Amelioration of Huntington's disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington's disease monkeys

Huntington's disease (HD) is a devastating monogenic, dominant, hereditary, neurodegenerative disease. HD is caused by the expansion of CAG repeats in exon 1 of the huntingtin (HTT) gene, IT15, resulting in an expanded polyglutamine (polyQ) residue in the N-terminus of the HTT protein. HD is ch...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2019-03, Vol.14 (3), p.e0214156-e0214156
Hauptverfasser:	Cho, In Ki, Yang, Bo, Forest, Craig, Qian, Lu, Chan, Anthony W S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyotrophic lateral sclerosis Analysis Animals Animals, Genetically Modified Apoptosis Astrocytes Astrocytes - cytology Astrocytes - pathology Atrophy Bioengineering Biology and Life Sciences Brain Brain research Cell Differentiation Cells (biology) Cells, Cultured Central nervous system Cognitive ability Disease Disease Models, Animal Electrophysiology Flow cytometry Gene expression Genes Genetic engineering Glial cells Glial fibrillary acidic protein Glutamate Haplorhini High definition television Homeostasis Humans Huntingtin Huntingtin Protein - genetics Huntington Disease - genetics Huntington Disease - pathology Huntington's disease Huntingtons disease Inclusion bodies Inclusions Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - pathology Inhibitory postsynaptic potentials Medicine and Health Sciences Monkeys Movement disorders Mutation N-Terminus Neostriatum Nervous system diseases Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - pathology Neurodegeneration Neurodegenerative diseases Neurogenesis Neurological diseases Neuronal-glial interactions Neurons Neurosciences Novels Parkinson's disease Pathogenesis Phenotypes Primates Progenitor cells Proteins Ribonucleic acid RNA RNA interference Stem cells Superoxide dismutase Trends
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!