Diagnostic performance of a point shear wave elastography (pSWE) for hepatic fibrosis in patients with autoimmune liver disease
Elastography point quantification is a convenient method for measuring liver stiffness. It can be performed simultaneously with conventional ultrasonography. This study aimed to evaluate its diagnostic performance for assessing hepatic fibrosis in patients with autoimmune liver disease (AILD), inclu...
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| Veröffentlicht in: | PloS one 2019-03, Vol.14 (3), p.e0212771-e0212771 |
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| creator | Park, Dong Won Lee, Yoon Jin Chang, Won Park, Ji Hoon Lee, Kyoung Ho Kim, Young Hoon Kang, Nam Kyu Chung, Jung Wha Jang, Hee Yoon Ahn, Soomin Kim, Haeryoung Jeong, Sook-Hyang Kim, Jin-Wook Jang, Eun Sun |
| description | Elastography point quantification is a convenient method for measuring liver stiffness. It can be performed simultaneously with conventional ultrasonography. This study aimed to evaluate its diagnostic performance for assessing hepatic fibrosis in patients with autoimmune liver disease (AILD), including autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC).
The diagnostic performance of elastography point quantification (ElastPQ) was evaluated and compared with that of serum fibrosis markers, including the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 (FIB-4), using the receiver operating characteristics analysis with histologic evaluation as the reference standard.
In 49 AIH patients, sensitivity and specificity of ElastPQ were 93.6% and 44.4%, respectively, for significant fibrosis (≥ F2, cutoff 4.47 kPa), and 63.6% and 86.8% for cirrhosis (F4, cutoff 9.28 kPa). In 41 PBC patients, they were 81.8% and 73.3%, respectively, for significant fibrosis (≥ F2, cutoff 5.56 kPa), and 100% and 81.6%, respectively, for advanced fibrosis (≥ F3, cutoff 6.04 kPa). The areas under the receiver operating characteristic curves of ElastPQ for significant fibrosis (0.77, 95% CI 0.67-0.86) and cirrhosis (0.81, 95% CI 0.65-0.96) were higher than those of APRI and FIB-4 in AILD patients. According to the multivariable analysis, histological activity, steatosis, and body max index (BMI) were not significant factors that influenced the result of ElastPQ.
ElastPQ exhibited better diagnostic performance-without the influence of confounding factors-for assessing hepatic fibrosis in AILD patients than serum fibrosis markers. |
| doi_str_mv | 10.1371/journal.pone.0212771 |
| format | Article |
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The diagnostic performance of elastography point quantification (ElastPQ) was evaluated and compared with that of serum fibrosis markers, including the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 (FIB-4), using the receiver operating characteristics analysis with histologic evaluation as the reference standard.
In 49 AIH patients, sensitivity and specificity of ElastPQ were 93.6% and 44.4%, respectively, for significant fibrosis (≥ F2, cutoff 4.47 kPa), and 63.6% and 86.8% for cirrhosis (F4, cutoff 9.28 kPa). In 41 PBC patients, they were 81.8% and 73.3%, respectively, for significant fibrosis (≥ F2, cutoff 5.56 kPa), and 100% and 81.6%, respectively, for advanced fibrosis (≥ F3, cutoff 6.04 kPa). The areas under the receiver operating characteristic curves of ElastPQ for significant fibrosis (0.77, 95% CI 0.67-0.86) and cirrhosis (0.81, 95% CI 0.65-0.96) were higher than those of APRI and FIB-4 in AILD patients. According to the multivariable analysis, histological activity, steatosis, and body max index (BMI) were not significant factors that influenced the result of ElastPQ.
