIPAGE-2). Secondary d...
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| creator | Chevallier, Marie Ancel, Pierre-Yves Torchin, Héloïse Marchand-Martin, Laetitia Lorthe, Elsa Truffert, Patrick Jarreau, Pierre Henri Roze, Jean Christophe Pierrat, Véronique Marret, Stéphane Baud, Olivier Benhammou, Valérie Ego, Anne Debillon, Thierry |
| description | To determine whether there is an association between severe intraventricular hemorrhage and early extubation in preterm infants born before 29 weeks of gestational age and intubated at birth.
This study included 1587 preterm infants from a nationwide French population cohort (EPIPAGE-2). Secondary data on intubated preterm infants were analyzed. After gestational age and propensity score matching (1:1) we built two comparable groups: an early extubation group and a delayed extubation group. Each neonate in one group was paired with a neonate in the other group having the same propensity score and gestational age. Early extubation was defined as extubation within 48 hours of life. Severe intraventricular hemorrhages were defined as grade III or IV hemorrhages according to the Papile classification.
After matching, there were 398 neonates in each group. Using a generalized estimating equation model, we found that intraventricular hemorrhage was not associated with early extubation (adjusted OR 0.9, 95%CI 0.6-1.4). This result was supported by sensitivity analyses.
The practice of early extubation was not associated with an increased proportion of intraventricular hemorrhages. To complete these results, the long-term neurologic outcomes of these infants need to be assessed. |
| doi_str_mv | 10.1371/journal.pone.0214232 |
| format | Article |
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This study included 1587 preterm infants from a nationwide French population cohort (EPIPAGE-2). Secondary data on intubated preterm infants were analyzed. After gestational age and propensity score matching (1:1) we built two comparable groups: an early extubation group and a delayed extubation group. Each neonate in one group was paired with a neonate in the other group having the same propensity score and gestational age. Early extubation was defined as extubation within 48 hours of life. Severe intraventricular hemorrhages were defined as grade III or IV hemorrhages according to the Papile classification.
After matching, there were 398 neonates in each group. Using a generalized estimating equation model, we found that intraventricular hemorrhage was not associated with early extubation (adjusted OR 0.9, 95%CI 0.6-1.4). This result was supported by sensitivity analyses.
The practice of early extubation was not associated with an increased proportion of intraventricular hemorrhages. To complete these results, the long-term neurologic outcomes of these infants need to be assessed.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0214232</identifier><identifier>PMID: 30946750</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Airway Extubation - adverse effects ; Biology and Life Sciences ; Cerebral Hemorrhage - etiology ; Cohort analysis ; Cohort Studies ; Epidemiology ; Extubation ; Female ; Gestation ; Gestational age ; Health aspects ; Hemorrhage ; Humans ; Infant, Premature - physiology ; Infants ; Intensive care ; Intraventricular hemorrhage ; Intubation ; Life Sciences ; Matching ; Medicine and Health Sciences ; Methods ; Neonates ; Newborn babies ; Newborn infants ; Pediatrics ; Physical Sciences ; Population ; Pregnancy ; Premature babies ; Premature Birth - pathology ; Premature infants ; Propensity Score ; Research and Analysis Methods ; Respiratory therapy ; Risk Factors ; Sensitivity analysis ; Surfactants ; Ventilators</subject><ispartof>PloS one, 2019-04, Vol.14 (4), p.e0214232-e0214232</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Chevallier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2019 Chevallier et al 2019 Chevallier et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c753t-a1de1afd06306c64d45767a4b7bd7c12be2142fcb31c10c175db9be4a1eeac413</citedby><cites>FETCH-LOGICAL-c753t-a1de1afd06306c64d45767a4b7bd7c12be2142fcb31c10c175db9be4a1eeac413</cites><orcidid>0000-0002-1589-0144 ; 0000-0002-9654-8104 ; 0000-0001-5021-0522 ; 0000-0001-6568-0324 ; 0000-0002-1025-910X ; 0000-0003-4699-5384 ; 0000-0002-2858-148X ; 0000-0001-9947-270X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448867/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448867/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30946750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://normandie-univ.hal.science/hal-02451469$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chevallier, Marie</creatorcontrib><creatorcontrib>Ancel, Pierre-Yves</creatorcontrib><creatorcontrib>Torchin, Héloïse</creatorcontrib><creatorcontrib>Marchand-Martin, Laetitia</creatorcontrib><creatorcontrib>Lorthe, Elsa</creatorcontrib><creatorcontrib>Truffert, Patrick</creatorcontrib><creatorcontrib>Jarreau, Pierre Henri</creatorcontrib><creatorcontrib>Roze, Jean Christophe</creatorcontrib><creatorcontrib>Pierrat, Véronique</creatorcontrib><creatorcontrib>Marret, Stéphane</creatorcontrib><creatorcontrib>Baud, Olivier</creatorcontrib><creatorcontrib>Benhammou, Valérie</creatorcontrib><creatorcontrib>Ego, Anne</creatorcontrib><creatorcontrib>Debillon, Thierry</creatorcontrib><title>Early extubation is not associated with severe intraventricular hemorrhage in preterm infants born before 29 weeks of gestation. Results of an EPIPAGE-2 cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine whether there is an association between severe intraventricular hemorrhage and early extubation in preterm infants born before 29 weeks of gestational age and intubated at birth.
