Clinical significance of soluble programmed cell death-1 and soluble programmed cell death-ligand 1 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

Inhibition of the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) axis in combination with radiotherapy may be a promising approach to treat cancer. In the present study, we aimed to evaluate serum soluble PD-1/PD-L1 levels in patients with advanced rectal cancer treated with neo...

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Veröffentlicht in:	PloS one 2019-02, Vol.14 (2), p.e0212978
Hauptverfasser:	Tominaga, Tetsuro, Akiyoshi, Takashi, Yamamoto, Noriko, Taguchi, Senzo, Mori, Seiichi, Nagasaki, Toshiya, Fukunaga, Yosuke, Ueno, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant chemotherapy Adult Aged Antigens Apoptosis Apoptosis - physiology B7-H1 Antigen - blood Biochemistry Biology and Life Sciences Cancer Cancer therapies Cancer treatment Care and treatment Cell death Chemoradiotherapy Chemoradiotherapy - methods Chemotherapy Clinical significance Clinical trials Colorectal cancer Correlation Disease-Free Survival Enzyme-Linked Immunosorbent Assay Enzymes Female Genetic aspects Hospitals Humans Immune system Immunohistochemistry Kidney Neoplasms - blood Kidney Neoplasms - drug therapy Kidney Neoplasms - therapy Leukemia Ligands Lung cancer Lymphocytes Lymphoma Male Medical prognosis Medical research Medicine and Health Sciences Middle Aged Mortality Multivariate analysis Neoadjuvant Therapy - methods Patients PD-1 protein PD-L1 protein Physical Sciences Physiological aspects Prognosis Prospective Studies Radiation therapy Radiotherapy Rectum Research and Analysis Methods Surgery Therapeutic applications Tumors
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