Whole-body and segmental analysis of body composition in adult males with achondroplasia using dual X-ray absorptiometry
Achondroplasia is a condition characterized by a genetic mutation affecting long bone endplate development. Current data suggests that the bone mineral content (BMC) and bone mineral density (BMD) of achondroplasic populations are below age matched individuals of average stature (controls). Due to t...
Gespeichert in:
| Veröffentlicht in: | PloS one 2019-03, Vol.14 (3), p.e0213806 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | e0213806 |
| container_title | PloS one |
| container_volume | 14 |
| creator | Sims, David Onambélé-Pearson, Gladys Burden, Adrian Payton, Carl Morse, Christopher |
| description | Achondroplasia is a condition characterized by a genetic mutation affecting long bone endplate development. Current data suggests that the bone mineral content (BMC) and bone mineral density (BMD) of achondroplasic populations are below age matched individuals of average stature (controls). Due to the disproportionate limb-to-torso length compared to controls however, the lower BMC and BMD may be nullified when appropriately presented. The aim of this study was to measure whole-body and segmental body composition in adult males with achondroplasia (N = 10, 22 ±3 yrs), present data relative to whole-body and whole-limb values and compare all values to age matched controls (N = 17, 22 ±2 yrs). Dual X-ray absorptiometry (DEXA) was used to measure the in vivo mass of the whole-body and 15 segments, from which BMD, BMC, fat free mass (FFM) and body fat mass were measured. BMC of lumbar vertebrae (L1-4) was also measured and presented as a volumetric BMD (BMDVOL). The achondroplasic group had less BMC, BMD and FFM, and more body fat mass than controls as a whole-body measure. The lower achondroplasic BMC and BMD was somewhat nullified when presented relative to whole-body and whole-limb values respectively. There was no difference in lumbar BMDVOL between groups. Whole-body BMD measures presented the achondroplasic group as 'osteopenic'. When relative to whole-limb measures however, achondroplasic BMD descriptions were normal. Further work is needed to create a body composition database for achondroplasic population's, or for clinicians to present achondroplasic body composition values relative to the whole-limb. |
| doi_str_mv | 10.1371/journal.pone.0213806 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2194690502</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A579246905</galeid><doaj_id>oai_doaj_org_article_5d817adf7afa490fb2fc0fbe71df7edc</doaj_id><sourcerecordid>A579246905</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-be537b4422e0a978215c913e9ddb950c1c30a10ae92c249fe45ff715440651103</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QLguhFxyRNP3IjLIsfAwsLft-F0zRpM6RNN2l159-bmekuU9kLCTTpyfO-aU_OiaLnGK1wWuB3Gzu5HsxqsL1cIYLTEuUPolPMUpLkBKUPj9Yn0RPvNwhlaZnnj6OTFJUlwyw_jW5-ttbIpLL1Noa-jr1sOtmPYMIbmK3XPrYq3m8L2w3W61HbPtZ9DPVkxrgDI338R49tDKK1fe3sYMBriCev-yaup2D1K3EQ7Ctv3RDknRzd9mn0SIHx8tk8n0XfP374dvE5ubz6tL44v0xEzsiYVDJLi4pSQiQCVpQEZ4LhVLK6rliGBBYpAoxAMiIIZUrSTKkCZ5SiPMMYpWfRy4PvYKznc9I8J5jRnKEMkUCsD0RtYcMHpztwW25B833AuoaDG7Uwkmd1iQuoVQEKKEOqIkqEpyxwiMlaBK_382lT1YVASKUDszBd7vS65Y39zXNKKMVlMHgzGzh7PUk_8k57IY2BXtrp8N1ZSTFhAX31D3r_381UE26K617ZcK7YmfLzrGBkzwVqdQ8VRi07LUKFKR3iC8HbhSAwo7wZG5i85-uvX_6fvfqxZF8fsa0EM7bemmlXdX4J0gMonPXeSXWXZIz4rkFus8F3DcLnBgmyF8cXdCe67Yj0LxQQDUI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2194690502</pqid></control><display><type>article</type><title>Whole-body and segmental analysis of body composition in adult males with achondroplasia using dual X-ray absorptiometry</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Sims, David ; Onambélé-Pearson, Gladys ; Burden, Adrian ; Payton, Carl ; Morse, Christopher</creator><contributor>Reddy, Sakamuri V.</contributor><creatorcontrib>Sims, David ; Onambélé-Pearson, Gladys ; Burden, Adrian ; Payton, Carl ; Morse, Christopher ; Reddy, Sakamuri V.