ElastPQ exhibited better diagnostic performance-without the influence of confounding factors-for assessing hepatic fibrosis in AILD patients than serum fibrosis markers.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0212771</identifier><identifier>PMID: 30856201</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acoustics ; Adult ; Aged ; Aspartate ; Aspartate aminotransferase ; Aspartate Aminotransferases - blood ; Biology and Life Sciences ; Biomarkers - blood ; Body mass ; Cholangitis ; Chronic active hepatitis ; Cirrhosis ; Diagnosis ; Diagnostic imaging ; Diagnostic systems ; Elasticity Imaging Techniques ; Female ; Fibrosis ; Hepatitis ; Hepatitis, Autoimmune - blood ; Hepatitis, Autoimmune - complications ; Hepatitis, Autoimmune - diagnostic imaging ; Hepatology ; Humans ; Internal medicine ; Liver ; Liver cirrhosis ; Liver Cirrhosis - blood ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - etiology ; Liver Cirrhosis, Biliary - blood ; Liver Cirrhosis, Biliary - complications ; Liver Cirrhosis, Biliary - diagnostic imaging ; Liver diseases ; Male ; Markers ; Medical diagnosis ; Medical research ; Medicine ; Medicine and Health Sciences ; Methods ; Middle Aged ; Pathology ; Patients ; Risk factors ; Sensitivity analysis ; Steatosis ; Stiffness ; Ultrasonic imaging ; Ultrasound ; Ultrasound imaging</subject><ispartof>PloS one, 2019-03, Vol.14 (3), p.e0212771-e0212771</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Park et al 2019 Park et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-99b9aff8d1ebdc87f0cb6c6a79a8f43b0087b7d1eeb9c9dee075ae8e1cc758a63</citedby><cites>FETCH-LOGICAL-c593t-99b9aff8d1ebdc87f0cb6c6a79a8f43b0087b7d1eeb9c9dee075ae8e1cc758a63</cites><orcidid>0000-0003-4274-2582 ; 0000-0003-3648-3406</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411150/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411150/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30856201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sookoian, Silvia C.</contributor><creatorcontrib>Park, Dong Won</creatorcontrib><creatorcontrib>Lee, Yoon Jin</creatorcontrib><creatorcontrib>Chang, Won</creatorcontrib><creatorcontrib>Park, Ji Hoon</creatorcontrib><creatorcontrib>Lee, Kyoung Ho</creatorcontrib><creatorcontrib>Kim, Young Hoon</creatorcontrib><creatorcontrib>Kang, Nam Kyu</creatorcontrib><creatorcontrib>Chung, Jung Wha</creatorcontrib><creatorcontrib>Jang, Hee Yoon</creatorcontrib><creatorcontrib>Ahn, Soomin</creatorcontrib><creatorcontrib>Kim, Haeryoung</creatorcontrib><creatorcontrib>Jeong, Sook-Hyang</creatorcontrib><creatorcontrib>Kim, Jin-Wook</creatorcontrib><creatorcontrib>Jang, Eun Sun</creatorcontrib><title>Diagnostic performance of a point shear wave elastography (pSWE) for hepatic fibrosis in patients with autoimmune liver disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Elastography point quantification is a convenient method for measuring liver stiffness. It can be performed simultaneously with conventional ultrasonography. This study aimed to evaluate its diagnostic performance for assessing hepatic fibrosis in patients with autoimmune liver disease (AILD), including autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC).
The diagnostic performance of elastography point quantification (ElastPQ) was evaluated and compared with that of serum fibrosis markers, including the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 (FIB-4), using the receiver operating characteristics analysis with histologic evaluation as the reference standard.
In 49 AIH patients, sensitivity and specificity of ElastPQ were 93.6% and 44.4%, respectively, for significant fibrosis (≥ F2, cutoff 4.47 kPa), and 63.6% and 86.8% for cirrhosis (F4, cutoff 9.28 kPa). In 41 PBC patients, they were 81.8% and 73.3%, respectively, for significant fibrosis (≥ F2, cutoff 5.56 kPa), and 100% and 81.6%, respectively, for advanced fibrosis (≥ F3, cutoff 6.04 kPa). The areas under the receiver operating characteristic curves of ElastPQ for significant fibrosis (0.77, 95% CI 0.67-0.86) and cirrhosis (0.81, 95% CI 0.65-0.96) were higher than those of APRI and FIB-4 in AILD patients. According to the multivariable analysis, histological activity, steatosis, and body max index (BMI) were not significant factors that influenced the result of ElastPQ.
