Sodium thiocyanate treatment attenuates atherosclerotic plaque formation and improves endothelial regeneration in mice

Atherosclerotic plaque formation is an inflammatory process that involves the recruitment of neutrophil granulocytes and the generation of reactive oxygen species (ROS). ROS formation by myeloperoxidase, a key enzyme in H2O2 degradation, can be modulated by addition of sodium thiocyanate (NaSCN). Ho...

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Veröffentlicht in:	PloS one 2019-04, Vol.14 (4), p.e0214476-e0214476
Hauptverfasser:	Zietzer, Andreas, Niepmann, Sven Thomas, Camara, Bakary, Lenart, Monika Anna, Jansen, Felix, Becher, Marc Ulrich, Andrié, René, Nickenig, Georg, Tiyerili, Vedat
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis Animals Aorta Aorta - metabolism Apolipoprotein E Apolipoproteins Arteriosclerosis Atherogenesis Atherosclerosis Atherosclerotic plaque Biology and Life Sciences Blood levels Blood Pressure Body Weight Cardiovascular diseases Care and treatment Carotid Arteries - pathology Carotid artery Causes of Chemiluminescence Cholesterol Control Damage assessment Endothelium Endothelium, Vascular - metabolism Enzymes Granulocytes - metabolism Health aspects Heart Heart attacks Heart Rate - drug effects Hospitals Hydrogen Peroxide In vivo methods and tests Infiltration Inflammation Interleukin 10 Interleukin 6 Leukocytes (granulocytic) Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout, ApoE Monocytes Mortality Neointima - pathology Neutrophils - metabolism Organic chemistry Oxidation Oxidative Stress Oxygen Patient outcomes Peroxidase Peroxidase - metabolism Physical Sciences Plaque, Atherosclerotic - drug therapy Plaque, Atherosclerotic - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Regeneration Research and Analysis Methods Risk factors Rodents Serum levels Sodium Sodium thiocyanate Thiocyanates Thiocyanates - metabolism Thiocyanates - pharmacology Vasodilation Vasodilation - drug effects
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