</creatorcontrib><description>Achondroplasia is a condition characterized by a genetic mutation affecting long bone endplate development. Current data suggests that the bone mineral content (BMC) and bone mineral density (BMD) of achondroplasic populations are below age matched individuals of average stature (controls). Due to the disproportionate limb-to-torso length compared to controls however, the lower BMC and BMD may be nullified when appropriately presented. The aim of this study was to measure whole-body and segmental body composition in adult males with achondroplasia (N = 10, 22 ±3 yrs), present data relative to whole-body and whole-limb values and compare all values to age matched controls (N = 17, 22 ±2 yrs). Dual X-ray absorptiometry (DEXA) was used to measure the in vivo mass of the whole-body and 15 segments, from which BMD, BMC, fat free mass (FFM) and body fat mass were measured. BMC of lumbar vertebrae (L1-4) was also measured and presented as a volumetric BMD (BMDVOL). The achondroplasic group had less BMC, BMD and FFM, and more body fat mass than controls as a whole-body measure. The lower achondroplasic BMC and BMD was somewhat nullified when presented relative to whole-body and whole-limb values respectively. There was no difference in lumbar BMDVOL between groups. Whole-body BMD measures presented the achondroplasic group as 'osteopenic'. When relative to whole-limb measures however, achondroplasic BMD descriptions were normal. Further work is needed to create a body composition database for achondroplasic population's, or for clinicians to present achondroplasic body composition values relative to the whole-limb.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0213806</identifier><identifier>PMID: 30889196</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Absorptiometry ; Absorptiometry, Photon - methods ; Achondroplasia ; Achondroplasia - diagnostic imaging ; Achondroplasia - epidemiology ; Achondroplasia - pathology ; Adult ; Adults ; Biocompatibility ; Biology and Life Sciences ; Biomedical materials ; Body Composition ; Body fat ; Bone Density ; Bone mineral content ; Bone mineral density ; Bones ; Cardiovascular disease ; Care and treatment ; Case-Control Studies ; Dual energy X-ray absorptiometry ; Dwarfism ; England - epidemiology ; Exercise ; Gene mutation ; Genetic aspects ; Humans ; Image Processing, Computer-Assisted - methods ; Long bone ; Male ; Males ; Medicine and Health Sciences ; Metabolic syndrome ; Minerals - analysis ; Mortality ; Mutation ; Obesity ; Older people ; Osteoporosis ; Physiology ; Predictive Value of Tests ; Radiography ; Studies ; Systematic review ; Torso ; Vertebrae ; Weight control ; Whole Body Imaging - methods ; Young Adult</subject><ispartof>PloS one, 2019-03, Vol.14 (3), p.e0213806</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Sims et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Sims et al 2019 Sims et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-be537b4422e0a978215c913e9ddb950c1c30a10ae92c249fe45ff715440651103</citedby><cites>FETCH-LOGICAL-c692t-be537b4422e0a978215c913e9ddb950c1c30a10ae92c249fe45ff715440651103</cites><orcidid>0000-0003-0152-866X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424418/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424418/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30889196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Reddy, Sakamuri V.</contributor><creatorcontrib>Sims, David</creatorcontrib><creatorcontrib>Onambélé-Pearson, Gladys</creatorcontrib><creatorcontrib>Burden, Adrian</creatorcontrib><creatorcontrib>Payton, Carl</creatorcontrib><creatorcontrib>Morse, Christopher</creatorcontrib><title>Whole-body and segmental analysis of body composition in adult males with achondroplasia using dual X-ray absorptiometry</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Achondroplasia is a condition characterized by a genetic mutation affecting long bone endplate development. Current data suggests that the bone mineral content (BMC) and bone mineral density (BMD) of achondroplasic populations are below age matched individuals of average stature (controls). Due to the disproportionate limb-to-torso length compared to controls however, the lower BMC and BMD may be nullified when appropriately presented. The aim of this study was to measure whole-body and segmental body composition in adult males with achondroplasia (N = 10, 22 ±3 yrs), present data relative to whole-body and whole-limb values and compare all values to age matched controls (N = 17, 22 ±2 yrs). Dual X-ray absorptiometry (DEXA) was used to measure the in vivo mass of the whole-body and 15 segments, from which BMD, BMC, fat free mass (FFM) and body fat mass were measured. BMC of lumbar vertebrae (L1-4) was also measured and presented as a volumetric BMD (BMDVOL). The achondroplasic group had less BMC, BMD and FFM, and more body fat mass than controls as a whole-body measure. The lower achondroplasic BMC and BMD was somewhat nullified when presented relative to whole-body and whole-limb values respectively. There was no difference in lumbar BMDVOL between groups. Whole-body BMD measures presented the achondroplasic group as 'osteopenic'. When relative to whole-limb measures however, achondroplasic BMD descriptions were normal. Further work is needed to create a body composition database for achondroplasic population's, or for clinicians to present achondroplasic body composition values relative to the whole-limb.