ElastPQ exhibited better diagnostic performance-without the influence of confounding factors-for assessing hepatic fibrosis in AILD patients than serum fibrosis markers.</description><subject>Acoustics</subject><subject>Adult</subject><subject>Aged</subject><subject>Aspartate</subject><subject>Aspartate aminotransferase</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - blood</subject><subject>Body mass</subject><subject>Cholangitis</subject><subject>Chronic active hepatitis</subject><subject>Cirrhosis</subject><subject>Diagnosis</subject><subject>Diagnostic imaging</subject><subject>Diagnostic systems</subject><subject>Elasticity Imaging Techniques</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Hepatitis</subject><subject>Hepatitis, Autoimmune - blood</subject><subject>Hepatitis, Autoimmune - complications</subject><subject>Hepatitis, Autoimmune - diagnostic imaging</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver Cirrhosis, Biliary - blood</subject><subject>Liver Cirrhosis, Biliary - complications</subject><subject>Liver Cirrhosis, Biliary - diagnostic imaging</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Markers</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Sensitivity analysis</subject><subject>Steatosis</subject><subject>Stiffness</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Ultrasound imaging</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIlsI_QGCJSznsYsdJbF-QqlKgUiUOgDhaE2e861USBztp1RN_HYdNqy6qfLA1896bD78se83omnHBPuz8FHpo14PvcU1zlgvBnmTHTPF8VeWUP33wPspexLijtOSyqp5nR5zKMsXZcfbnk4NN7-PoDBkwWB866A0SbwmQwbt-JHGLEMgNXCPBFuLoNwGG7S05Hb7_unhPEoVscYBZwbo6-OgicT2ZI9iPkdy4cUtgGr3ruqlH0rprDKRxESHiy-yZhTbiq-U-yX5-vvhx_nV19e3L5fnZ1cqUio8rpWoF1sqGYd0YKSw1dWUqEAqkLXhNqRS1SFmslVENIhUloERmjCglVPwke7vXHVof9bK7qHOmqMzzgrOEuNwjGg87PQTXQbjVHpz-F_BhoyGkIVvUQtgCKiYsF3VBJSppTWWZZECrHNAkrY9LtanusDFpDwHaA9HDTO-2euOvdVUwxkqaBE4XgeB_TxhH3blosG2hRz_t-y6kVEIl6Lv_oI9Pt6A2kAZwvfWprplF9VkphFKM5fOW1o-g0mmwcyYZzboUPyAUe4JJ_x4D2vsZGdWzTe-a0bNN9WLTRHvzcD_3pDtf8r_X4ufO</recordid><startdate>20190311</startdate><enddate>20190311</enddate><creator>Park, 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performance of a point shear wave elastography (pSWE) for hepatic fibrosis in patients with autoimmune liver disease</title><author>Park, Dong Won ; Lee, Yoon Jin ; Chang, Won ; Park, Ji Hoon ; Lee, Kyoung Ho ; Kim, Young Hoon ; Kang, Nam Kyu ; Chung, Jung Wha ; Jang, Hee Yoon ; Ahn, Soomin ; Kim, Haeryoung ; Jeong, Sook-Hyang ; Kim, Jin-Wook ; Jang, Eun Sun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-99b9aff8d1ebdc87f0cb6c6a79a8f43b0087b7d1eeb9c9dee075ae8e1cc758a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acoustics</topic><topic>Adult</topic><topic>Aged</topic><topic>Aspartate</topic><topic>Aspartate aminotransferase</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - blood</topic><topic>Body mass</topic><topic>Cholangitis</topic><topic>Chronic active hepatitis</topic><topic>Cirrhosis</topic><topic>Diagnosis</topic><topic>Diagnostic imaging</topic><topic>Diagnostic systems</topic><topic>Elasticity Imaging Techniques</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Hepatitis</topic><topic>Hepatitis, Autoimmune - blood</topic><topic>Hepatitis, Autoimmune - complications</topic><topic>Hepatitis, Autoimmune - diagnostic imaging</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Cirrhosis, Biliary - blood</topic><topic>Liver Cirrhosis, Biliary - complications</topic><topic>Liver Cirrhosis, Biliary - diagnostic imaging</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Markers</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Sensitivity analysis</topic><topic>Steatosis</topic><topic>Stiffness</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><topic>Ultrasound imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Dong Won</creatorcontrib><creatorcontrib>Lee, Yoon Jin</creatorcontrib><creatorcontrib>Chang, Won</creatorcontrib><creatorcontrib>Park, Ji Hoon</creatorcontrib><creatorcontrib>Lee, Kyoung Ho</creatorcontrib><creatorcontrib>Kim, Young Hoon</creatorcontrib><creatorcontrib>Kang, Nam Kyu</creatorcontrib><creatorcontrib>Chung, Jung Wha</creatorcontrib><creatorcontrib>Jang, Hee Yoon</creatorcontrib><creatorcontrib>Ahn, Soomin</creatorcontrib><creatorcontrib>Kim, Haeryoung</creatorcontrib><creatorcontrib>Jeong, Sook-Hyang</creatorcontrib><creatorcontrib>Kim, 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Jin-Wook</au><au>Jang, Eun Sun</au><au>Sookoian, Silvia C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic performance of a point shear wave elastography (pSWE) for hepatic fibrosis in patients with autoimmune liver disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-03-11</date><risdate>2019</risdate><volume>14</volume><issue>3</issue><spage>e0212771</spage><epage>e0212771</epage><pages>e0212771-e0212771</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Elastography point quantification is a convenient method for measuring liver stiffness. It can be performed simultaneously with conventional ultrasonography. This study aimed to evaluate its diagnostic performance for assessing hepatic fibrosis in patients with autoimmune liver disease (AILD), including autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC).