This study included 1587 preterm infants from a nationwide French population cohort (EPIPAGE-2). Secondary data on intubated preterm infants were analyzed. After gestational age and propensity score matching (1:1) we built two comparable groups: an early extubation group and a delayed extubation group. Each neonate in one group was paired with a neonate in the other group having the same propensity score and gestational age. Early extubation was defined as extubation within 48 hours of life. Severe intraventricular hemorrhages were defined as grade III or IV hemorrhages according to the Papile classification.
After matching, there were 398 neonates in each group. Using a generalized estimating equation model, we found that intraventricular hemorrhage was not associated with early extubation (adjusted OR 0.9, 95%CI 0.6-1.4). This result was supported by sensitivity analyses.
The practice of early extubation was not associated with an increased proportion of intraventricular hemorrhages. To complete these results, the long-term neurologic outcomes of these infants need to be assessed.</description><subject>Age</subject><subject>Airway Extubation - adverse effects</subject><subject>Biology and Life Sciences</subject><subject>Cerebral Hemorrhage - etiology</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Extubation</subject><subject>Female</subject><subject>Gestation</subject><subject>Gestational age</subject><subject>Health aspects</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Infant, Premature - physiology</subject><subject>Infants</subject><subject>Intensive care</subject><subject>Intraventricular hemorrhage</subject><subject>Intubation</subject><subject>Life Sciences</subject><subject>Matching</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Newborn infants</subject><subject>Pediatrics</subject><subject>Physical Sciences</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Premature babies</subject><subject>Premature Birth - pathology</subject><subject>Premature infants</subject><subject>Propensity Score</subject><subject>Research and Analysis Methods</subject><subject>Respiratory therapy</subject><subject>Risk Factors</subject><subject>Sensitivity analysis</subject><subject>Surfactants</subject><subject>Ventilators</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11r2zAUhs3YWLtu_2BsgsFYL5JJlvx1MwglawOFlu7jVhzLx7Eyx8okOV1-0P7n5CQtTenFMNji6Dnv8XmlE0VvGR0znrHPC9PbDtrxynQ4pjETMY-fRces4PEojSl__mB9FL1ybkFpwvM0fRkdcVqINEvocfR3CrbdEPzj-xK8Nh3RjnTGE3DOKA0eK3KrfUMcrtEi0Z23sMbw1qpvwZIGl8baBubDHllZ9GiXYVlD5x0pje1IibUJqXFBbhF_OWJqMkfnt-XG5AZd3_ptFDoyvZ5dT86no5go0xjrifN9tXkdvaihdfhm_z2Jfnydfj-7GF1enc_OJpcjlSXcj4BVyKCuaMppqlJRiSRLMxBlVlaZYnGJg021KjlTjCqWJVVZlCiAIYISjJ9E73e6q9Y4uXfYyTimIniZchGI2Y6oDCzkyuol2I00oOU2YOxcgvVatSgByyrhCS_KpAjaDIpQHSDJ86SqChoHrS_7an25xEoNrkJ7IHq40-lGzs1apkLkeZoFgdOdQPMo7WJyKYcYjUXCRFqsh9Y-7YtZ87sP9suldgrbFjo0_a7HNBd0K_vhEfq0E3tqDqHZcOAm_KMaROUkyVmc5KFwoMZPUOGpcKlVuLq1DvGDhNODhMD4cDvn0DsnZ99u_p-9-nnIfnzANgitb5xp--ESukNQ7EBljXMW63tnGZXD5N25IYfJk_vJC2nvHh7mfdLdqPF_oPAp_g</recordid><startdate>20190404</startdate><enddate>20190404</enddate><creator>Chevallier, Marie</creator><creator>Ancel, Pierre-Yves</creator><creator>Torchin, Héloïse</creator><creator>Marchand-Martin, Laetitia</creator><creator>Lorthe, Elsa</creator><creator>Truffert, Patrick</creator><creator>Jarreau, Pierre Henri</creator><creator>Roze, Jean Christophe</creator><creator>Pierrat, Véronique</creator><creator>Marret, Stéphane</creator><creator>Baud, Olivier</creator><creator>Benhammou, Valérie</creator><creator>Ego, Anne</creator><creator>Debillon, Thierry</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1589-0144</orcidid><orcidid>https://orcid.org/0000-0002-9654-8104</orcidid><orcidid>https://orcid.org/0000-0001-5021-0522</orcidid><orcidid>https://orcid.org/0000-0001-6568-0324</orcidid><orcidid>https://orcid.org/0000-0002-1025-910X</orcidid><orcidid>https://orcid.org/0000-0003-4699-5384</orcidid><orcidid>https://orcid.org/0000-0002-2858-148X</orcidid><orcidid>https://orcid.org/0000-0001-9947-270X</orcidid></search><sort><creationdate>20190404</creationdate><title>Early