</description><subject>Absorptiometry</subject><subject>Absorptiometry, Photon - methods</subject><subject>Achondroplasia</subject><subject>Achondroplasia - diagnostic imaging</subject><subject>Achondroplasia - epidemiology</subject><subject>Achondroplasia - pathology</subject><subject>Adult</subject><subject>Adults</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Biomedical materials</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Bone Density</subject><subject>Bone mineral content</subject><subject>Bone mineral density</subject><subject>Bones</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Dwarfism</subject><subject>England - epidemiology</subject><subject>Exercise</subject><subject>Gene mutation</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Long bone</subject><subject>Male</subject><subject>Males</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic syndrome</subject><subject>Minerals - analysis</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Obesity</subject><subject>Older people</subject><subject>Osteoporosis</subject><subject>Physiology</subject><subject>Predictive Value of Tests</subject><subject>Radiography</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Torso</subject><subject>Vertebrae</subject><subject>Weight control</subject><subject>Whole Body Imaging - methods</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLguhFxyRNP3IjLIsfAwsLft-F0zRpM6RNN2l159-bmekuU9kLCTTpyfO-aU_OiaLnGK1wWuB3Gzu5HsxqsL1cIYLTEuUPolPMUpLkBKUPj9Yn0RPvNwhlaZnnj6OTFJUlwyw_jW5-ttbIpLL1Noa-jr1sOtmPYMIbmK3XPrYq3m8L2w3W61HbPtZ9DPVkxrgDI338R49tDKK1fe3sYMBriCev-yaup2D1K3EQ7Ctv3RDknRzd9mn0SIHx8tk8n0XfP374dvE5ubz6tL44v0xEzsiYVDJLi4pSQiQCVpQEZ4LhVLK6rliGBBYpAoxAMiIIZUrSTKkCZ5SiPMMYpWfRy4PvYKznc9I8J5jRnKEMkUCsD0RtYcMHpztwW25B833AuoaDG7Uwkmd1iQuoVQEKKEOqIkqEpyxwiMlaBK_382lT1YVASKUDszBd7vS65Y39zXNKKMVlMHgzGzh7PUk_8k57IY2BXtrp8N1ZSTFhAX31D3r_381UE26K617ZcK7YmfLzrGBkzwVqdQ8VRi07LUKFKR3iC8HbhSAwo7wZG5i85-uvX_6fvfqxZF8fsa0EM7bemmlXdX4J0gMonPXeSXWXZIz4rkFus8F3DcLnBgmyF8cXdCe67Yj0LxQQDUI</recordid><startdate>20190319</startdate><enddate>20190319</enddate><creator>Sims, David</creator><creator>Onambélé-Pearson, Gladys</creator><creator>Burden, Adrian</creator><creator>Payton, Carl</creator><creator>Morse, Christopher</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0152-866X</orcidid></search><sort><creationdate>20190319</creationdate><title>Whole-body and segmental analysis of body composition in adult males with achondroplasia using dual X-ray absorptiometry</title><author>Sims, David ; Onambélé-Pearson, Gladys ; Burden, Adrian ; Payton, Carl ; Morse, Christopher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-be537b4422e0a978215c913e9ddb950c1c30a10ae92c249fe45ff715440651103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Absorptiometry</topic><topic>Absorptiometry, Photon - methods</topic><topic>Achondroplasia</topic><topic>Achondroplasia - diagnostic imaging</topic><topic>Achondroplasia - epidemiology</topic><topic>Achondroplasia - pathology</topic><topic>Adult</topic><topic>Adults</topic><topic>Biocompatibility</topic><topic>Biology and Life Sciences</topic><topic>Biomedical materials</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Bone Density</topic><topic>Bone mineral content</topic><topic>Bone mineral density</topic><topic>Bones</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Dwarfism</topic><topic>England - epidemiology</topic><topic>Exercise</topic><topic>Gene mutation</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Long bone</topic><topic>Male</topic><topic>Males</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic syndrome</topic><topic>Minerals - analysis</topic><topic>Mortality</topic><topic>Mutation</topic><topic>Obesity</topic><topic>Older people</topic><topic>Osteoporosis</topic><topic>Physiology</topic><topic>Predictive Value of Tests</topic><topic>Radiography</topic><topic>Studies</topic><topic>Systematic review</topic><topic>Torso</topic><topic>Vertebrae</topic><topic>Weight