The diagnostic performance of elastography point quantification (ElastPQ) was evaluated and compared with that of serum fibrosis markers, including the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 (FIB-4), using the receiver operating characteristics analysis with histologic evaluation as the reference standard.
In 49 AIH patients, sensitivity and specificity of ElastPQ were 93.6% and 44.4%, respectively, for significant fibrosis (≥ F2, cutoff 4.47 kPa), and 63.6% and 86.8% for cirrhosis (F4, cutoff 9.28 kPa). In 41 PBC patients, they were 81.8% and 73.3%, respectively, for significant fibrosis (≥ F2, cutoff 5.56 kPa), and 100% and 81.6%, respectively, for advanced fibrosis (≥ F3, cutoff 6.04 kPa). The areas under the receiver operating characteristic curves of ElastPQ for significant fibrosis (0.77, 95% CI 0.67-0.86) and cirrhosis (0.81, 95% CI 0.65-0.96) were higher than those of APRI and FIB-4 in AILD patients. According to the multivariable analysis, histological activity, steatosis, and body max index (BMI) were not significant factors that influenced the result of ElastPQ.
ElastPQ exhibited better diagnostic performance-without the influence of confounding factors-for assessing hepatic fibrosis in AILD patients than serum fibrosis markers.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30856201</pmid><doi>10.1371/journal.pone.0212771</doi><orcidid>https://orcid.org/0000-0003-4274-2582</orcidid><orcidid>https://orcid.org/0000-0003-3648-3406</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-03, Vol.14 (3), p.e0212771-e0212771 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2190822431 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acoustics Adult Aged Aspartate Aspartate aminotransferase Aspartate Aminotransferases - blood Biology and Life Sciences Biomarkers - blood Body mass Cholangitis Chronic active hepatitis Cirrhosis Diagnosis Diagnostic imaging Diagnostic systems Elasticity Imaging Techniques Female Fibrosis Hepatitis Hepatitis, Autoimmune - blood Hepatitis, Autoimmune - complications Hepatitis, Autoimmune - diagnostic imaging Hepatology Humans Internal medicine Liver Liver cirrhosis Liver Cirrhosis - blood Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - etiology Liver Cirrhosis, Biliary - blood Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - diagnostic imaging Liver diseases Male Markers Medical diagnosis Medical research Medicine Medicine and Health Sciences Methods Middle Aged Pathology Patients Risk factors Sensitivity analysis Steatosis Stiffness Ultrasonic imaging Ultrasound Ultrasound imaging |
| title | Diagnostic performance of a point shear wave elastography (pSWE) for hepatic fibrosis in patients with autoimmune liver disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T07%3A54%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnostic%20performance%20of%20a%20point%20shear%20wave%20elastography%20(pSWE)%20for%20hepatic%20fibrosis%20in%20patients%20with%20autoimmune%20liver%20disease&rft.jtitle=PloS%20one&rft.au=Park,%20Dong%20Won&rft.date=2019-03-11&rft.volume=14&rft.issue=3&rft.spage=e0212771&rft.epage=e0212771&rft.pages=e0212771-e0212771&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0212771&rft_dat=%3Cgale_plos_%3EA577991126%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2190822431&rft_id=info:pmid/30856201&rft_galeid=A577991126&rft_doaj_id=oai_doaj_org_article_77f4a617f37b408e98fc6f181a062aec&rfr_iscdi=true |