extubation is not associated with severe intraventricular hemorrhage in preterm infants born before 29 weeks of gestation. Results of an EPIPAGE-2 cohort study</title><author>Chevallier, Marie ; Ancel, Pierre-Yves ; Torchin, Héloïse ; Marchand-Martin, Laetitia ; Lorthe, Elsa ; Truffert, Patrick ; Jarreau, Pierre Henri ; Roze, Jean Christophe ; Pierrat, Véronique ; Marret, Stéphane ; Baud, Olivier ; Benhammou, Valérie ; Ego, Anne ; Debillon, Thierry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c753t-a1de1afd06306c64d45767a4b7bd7c12be2142fcb31c10c175db9be4a1eeac413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Airway Extubation - adverse effects</topic><topic>Biology and Life Sciences</topic><topic>Cerebral Hemorrhage - etiology</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Epidemiology</topic><topic>Extubation</topic><topic>Female</topic><topic>Gestation</topic><topic>Gestational age</topic><topic>Health aspects</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Infant, Premature - physiology</topic><topic>Infants</topic><topic>Intensive care</topic><topic>Intraventricular hemorrhage</topic><topic>Intubation</topic><topic>Life Sciences</topic><topic>Matching</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Newborn infants</topic><topic>Pediatrics</topic><topic>Physical Sciences</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Premature babies</topic><topic>Premature Birth - pathology</topic><topic>Premature infants</topic><topic>Propensity Score</topic><topic>Research and Analysis Methods</topic><topic>Respiratory therapy</topic><topic>Risk Factors</topic><topic>Sensitivity analysis</topic><topic>Surfactants</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chevallier, Marie</creatorcontrib><creatorcontrib>Ancel, Pierre-Yves</creatorcontrib><creatorcontrib>Torchin, Héloïse</creatorcontrib><creatorcontrib>Marchand-Martin, Laetitia</creatorcontrib><creatorcontrib>Lorthe, Elsa</creatorcontrib><creatorcontrib>Truffert, Patrick</creatorcontrib><creatorcontrib>Jarreau, Pierre Henri</creatorcontrib><creatorcontrib>Roze, Jean Christophe</creatorcontrib><creatorcontrib>Pierrat, Véronique</creatorcontrib><creatorcontrib>Marret, Stéphane</creatorcontrib><creatorcontrib>Baud, Olivier</creatorcontrib><creatorcontrib>Benhammou, Valérie</creatorcontrib><creatorcontrib>Ego, Anne</creatorcontrib><creatorcontrib>Debillon, Thierry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chevallier, Marie</au><au>Ancel, Pierre-Yves</au><au>Torchin, Héloïse</au><au>Marchand-Martin, Laetitia</au><au>Lorthe, Elsa</au><au>Truffert, Patrick</au><au>Jarreau, Pierre Henri</au><au>Roze, Jean Christophe</au><au>Pierrat, Véronique</au><au>Marret, Stéphane</au><au>Baud, Olivier</au><au>Benhammou, Valérie</au><au>Ego, Anne</au><au>Debillon, Thierry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early extubation is not associated with severe intraventricular hemorrhage in preterm infants born before 29 weeks of gestation. Results of an EPIPAGE-2 cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-04-04</date><risdate>2019</risdate><volume>14</volume><issue>4</issue><spage>e0214232</spage><epage>e0214232</epage><pages>e0214232-e0214232</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine whether there is an association between severe intraventricular hemorrhage and early extubation in preterm infants born before 29 weeks of gestational age and intubated at birth.
