Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer

Metabolic reprogramming is considered a hallmark of cancer. Currently, the altered lipid metabolism in cancer is a topic of interest due to the prominent role of lipids regulating the progression of various types of tumors. Lipids and lipid-derived molecules have been shown to activate growth regula...

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Veröffentlicht in:	PloS one 2019-03, Vol.14 (3), p.e0214294-e0214294
Hauptverfasser:	Mouhid, Lamia, Gómez de Cedrón, Marta, García-Carrascosa, Elena, Reglero, Guillermo, Fornari, Tiziana, Ramírez de Molina, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Achillea - chemistry Achillea - metabolism Adjuvant chemotherapy Analysis Animals Anticancer properties Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Biocompatibility Biology and Life Sciences Cancer Cancer cells Cancer therapies Carbon dioxide Cell growth Cell Line, Tumor Cell Movement - drug effects Chemotherapy Cholesterol Cytotoxicity Desaturase Dietary supplements Down-Regulation - drug effects Enzymes Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty acid synthesis Fatty acids Fatty-acid synthase Food science Genes Genomics Health aspects Homeostasis Humans Lipid metabolism Lipid Metabolism - drug effects Lipids Male Malignancy Medical prognosis Medicine and Health Sciences Metabolism Mice Mice, Nude Molecular modelling Oncology Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Phytochemicals Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Research and Analysis Methods Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - genetics Stearoyl-CoA Desaturase - metabolism Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sterols Supercritical gas extraction Toxicity Transplantation, Heterologous Tumors Xenografts Xenotransplantation
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