Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children: A study based on a cohort of institutionalized infants and toddlers
Early social deprivation (i.e., an insufficiency or lack of parental care) has been identified as a significant adverse early experience that may affect multiple facets of child development and cause long-term outcomes in physical and mental health, cognition and behavior. Current research provides...
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| Veröffentlicht in: | PloS one 2019-03, Vol.14 (3), p.e0214285-e0214285 |
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| creator | Naumova, Oxana Yu Rychkov, Sergey Yu Kornilov, Sergey A Odintsova, Veronika V Anikina, Varvara О Solodunova, Maria Yu Arintcina, Irina A Zhukova, Marina A Ovchinnikova, Irina V Burenkova, Olga V Zhukova, Olga V Muhamedrahimov, Rifkat J Grigorenko, Elena L |
| description | Early social deprivation (i.e., an insufficiency or lack of parental care) has been identified as a significant adverse early experience that may affect multiple facets of child development and cause long-term outcomes in physical and mental health, cognition and behavior. Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization-the immersion in an extreme socially depriving environment in humans-on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. Moreover, some of these methylation states may directly modulate the behavioral deficits; according to preliminary estimates, about 7-14% of the deviation of adaptive behavior between groups of children may be determined by their difference in DNA methylation profiles. The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children. |
| doi_str_mv | 10.1371/journal.pone.0214285 |
| format | Article |
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Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization-the immersion in an extreme socially depriving environment in humans-on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. Moreover, some of these methylation states may directly modulate the behavioral deficits; according to preliminary estimates, about 7-14% of the deviation of adaptive behavior between groups of children may be determined by their difference in DNA methylation profiles. The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0214285</identifier><identifier>PMID: 30913238</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptation, Psychological ; Analysis ; Behavior ; Biology and life sciences ; Blood cells ; Child behavior ; Child development ; Child, Institutionalized ; Child, Preschool ; Children ; Children & youth ; Cognition ; Cross-Sectional Studies ; Deoxyribonucleic acid ; Deprivation ; DNA ; DNA Methylation ; Domains ; Early experience ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Family ; Family relations ; Gene expression ; Gene Regulatory Networks ; Genomes ; Genomics ; Health ; Humans ; Hypotheses ; Immune system ; Infant ; Infants ; Institutionalization ; Laboratories ; Medicine ; Medicine and Health Sciences ; Mental health ; Methylation ; Neurobiology ; Neurosciences ; Orphanages ; Parenting ; People and Places ; Principal Component Analysis ; Receptors, Glucocorticoid - genetics ; Significance ; Social behavior ; Social Sciences ; Statistical analysis ; Statistical significance ; Stress ; Submerging ; Toddlers</subject><ispartof>PloS one, 2019-03, Vol.14 (3), p.e0214285-e0214285</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Naumova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization-the immersion in an extreme socially depriving environment in humans-on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. 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The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children.</description><subject>Adaptation, Psychological</subject><subject>Analysis</subject><subject>Behavior</subject><subject>Biology and life sciences</subject><subject>Blood cells</subject><subject>Child behavior</subject><subject>Child development</subject><subject>Child, Institutionalized</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cognition</subject><subject>Cross-Sectional Studies</subject><subject>Deoxyribonucleic acid</subject><subject>Deprivation</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>Domains</subject><subject>Early experience</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Family</subject><subject>Family relations</subject><subject>Gene expression</subject><subject>Gene Regulatory Networks</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Immune system</subject><subject>Infant</subject><subject>Infants</subject><subject>Institutionalization</subject><subject>Laboratories</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mental health</subject><subject>Methylation</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Orphanages</subject><subject>Parenting</subject><subject>People and Places</subject><subject>Principal Component Analysis</subject><subject>Receptors, Glucocorticoid - genetics</subject><subject>Significance</subject><subject>Social behavior</subject><subject>Social Sciences</subject><subject>Statistical analysis</subject><subject>Statistical 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Yu</au><au>Kornilov, Sergey A</au><au>Odintsova, Veronika V</au><au>Anikina, Varvara О</au><au>Solodunova, Maria Yu</au><au>Arintcina, Irina A</au><au>Zhukova, Marina A</au><au>Ovchinnikova, Irina V</au><au>Burenkova, Olga V</au><au>Zhukova, Olga V</au><au>Muhamedrahimov, Rifkat J</au><au>Grigorenko, Elena L</au><au>El-Maarri, Osman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children: A study based on a cohort of institutionalized infants and toddlers</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-03-26</date><risdate>2019</risdate><volume>14</volume><issue>3</issue><spage>e0214285</spage><epage>e0214285</epage><pages>e0214285-e0214285</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Early social deprivation (i.e., an insufficiency or lack of parental care) has been identified as a significant adverse early experience that may affect multiple facets of child development and cause long-term outcomes in physical and mental health, cognition and behavior. Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization-the immersion in an extreme socially depriving environment in humans-on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. Moreover, some of these methylation states may directly modulate the behavioral deficits; according to preliminary estimates, about 7-14% of the deviation of adaptive behavior between groups of children may be determined by their difference in DNA methylation profiles. The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30913238</pmid><doi>10.1371/journal.pone.0214285</doi><tpages>e0214285</tpages><orcidid>https://orcid.org/0000-0002-9868-6981</orcidid><orcidid>https://orcid.org/0000-0001-5950-5765</orcidid><orcidid>https://orcid.org/0000-0002-9440-6276</orcidid><orcidid>https://orcid.org/0000-0001-5746-1287</orcidid><orcidid>https://orcid.org/0000-0003-0889-526X</orcidid><orcidid>https://orcid.org/0000-0002-8378-110X</orcidid><orcidid>https://orcid.org/0000-0002-1519-9847</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-03, Vol.14 (3), p.e0214285-e0214285 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2199461583 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adaptation, Psychological Analysis Behavior Biology and life sciences Blood cells Child behavior Child development Child, Institutionalized Child, Preschool Children Children & youth Cognition Cross-Sectional Studies Deoxyribonucleic acid Deprivation DNA DNA Methylation Domains Early experience Epigenesis, Genetic Epigenetic inheritance Epigenetics Family Family relations Gene expression Gene Regulatory Networks Genomes Genomics Health Humans Hypotheses Immune system Infant Infants Institutionalization Laboratories Medicine Medicine and Health Sciences Mental health Methylation Neurobiology Neurosciences Orphanages Parenting People and Places Principal Component Analysis Receptors, Glucocorticoid - genetics Significance Social behavior Social Sciences Statistical analysis Statistical significance Stress Submerging Toddlers |
| title | Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children: A study based on a cohort of institutionalized infants and toddlers |
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