This study included 1587 preterm infants from a nationwide French population cohort (EPIPAGE-2). Secondary data on intubated preterm infants were analyzed. After gestational age and propensity score matching (1:1) we built two comparable groups: an early extubation group and a delayed extubation group. Each neonate in one group was paired with a neonate in the other group having the same propensity score and gestational age. Early extubation was defined as extubation within 48 hours of life. Severe intraventricular hemorrhages were defined as grade III or IV hemorrhages according to the Papile classification.
After matching, there were 398 neonates in each group. Using a generalized estimating equation model, we found that intraventricular hemorrhage was not associated with early extubation (adjusted OR 0.9, 95%CI 0.6-1.4). This result was supported by sensitivity analyses.
The practice of early extubation was not associated with an increased proportion of intraventricular hemorrhages. To complete these results, the long-term neurologic outcomes of these infants need to be assessed.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30946750</pmid><doi>10.1371/journal.pone.0214232</doi><tpages>e0214232</tpages><orcidid>https://orcid.org/0000-0002-1589-0144</orcidid><orcidid>https://orcid.org/0000-0002-9654-8104</orcidid><orcidid>https://orcid.org/0000-0001-5021-0522</orcidid><orcidid>https://orcid.org/0000-0001-6568-0324</orcidid><orcidid>https://orcid.org/0000-0002-1025-910X</orcidid><orcidid>https://orcid.org/0000-0003-4699-5384</orcidid><orcidid>https://orcid.org/0000-0002-2858-148X</orcidid><orcidid>https://orcid.org/0000-0001-9947-270X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-04, Vol.14 (4), p.e0214232-e0214232 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2204193634 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Airway Extubation - adverse effects Biology and Life Sciences Cerebral Hemorrhage - etiology Cohort analysis Cohort Studies Epidemiology Extubation Female Gestation Gestational age Health aspects Hemorrhage Humans Infant, Premature - physiology Infants Intensive care Intraventricular hemorrhage Intubation Life Sciences Matching Medicine and Health Sciences Methods Neonates Newborn babies Newborn infants Pediatrics Physical Sciences Population Pregnancy Premature babies Premature Birth - pathology Premature infants Propensity Score Research and Analysis Methods Respiratory therapy Risk Factors Sensitivity analysis Surfactants Ventilators |
| title | Early extubation is not associated with severe intraventricular hemorrhage in preterm infants born before 29 weeks of gestation. Results of an EPIPAGE-2 cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T00%3A22%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20extubation%20is%20not%20associated%20with%20severe%20intraventricular%20hemorrhage%20in%20preterm%20infants%20born%20before%2029%20weeks%20of%20gestation.%20Results%20of%20an%20EPIPAGE-2%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Chevallier,%20Marie&rft.date=2019-04-04&rft.volume=14&rft.issue=4&rft.spage=e0214232&rft.epage=e0214232&rft.pages=e0214232-e0214232&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0214232&rft_dat=%3Cgale_plos_%3EA581258469%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2204193634&rft_id=info:pmid/30946750&rft_galeid=A581258469&rft_doaj_id=oai_doaj_org_article_aebd53539b594131a9214aa5885dd902&rfr_iscdi=true |