Meso scale discovery-based assays for the detection of aggregated huntingtin

Huntington's disease (HD) is a monogenic neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin (HTT) gene, leading to an expanded poly-glutamine (polyQ) stretch in the HTT protein. This mutant HTT (mHTT) protein is highly prone to intracellul...

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Veröffentlicht in:	PloS one 2019-03, Vol.14 (3), p.e0213521-e0213521
Hauptverfasser:	Reindl, Wolfgang, Baldo, Barbara, Schulz, Jana, Janack, Isabell, Lindner, Ilka, Kleinschmidt, Markus, Sedaghat, Yalda, Thiede, Christina, Tillack, Karsten, Schmidt, Christina, Cardaun, Isabell, Schwagarus, Tom, Herrmann, Frank, Hotze, Madlen, Osborne, Georgina F, Herrmann, Simone, Weiss, Andreas, Zerbinatti, Celina, Bates, Gillian P, Bard, Jonathan, Munoz-Sanjuan, Ignacio, Macdonald, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alzheimer's disease Alzheimers disease Amino acids Animal models Animals Assaying Biological Assay Biological properties Biological samples Biology and Life Sciences Brain Brain - metabolism Change detection Chromatography Clinical trials Cortex Dementia Diagnosis Discovery and exploration Disease Models, Animal Drug development Economic models Enzyme-linked immunosorbent assay Genes Glutamine Humans Huntingtin Huntingtin Protein - genetics Huntingtin Protein - metabolism Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Huntington's disease Huntingtons disease Intracellular Lysates Medical research Medicine and Health Sciences Mice Mice, Transgenic Monomers Neostriatum Nervous system diseases Neurodegenerative diseases Neuropathology Peptides - genetics Peptides - metabolism Physical Sciences Polyglutamine Protein Aggregation, Pathological - genetics Protein Aggregation, Pathological - metabolism Protein Aggregation, Pathological - pathology Proteins Research and Analysis Methods Size exclusion chromatography Species Supervision Technology Therapeutics Time dependence Trinucleotide repeats University colleges Zinc Zinc finger proteins
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