control</topic><topic>Whole Body Imaging - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sims, David</creatorcontrib><creatorcontrib>Onambélé-Pearson, Gladys</creatorcontrib><creatorcontrib>Burden, Adrian</creatorcontrib><creatorcontrib>Payton, Carl</creatorcontrib><creatorcontrib>Morse, Christopher</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sims, David</au><au>Onambélé-Pearson, Gladys</au><au>Burden, Adrian</au><au>Payton, Carl</au><au>Morse, Christopher</au><au>Reddy, Sakamuri V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-body and segmental analysis of body composition in adult males with achondroplasia using dual X-ray absorptiometry</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-03-19</date><risdate>2019</risdate><volume>14</volume><issue>3</issue><spage>e0213806</spage><pages>e0213806-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Achondroplasia is a condition characterized by a genetic mutation affecting long bone endplate development. Current data suggests that the bone mineral content (BMC) and bone mineral density (BMD) of achondroplasic populations are below age matched individuals of average stature (controls). Due to the disproportionate limb-to-torso length compared to controls however, the lower BMC and BMD may be nullified when appropriately presented. The aim of this study was to measure whole-body and segmental body composition in adult males with achondroplasia (N = 10, 22 ±3 yrs), present data relative to whole-body and whole-limb values and compare all values to age matched controls (N = 17, 22 ±2 yrs). Dual X-ray absorptiometry (DEXA) was used to measure the in vivo mass of the whole-body and 15 segments, from which BMD, BMC, fat free mass (FFM) and body fat mass were measured. BMC of lumbar vertebrae (L1-4) was also measured and presented as a volumetric BMD (BMDVOL). The achondroplasic group had less BMC, BMD and FFM, and more body fat mass than controls as a whole-body measure. The lower achondroplasic BMC and BMD was somewhat nullified when presented relative to whole-body and whole-limb values respectively. There was no difference in lumbar BMDVOL between groups. Whole-body BMD measures presented the achondroplasic group as 'osteopenic'. When relative to whole-limb measures however, achondroplasic BMD descriptions were normal. Further work is needed to create a body composition database for achondroplasic population's, or for clinicians to present achondroplasic body composition values relative to the whole-limb.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30889196</pmid><doi>10.1371/journal.pone.0213806</doi><tpages>e0213806</tpages><orcidid>https://orcid.org/0000-0003-0152-866X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-03, Vol.14 (3), p.e0213806 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2194690502 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Absorptiometry Absorptiometry, Photon - methods Achondroplasia Achondroplasia - diagnostic imaging Achondroplasia - epidemiology Achondroplasia - pathology Adult Adults Biocompatibility Biology and Life Sciences Biomedical materials Body Composition Body fat Bone Density Bone mineral content Bone mineral density Bones Cardiovascular disease Care and treatment Case-Control Studies Dual energy X-ray absorptiometry Dwarfism England - epidemiology Exercise Gene mutation Genetic aspects Humans Image Processing, Computer-Assisted - methods Long bone Male Males Medicine and Health Sciences Metabolic syndrome Minerals - analysis Mortality Mutation Obesity Older people Osteoporosis Physiology Predictive Value of Tests Radiography Studies Systematic review Torso Vertebrae Weight control Whole Body Imaging - methods Young Adult |
| title | Whole-body and segmental analysis of body composition in adult males with achondroplasia using dual X-ray absorptiometry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T12%3A34%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Whole-body%20and%20segmental%20analysis%20of%20body%20composition%20in%20adult%20males%20with%20achondroplasia%20using%20dual%20X-ray%20absorptiometry&rft.jtitle=PloS%20one&rft.au=Sims,%20David&rft.date=2019-03-19&rft.volume=14&rft.issue=3&rft.spage=e0213806&rft.pages=e0213806-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0213806&rft_dat=%3Cgale_plos_%3EA579246905%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2194690502&rft_id=info:pmid/30889196&rft_galeid=A579246905&rft_doaj_id=oai_doaj_org_article_5d817adf7afa490fb2fc0fbe71df7edc&rfr_iscdi=true |